Coq6 Coenzyme Q6 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Coq6provided by FlyBase
Official Full Name: Coenzyme Q6provided by FlyBase
Primary source: FLYBASE:FBgn0031713
Locus tag: Dmel_CG7277
See related: AllianceGenome:FB:FBgn0031713
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG7277; Dmel\CG7277
Summary: Predicted to enable 4-hydroxy-3-all-trans-hexaprenylbenzoate oxygenase activity. Predicted to be involved in ubiquinone biosynthetic process. Predicted to be located in mitochondrial inner membrane. Predicted to be part of ubiquinone biosynthesis complex. Predicted to be active in mitochondrion. Is expressed in several structures, including adult head; adult heart; dorsal pharyngeal muscle cell; gut section; and larval muscle system. Used to study nephrotic syndrome and primary coenzyme Q10 deficiency 6. Human ortholog(s) of this gene implicated in primary coenzyme Q10 deficiency 6. Orthologous to human COQ6 (coenzyme Q6, monooxygenase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 25E5-25E5; 2-17 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (5530620..5532223, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (5530620..5532223, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables 4-hydroxy-3-all-trans-hexaprenylbenzoate oxygenase activity	IEA Inferred from Electronic Annotation more info
enables 4-hydroxy-3-all-trans-hexaprenylbenzoate oxygenase activity	ISS Inferred from Sequence or Structural Similarity more info
enables FAD binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in ubiquinone biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ubiquinone biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in ubiquinone biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
part_of ubiquinone biosynthesis complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

Go to the top of the page Help

Preferred Names: coenzyme Q6

Names: CG7277-PA; Coq6-PA

NP_608934.1

EC 1.-.-.-

EC 1.14.-.-

EC 1.14.13.-

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

5530620..5532223 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_135090.4 → NP_608934.1 coenzyme Q6 [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_608934.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9VMQ5

Related

FBpp0078759

Conserved Domains (2) summary

TIGR01988
Location:58 → 476

Ubi-OHases; Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family

TIGR01989
Location:58 → 471

COQ6; ubiquinone biosynthesis monooxygenase COQ6