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    Alg7 Alg7 dolichyl-phosphate N-acetylglucosaminephosphotransferase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34711, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Alg7provided by FlyBase
    Official Full Name
    Alg7 dolichyl-phosphate N-acetylglucosaminephosphotransferaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032477
    Locus tag
    Dmel_CG5287
    See related
    AllianceGenome:FB:FBgn0032477
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5287; dAlg7; Dmel\CG5287; DPAGT1
    Summary
    Predicted to enable UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity. Predicted to be involved in dolichol-linked oligosaccharide biosynthetic process. Predicted to be part of UDP-N-acetylglucosamine transferase complex. Predicted to be active in membrane. Is expressed in adult head and embryonic proventriculus. Used to study congenital disorder of glycosylation Ij. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Ij and congenital myasthenic syndrome 13. Orthologous to human DPAGT1 (dolichyl-phosphate N-acetylglucosaminephosphotransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Alg7 in Genome Data Viewer
    Location:
    34A8-34A8; 2-47 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (13179247..13183495)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (13179247..13183495)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Scm-related gene containing four mbt domains Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase Neighboring gene uncharacterized protein Neighboring gene Radial spoke head protein 1 Neighboring gene ER degradation enhancer, mannosidase alpha-like 2 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A genetic screen in Drosophila reveals novel cytoprotective functions of the autophagy-lysosome pathway. Arsham AM, et al. PLoS One, 2009 Jun 29. PMID 19562034, Free PMC Article
    2. Isolation of gene sets affected specifically by polyglutamine expression: implication of the TOR signaling pathway in neurodegeneration. Nelson B, et al. Cell Death Differ, 2005 Aug. PMID 15861189
    3. A genome-wide CRISPR screen identifies DPM1 as a modifier of DPAGT1 deficiency and ER stress. Dalton HM, et al. PLoS Genet, 2022 Sep. PMID 36166480, Free PMC Article
    4. The BDGP gene disruption project: single transposon insertions associated with 40% of Drosophila genes. Bellen HJ, et al. Genetics, 2004 Jun. PMID 15238527, Free PMC Article
    5. Phenotype-based clustering of glycosylation-related genes by RNAi-mediated gene silencing. Yamamoto-Hino M, et al. Genes Cells, 2015 Jun. PMID 25940448, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in dolichol-linked oligosaccharide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein N-linked glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of UDP-N-acetylglucosamine transferase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Alg7 dolichyl-phosphate N-acetylglucosaminephosphotransferase
    Names
    Alg7-PA
    CG5287-PA
    NP_609608.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      13179247..13183495
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135764.4 → NP_609608.1  Alg7 dolichyl-phosphate N-acetylglucosaminephosphotransferase [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609608.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q961K7, Q9VK30
      Related
      FBpp0080017
      Conserved Domains (1) summary
      cd06855
      Location:24 → 320
      GT_GPT_euk; UDP-GlcNAc:dolichol-P GlcNAc-1-P transferase (GPT) catalyzes the transfer of GlcNAc-1-P from UDP-GlcNAc to dolichol-P to form GlcNAc-P-P-dolichol. The reaction is the first step in the assembly of dolichol-linked oligosaccharide intermediates and is ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VK30 Q9VK30

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