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    skl sickle [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40016, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sklprovided by FlyBase
    Official Full Name
    sickleprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036786
    Locus tag
    Dmel_CG13701
    See related
    AllianceGenome:FB:FBgn0036786
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:RE14076; CG13701; Dmel\CG13701; meph; Skl; veto
    Summary
    Involved in apoptotic process; cellular response to ionizing radiation; and programmed cell death involved in cell development. Is expressed in several structures, including CNS glial cell; antennal primordium; anterior-posterior subdivision of organism; ganglia; and head epidermis primordium. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See skl in Genome Data Viewer
    Location:
    75C6-75C6; 3-45 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (18438561..18439942, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (18431661..18433042, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene reaper Neighboring gene long non-coding RNA:CR46215 Neighboring gene long non-coding RNA:CR43280 Neighboring gene long non-coding RNA:CR44670

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. New insights for Drosophila GAGA factor in larvae. Blanch M, et al. R Soc Open Sci, 2015 Mar. PMID 26064623, Free PMC Article
    2. The 'unique key' feature of the Iap-binding motifs in RHG proteins. Zhou L. Cell Death Differ, 2005 Aug. PMID 15905883, Free PMC Article
    3. Deep Conservation of Hid-Like RHG Gene Family Homologs in Winged Insects Revealed by "Taxon Hopping" BLAST. Friedrich M. Insects, 2021 Oct 21. PMID 34821758, Free PMC Article
    4. The damage-responsive Drosophila gene sickle encodes a novel IAP binding protein similar to but distinct from reaper, grim, and hid. Christich A, et al. Curr Biol, 2002 Jan 22. PMID 11818065
    5. Strong eukaryotic IRESs have weak secondary structure. Xia X, et al. PLoS One, 2009. PMID 19125192, Free PMC Article

    See all (123) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Study provide evidence that miR-6/11 functions through regulation of the proapoptotic genes, reaper (rpr), head involution defective (hid), grim and sickle (skl).
      Title: Overlapping functions of microRNAs in control of apoptosis during Drosophila embryogenesis.
    2. findings demonstrate that neuroblast apoptosis during embryogenesis requires the coordinated expression of the cell death genes grim and reaper, and possibly sickle
      Title: Coordinated expression of cell death genes regulates neuroblast apoptosis.
    3. germ line is maintained through the regulated expression of RHG genes
      Title: Maternal Nanos represses hid/skl-dependent apoptosis to maintain the germ line in Drosophila embryos.
    4. These results show that internal ribosome entry sites-dependent initiation may play a role in the translation of Drosophila proapoptotic genes and suggest a variety of regulatory pathways.
      Title: Different modes of translation for hid, grim and sickle mRNAs in Drosophila.
    5. encodes a novel IAP binding protein similar to reaper, grim and hid
      Title: The damage-responsive Drosophila gene sickle encodes a novel IAP binding protein similar to but distinct from reaper, grim, and hid.
    6. grim-reaper cell death activator
      Title: Drosophila sickle is a novel grim-reaper cell death activator.
    7. located in reaper/hid/grim region and encodes an IAP-inhibitory protein
      Title: sickle, a novel Drosophila death gene in the reaper/hid/grim region, encodes an IAP-inhibitory protein.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in apoptotic process NAS
    Non-traceable Author Statement
    more info
    		  
    involved_in cellular response to ionizing radiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in programmed cell death involved in cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    sickle
    Names
    CG13701-PA
    mephisto
    skl-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      18438561..18439942 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079415.3 → NP_524139.1  sickle [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524139.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SZ80, Q9VVP8
      Related
      FBpp0074885
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SZ80 Q8SZ80
    Q9VVP8 Q9VVP8

    Gene LinkOut

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