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    pain painless [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37985, updated on 17-Dec-2024

    Summary

    Official Symbol
    painprovided by FlyBase
    Official Full Name
    painlessprovided by FlyBase
    Primary source
    FLYBASE:FBgn0060296
    Locus tag
    Dmel_CG15860
    See related
    AllianceGenome:FB:FBgn0060296
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG15860; CT31987; Dmel\CG15860; EP2251; Pain; Painless; TRPA
    Summary
    Enables calcium channel activity and calcium-activated cation channel activity. Involved in several processes, including detection of stimulus involved in sensory perception; mechanosensory behavior; and negative gravitaxis. Located in plasma membrane. Part of calcium channel complex. Is expressed in several structures, including brain; central nervous system; embryonic/larval lateral glial cell; ganglia; and organism subdivision. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See pain in Genome Data Viewer
    Location:
    60E5-60E5; 2-107 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24921505..24928275, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (20809028..20815798, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Na channel protein 60E Neighboring gene uncharacterized protein Neighboring gene Thiamine pyrophosphate carrier protein 2 Neighboring gene Ribosomal protein L41 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by FlyBase

    Items 1 - 25 of 26
    Process Evidence Code Pubs
    involved_in behavioral response to pain PubMed 
    involved_in calcium ion transmembrane transport PubMed 
    involved_in calcium ion transport PubMed 
    involved_in copulation PubMed 
    involved_in detection of hot stimulus involved in thermoception PubMed 
    involved_in detection of mechanical stimulus involved in sensory perception PubMed 
    involved_in detection of mechanical stimulus involved in sensory perception of pain PubMed 
    involved_in detection of temperature stimulus involved in sensory perception of pain PubMed 
    involved_in detection of temperature stimulus involved in thermoception PubMed 
    involved_in detection of temperature stimulus involved in thermoception PubMed 
    involved_in feeding behavior PubMed 
    involved_in larval locomotory behavior PubMed 
    involved_in male courtship behavior PubMed 
    involved_in mechanosensory behavior PubMed 
    involved_in monoatomic ion transmembrane transport  
    involved_in monoatomic ion transport  
    involved_in negative gravitaxis PubMed 
    involved_in olfactory behavior PubMed 
    involved_in regulation of female receptivity PubMed 
    involved_in regulation of heart contraction PubMed 
    involved_in response to heat PubMed 
    involved_in response to heat PubMed 
    involved_in response to mechanical stimulus PubMed 
    involved_in sensory perception of pain PubMed 
    NOT involved_in thermotaxis PubMed 
    involved_in transmembrane transport  
    Items 1 - 25 of 26
    Component Evidence Code Pubs
    part_of calcium channel complex PubMed 
    located_in membrane  
    located_in membrane PubMed 
    located_in plasma membrane PubMed 
    part_of transmembrane transporter complex  

    General protein information

    Preferred Names
    painless
    Names
    CG15860-PA
    CG15860-PB
    CG15860-PC
    pain-PA
    pain-PB
    pain-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      24921505..24928275 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274247.2 → NP_001261176.1  painless, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261176.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KEZ8
      Conserved Domains (4) summary
      cd00204
      Location:19 → 122
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam00520
      Location:241 → 462
      Ion_trans; Ion transport protein
      pfam12796
      Location:19 → 114
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:40 → 82
      ANK; ANK repeat [structural motif]
    2. NM_138135.2 → NP_611979.1  painless, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611979.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9W0Y6
      Related
      FBpp0072323
      Conserved Domains (4) summary
      cd00204
      Location:56 → 180
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam00520
      Location:525 → 746
      Ion_trans; Ion transport protein
      pfam12796
      Location:303 → 398
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:82 → 111
      ANK; ANK repeat [structural motif]
    3. NM_001274248.1 → NP_001261177.1  painless, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261177.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KFI2
      Conserved Domains (1) summary
      pfam00520
      Location:141 → 362
      Ion_trans; Ion transport protein
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