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    sut2 sugar transporter 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44269, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sut2provided by FlyBase
    Official Full Name
    sugar transporter 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0028562
    Locus tag
    Dmel_CG17975
    See related
    AllianceGenome:FB:FBgn0028562
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG17975; Dmel\CG17975
    Summary
    Predicted to enable hexose transmembrane transporter activity. Predicted to be involved in monosaccharide transmembrane transport. Predicted to be active in membrane. Human ortholog(s) of this gene implicated in epilepsy (multiple); glucose transporter type 1 deficiency syndrome (multiple); myelomeningocele; obesity; and type 2 diabetes mellitus. Orthologous to several human genes including SLC2A1 (solute carrier family 2 member 1); SLC2A4 (solute carrier family 2 member 4); and SLC2A5 (solute carrier family 2 member 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See sut2 in Genome Data Viewer
    Location:
    44A4-44A4; 2-58 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8087396..8089297)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3974901..3976802)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Vacuolar protein sorting 28 Neighboring gene saliva Neighboring gene sugar transporter 1 Neighboring gene sugar transporter 3 Neighboring gene sandman Neighboring gene univalents only

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A gut-derived hormone suppresses sugar appetite and regulates food choice in Drosophila. Malita A, et al. Nat Metab, 2022 Nov. PMID 36344765, Free PMC Article
    2. A glucose-sensing neuron pair regulates insulin and glucagon in Drosophila. Oh Y, et al. Nature, 2019 Oct. PMID 31645735, Free PMC Article
    3. Regulation of Notch signaling in the developing Drosophila eye by a T-box containing transcription factor, Dorsocross. Paul MS, et al. Genesis, 2018 Oct. PMID 30246928
    4. Systematic assessment of transcriptomic and metabolic reprogramming by blue light exposure coupled with aging. Huang J, et al. PNAS Nexus, 2023 Dec. PMID 38059264, Free PMC Article
    5. Identification of genes that influence gurken expression. Geng C, et al. Fly (Austin), 2007 Sep-Oct. PMID 18836312

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables hexose transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in monosaccharide transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    sugar transporter 2
    Names
    CG17975-PA
    sut2-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      8087396..8089297
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079993.3 → NP_524732.1  sugar transporter 2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524732.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U622, Q9V361
      Related
      FBpp0087856
      Conserved Domains (2) summary
      cd06174
      Location:76 → 466
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam00083
      Location:23 → 473
      Sugar_tr; Sugar (and other) transporter
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9U622 Q9U622

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