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    Ent2 Equilibrative nucleoside transporter 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33921, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ent2provided by FlyBase
    Official Full Name
    Equilibrative nucleoside transporter 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0263916
    Locus tag
    Dmel_CG31911
    See related
    AllianceGenome:FB:FBgn0263916
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BEST:LD04971; CG11045; CG31911; Dmel\CG31911; DmEnt2; DmENT2; ent2; ENT2; LD04971; P124
    Summary
    Enables nucleoside transmembrane transporter activity. Involved in several processes, including associative learning; negative regulation of calcium ion import; and nucleoside transmembrane transport. Located in plasma membrane. Is expressed in several structures, including adult antennal lobe; adult head; adult optic lobe; adult pars intercerebralis; and synaptic neuropil subdomain. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Ent2 in Genome Data Viewer
    Location:
    26E3-26E3; 2-21 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6562325..6564709)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6562325..6564709)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Cytochrome c oxidase subunit 5B Neighboring gene Cytochrome c oxidase subunit 5B-like Neighboring gene tRNA methyltransferase 6 non-catalytic subunit Neighboring gene uncharacterized protein Neighboring gene Dipeptidyl peptidase 10 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. [Novel memory mutants in Drosophila: behavioral characteristics of the P-insertional mutant in the Ent2P locus]. Molotova-Besedina NG, et al. Genetika, 2009 Jan. PMID 19239097
    2. Extracellular adenosine mediates a systemic metabolic switch during immune response. Bajgar A, et al. PLoS Biol, 2015 Apr. PMID 25915062, Free PMC Article
    3. Metabolic and neurobehavioral disturbances induced by purine recycling deficiency in Drosophila. Petitgas C, et al. Elife, 2024 May 3. PMID 38700995, Free PMC Article
    4. Mutation in the Drosophila melanogaster adenosine receptor gene selectively decreases the mosaic hyperplastic epithelial outgrowth rates in wts or dco heterozygous flies. Sidorov R, et al. Purinergic Signal, 2015 Mar. PMID 25528157, Free PMC Article
    5. Genomic analysis of nucleoside transporters in Diptera and functional characterization of DmENT2, a Drosophila equilibrative nucleoside transporter. Machado J, et al. Physiol Genomics, 2007 Feb 12. PMID 17090699

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results provide first evidence of a role for equilibrative nucleoside transporter 2 function in Drosophila associative learning.
      Title: Equilibrative nucleoside transporter 2 regulates associative learning and synaptic function in Drosophila.
    2. The genetic variability in Ent2 locus should be considered as a factor of risk for development of mental retardation and disorders of visual perception.
      Title: [Novel memory mutants in Drosophila: behavioral characteristics of the P-insertional mutant in the Ent2P locus].
    3. ENT2 has broad substrate specificity, is insensitive to standard nucleoside transport inhibitors and is expressed in the digestive tract of late stage embryos.
      Title: Genomic analysis of nucleoside transporters in Diptera and functional characterization of DmENT2, a Drosophila equilibrative nucleoside transporter.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables nucleoside transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleoside transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nucleoside transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleoside transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in associative learning IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of calcium ion import IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleoside transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nucleoside transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleoside transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IC
    Inferred by Curator
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    equilibrative nucleoside transporter 2
    Names
    CG31911-PA
    CG31911-PB
    Ent2-PA
    Ent2-PB
    P124
    equilibrative nucleoside transporter

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      6562325..6564709
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298751.1 → NP_001285680.1  equilibrative nucleoside transporter 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285680.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VMB6
      Conserved Domains (1) summary
      cl15430
      Location:62 → 457
      Nucleoside_tran; Nucleoside transporter

    2. NM_135205.4 → NP_609049.1  equilibrative nucleoside transporter 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609049.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VMB6
      Related
      FBpp0078920
      Conserved Domains (1) summary
      cl15430
      Location:62 → 457
      Nucleoside_tran; Nucleoside transporter
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VMB6 Q9VMB6

    Gene LinkOut

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