atl atlastin [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: atlprovided by FlyBase
Official Full Name: atlastinprovided by FlyBase
Primary source: FLYBASE:FBgn0039213
Locus tag: Dmel_CG6668
See related: AllianceGenome:FB:FBgn0039213
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: Atl; ATL; Atlastin-1; CG6668; dAtl; DATL; Dmel\CG6668
Summary: Enables several functions, including GTP binding activity; GTP-dependent protein binding activity; and endoplasmic reticulum-autophagosome adaptor activity. Involved in several processes, including endoplasmic reticulum membrane fusion; positive regulation of axon extension involved in regeneration; and reticulophagy. Located in Golgi apparatus and endoplasmic reticulum membrane. Colocalizes with microtubule. Is expressed in several structures, including adult head; brain; embryonic/larval midgut primordium; female germline cell; and gut section. Used to study hereditary spastic paraplegia and hereditary spastic paraplegia 3A. Human ortholog(s) of this gene implicated in hereditary sensory neuropathy type 1D; hereditary sensory neuropathy type 1F; and hereditary spastic paraplegia 3A. Orthologous to several human genes including ATL1 (atlastin GTPase 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 96A13-96A13; 3-85 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (24625671..24634714)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (20451393..20460436)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Atl (atlastin) regulates mTor signaling and autophagy in Drosophila muscle through alteration of the lysosomal network.
Title: Atl (atlastin) regulates mTor signaling and autophagy in Drosophila muscle through alteration of the lysosomal network.
Drosophila Atlastin regulates synaptic vesicle mobilization independent of bone morphogenetic protein signaling.
Title: Drosophila Atlastin regulates synaptic vesicle mobilization independent of bone morphogenetic protein signaling.
found that both human and Drosophila atlastin hydrophobic membrane anchors do not span the membrane, but rather form two intramembrane hairpin loops. The topology of these hairpins remains static during membrane fusion and does not appear to play an active role in lipid mixing
Title: The atlastin membrane anchor forms an intramembrane hairpin that does not span the phospholipid bilayer.
Trafficking defects produced by Atlastin dysfunction in motor neurons result in redistribution of presynaptic components and aberrant mobilization of synaptic vesicles.
Title: Drosophila Atlastin in motor neurons is required for locomotion and presynaptic function.
this paper shows that atl is required in motor neurons to affect transmitter release
Title: The effects of ER morphology on synaptic structure and function in Drosophila melanogaster.
purified and reconstituted human ATL1 exhibited no in vitro fusion activity. When the cytosolic segment of human ATL1 was connected to the transmembrane (TM) region and C-terminal tail (CT) of Drosophila ATL
Title: Comparison of human and Drosophila atlastin GTPases.
Data indicate that expression of either the K320E or E328R atlastin GTPase (D-ATL) variant led to dominant-negative perturbations of the endoplasmic reticulum.
Title: Membrane tethering by the atlastin GTPase depends on GTP hydrolysis but not on forming the cross-over configuration.
Data indicate that GTP hydrolysis is required for atlastin (ATL)-mediated vesicle tethering.
Title: Cis and trans interactions between atlastin molecules during membrane fusion.
These data suggest that the C-terminal tail of Atlastin locally destabilizes bilayers to facilitate membrane fusion.
Title: The Atlastin C-terminal tail is an amphipathic helix that perturbs the bilayer structure during endoplasmic reticulum homotypic fusion.
VCP was validated as an atlastin-interacting protein.
Title: Characterization of the Drosophila atlastin interactome reveals VCP as a functionally related interactor.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm2238 (e-PCR)
- UniSTS:13248

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTP binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables GTP-dependent protein binding	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables endoplasmic reticulum-autophagosome adaptor activity	IDA Inferred from Direct Assay more info	PubMed
enables guanyl ribonucleotide binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Golgi organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endoplasmic reticulum membrane fusion	IDA Inferred from Direct Assay more info	PubMed
involved_in endoplasmic reticulum membrane fusion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in endoplasmic reticulum membrane fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endoplasmic reticulum organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in endoplasmic reticulum organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in membrane fusion	IDA Inferred from Direct Assay more info	PubMed
involved_in microtubule depolymerization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in muscle organ development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuromuscular junction development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of axon extension involved in regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein homooligomerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein homooligomerization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of microtubule depolymerization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synaptic assembly at neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in reticulophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic assembly at neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in endomembrane system	HDA more info	PubMed
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
is_active_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with microtubule	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: atlastin

Names: CG6668-PA; CG6668-PB; CG6668-PC; D-atlastin; atl-PA; atl-PB; atl-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

24625671..24634714

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_143017.3 → NP_651274.1 atlastin, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_651274.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9VC57

UniProtKB/TrEMBL

A0A0B4LHV8

Related

FBpp0084036

Conserved Domains (1) summary

pfam02263
Location:14 → 289

GBP; Guanylate-binding protein, N-terminal domain
NM_170157.2 → NP_733020.1 atlastin, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_733020.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9VC57

UniProtKB/TrEMBL

A0A0B4LHV8

Related

FBpp0084037

Conserved Domains (1) summary

pfam02263
Location:14 → 289

GBP; Guanylate-binding protein, N-terminal domain
NM_001300577.1 → NP_001287506.1 atlastin, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001287506.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9VC57

UniProtKB/TrEMBL

A0A0B4LHV8

Conserved Domains (1) summary

pfam02263
Location:14 → 289

GBP; Guanylate-binding protein, N-terminal domain