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    CG10163 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38728, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG10163provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035697
    Locus tag
    Dmel_CG10163
    See related
    AllianceGenome:FB:FBgn0035697
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG10163
    Summary
    Predicted to enable triacylglycerol lipase activity. Predicted to be involved in lipid catabolic process. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including cardiovascular system disease (multiple); familial hyperlipidemia (multiple); hypotrichosis 7; obesity; and type 2 diabetes mellitus. Orthologous to several human genes including LIPC (lipase C, hepatic type); LIPG (lipase G, endothelial type); and LIPH (lipase H). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG10163 in Genome Data Viewer
    Location:
    65A10-65A11; 3-16 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (6257423..6258760, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (6250523..6251860, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Multi drug resistance 65 Neighboring gene Bestrophin 2 Neighboring gene Lactate dehydrogenase Neighboring gene long non-coding RNA:CR44522

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of genetic and molecular tools for studying the endogenous expression of Lactate dehydrogenase in Drosophila melanogaster. Rai M, et al. PLoS One, 2024. PMID 38170735, Free PMC Article
    2. Chromatin topology is coupled to Polycomb group protein subnuclear organization. Wani AH, et al. Nat Commun, 2016 Jan 13. PMID 26759081, Free PMC Article
    3. Comparative and functional genomics of lipases in holometabolous insects. Horne I, et al. Insect Biochem Mol Biol, 2009 Aug. PMID 19540341
    4. Genetic changes accompanying the evolution of host specialization in Drosophila sechellia. Dworkin I, et al. Genetics, 2009 Feb. PMID 19033155, Free PMC Article
    5. A targeted gain-of-function screen identifies genes affecting salivary gland morphogenesis/tubulogenesis in Drosophila. Maybeck V, et al. Genetics, 2009 Feb. PMID 19064711, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables lipase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lipase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables triacylglycerol lipase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG10163-PA
    NP_648042.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      6257423..6258760 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139785.2 → NP_648042.1  uncharacterized protein Dmel_CG10163 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648042.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C4XVI9, Q9VRW5
      Related
      FBpp0076717
      Conserved Domains (1) summary
      cl21494
      Location:91 → 349
      Abhydrolase; alpha/beta hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VRW5 Q9VRW5

    Gene LinkOut

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