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    Frmd5 FERM domain containing [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34398, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Frmd5provided by FlyBase
    Official Full Name
    FERM domain containingprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032225
    Locus tag
    Dmel_CG5022
    See related
    AllianceGenome:FB:FBgn0032225
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5022; dFrmd; Dmel\CG5022
    Summary
    Predicted to enable cytoskeletal protein binding activity. Predicted to be involved in actomyosin structure organization. Predicted to be active in cytoskeleton. Is expressed in several structures, including adult antennal lobe; adult head; adult mushroom body; adult optic lobe; and larval ventral nerve cord. Used to study neurodevelopmental disorder with eye movement abnormalities and ataxia. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with eye movement abnormalities and ataxia. Orthologous to several human genes including FRMD5 (FERM domain containing 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Frmd5 in Genome Data Viewer
    Location:
    31D9-31D9; 2-41 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10344442..10347706)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10344442..10347706)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Selenophosphate synthetase 2 Neighboring gene uncharacterized protein Neighboring gene Cathepsin L4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. De novo variants in FRMD5 are associated with developmental delay, intellectual disability, ataxia, and abnormalities of eye movement. Lu S, et al. Am J Hum Genet, 2022 Oct 6. PMID 36206744, Free PMC Article
    2. The class 2 selenophosphate synthetase gene of Drosophila contains a functional mammalian-type SECIS. Hirosawa-Takamori M, et al. EMBO Rep, 2000 Nov. PMID 11258485, Free PMC Article
    3. Drosophila Yurt is a new protein-4.1-like protein required for epithelial morphogenesis. Hoover KB, et al. Dev Genes Evol, 2002 Jun. PMID 12070613
    4. A genome-wide screen identifies conserved protein hubs required for cadherin-mediated cell-cell adhesion. Toret CP, et al. J Cell Biol, 2014 Jan 20. PMID 24446484, Free PMC Article
    5. Comparative transcriptomics between Drosophila mojavensis and D. arizonae reveals transgressive gene expression and underexpression of spermatogenesis-related genes in hybrid testes. Banho CA, et al. Sci Rep, 2021 May 10. PMID 33972659, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cytoskeletal protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in actomyosin structure organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    FERM domain containing
    Names
    CG5022-PA
    Frmd5-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      10344442..10347706
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135540.2 → NP_609384.1  FERM domain containing [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609384.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86P10, Q9VKY7
      Related
      FBpp0079589
      Conserved Domains (5) summary
      smart00295
      Location:13 → 205
      B41; Band 4.1 homologues
      cd13192
      Location:186 → 294
      FERM_C_FRMD3_FRMD5; FERM domain C-lobe of FERM domain-containing protein 3 and 5 (FRMD3 and 5)
      pfam00373
      Location:108 → 205
      FERM_M; FERM central domain
      pfam08736
      Location:308 → 349
      FA; FERM adjacent (FA)
      pfam09379
      Location:16 → 80
      FERM_N; FERM N-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86P10 Q86P10
    Q9VKY7 Q9VKY7

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