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    plx pollux [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40704, updated on 9-Dec-2024

    Summary

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    Official Symbol
    plxprovided by FlyBase
    Official Full Name
    polluxprovided by FlyBase
    Primary source
    FLYBASE:FBgn0261261
    Locus tag
    Dmel_CG42612
    See related
    AllianceGenome:FB:FBgn0261261
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1093; CG14674; CG34122; CG42612; Dmel\CG42612; Plx
    Old locus tag
    Dmel_CG1093; Dmel_CG14674; Dmel_CG34122
    Summary
    Enables integrin binding activity and small GTPase binding activity. Involved in cell adhesion mediated by integrin. Located in Golgi apparatus and cell surface. Is expressed in several structures, including cell body; female germline cell; larval longitudinal connective; presumptive embryonic/larval central nervous system; and pupal endocuticle. Human ortholog(s) of this gene implicated in acanthosis nigricans. Orthologous to human TBC1D1 (TBC1 domain family member 1) and TBC1D4 (TBC1 domain family member 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See plx in Genome Data Viewer
    Location:
    83B9-83C1; 3-47.5 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (5685855..5712837)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (1511577..1538559)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Autophagy-related 17 Neighboring gene Rab23 Neighboring gene uncharacterized protein Neighboring gene castor Neighboring gene long non-coding RNA:CR44924

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A shared domain between a spindle assembly checkpoint protein and Ypt/Rab-specific GTPase-activators. Neuwald AF. Trends Biochem Sci, 1997 Jul. PMID 9255064
    2. castor encodes a novel zinc finger protein required for the development of a subset of CNS neurons in Drosophila. Mellerick DM, et al. Neuron, 1992 Nov. PMID 1418995
    3. Pollux, a novel Drosophila adhesion molecule, belongs to a family of proteins expressed in plants, yeast, nematodes, and man. Zhang SD, et al. Genes Dev, 1996 May 1. PMID 8654926
    4. Sequence and expression analysis of a Drosophila gene product related to the tre oncogene. Yedvobnick B, et al. Biochim Biophys Acta, 1998 Feb 11. PMID 9512660
    5. Comparative validation of the D. melanogaster modENCODE transcriptome annotation. Chen ZX, et al. Genome Res, 2014 Jul. PMID 24985915, Free PMC Article

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables integrin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell adhesion mediated by integrin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    pollux
    Names
    CG42612-PA
    CG42612-PC
    CG42612-PD
    CG42612-PE
    CG42612-PF
    plx-PA
    plx-PC
    plx-PD
    plx-PE
    plx-PF

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      5685855..5712837
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275368.1 → NP_001262297.1  pollux, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262297.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KGK7, Q9TY11
      Conserved Domains (4) summary
      smart00164
      Location:879 → 1098
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      cd01269
      Location:301 → 547
      PTB_TBC1D1_like; TBC1 domain family member 1 and related proteins Phosphotyrosine-binding (PTB) domain
      pfam11830
      Location:781 → 826
      DUF3350; Domain of unknown function (DUF3350)
      cl23720
      Location:1122 → 1213
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    2. NM_001170040.2 → NP_001163511.1  pollux, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163511.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JJ52, Q9TY11
      Conserved Domains (4) summary
      smart00164
      Location:933 → 1152
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      cd01269
      Location:301 → 601
      PTB_TBC1D1_like; TBC1 domain family member 1 and related proteins Phosphotyrosine-binding (PTB) domain
      pfam11830
      Location:835 → 880
      DUF3350; Domain of unknown function (DUF3350)
      cl23720
      Location:1176 → 1267
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    3. NM_169095.3 → NP_730989.2  pollux, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730989.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IPP5, Q9TY11
      Conserved Domains (4) summary
      smart00164
      Location:767 → 986
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      cd01269
      Location:135 → 435
      PTB_TBC1D1_like; TBC1 domain family member 1 and related proteins Phosphotyrosine-binding (PTB) domain
      pfam11830
      Location:669 → 714
      DUF3350; Domain of unknown function (DUF3350)
      cl23720
      Location:1010 → 1101
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    4. NM_001275369.1 → NP_001262298.1  pollux, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262298.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KG76, Q9TY11
      Conserved Domains (4) summary
      smart00164
      Location:713 → 932
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      cd01269
      Location:135 → 381
      PTB_TBC1D1_like; TBC1 domain family member 1 and related proteins Phosphotyrosine-binding (PTB) domain
      pfam11830
      Location:615 → 660
      DUF3350; Domain of unknown function (DUF3350)
      cl23720
      Location:956 → 1047
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    5. NM_169094.2 → NP_730988.1  pollux, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730988.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9TY11, Q9VNG9
      Related
      FBpp0291300
      Conserved Domains (4) summary
      smart00164
      Location:740 → 959
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      cd01269
      Location:108 → 408
      PTB_TBC1D1_like; TBC1 domain family member 1 and related proteins Phosphotyrosine-binding (PTB) domain
      pfam11830
      Location:642 → 687
      DUF3350; Domain of unknown function (DUF3350)
      cl23720
      Location:983 → 1074
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KG76 A0A0B4KG76
    A0A0B4KGK7 A0A0B4KGK7
    E1JJ52 E1JJ52
    Q24193 Q24193
    Q6AWQ6 Q6AWQ6
    Q8IPP5 Q8IPP5
    Q9TY11 Q9TY11
    Q9VNG9 Q9VNG9

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