U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    bsk basket [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44801, updated on 17-Dec-2024

    Summary

    Official Symbol
    bskprovided by FlyBase
    Official Full Name
    basketprovided by FlyBase
    Primary source
    FLYBASE:FBgn0000229
    Locus tag
    Dmel_CG5680
    See related
    AllianceGenome:FB:FBgn0000229
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Basket; Bsk; BSK; bsk/JNK; CG5680; D-JNK; D-junk; DBSK/JNK; dJnk; dJNK; DJNK; DJNK/bsk; Dmel\CG5680; DmJNK; dNJNK; Jak; JAK; jnk; Jnk; JNK; jnk (bsk); JNK/SAPK; Junk; p-JNK; P-JNK; pJNK; SAPK/JNK; SAPKa
    Summary
    Enables JUN kinase activity. Involved in several processes, including axonogenesis; defense response to other organism; and morphogenesis of an epithelium. Located in axon; dendrite; and nucleus. Is expressed in several structures, including embryonic/larval midgut primordium; epithelial furrow; head epidermis primordium; imaginal disc; and presumptive embryonic/larval system. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in several diseases, including abdominal aortic aneurysm; chronic mucocutaneous candidiasis; intestinal benign neoplasm (multiple); pancreatic adenocarcinoma; and type 2 diabetes mellitus. Orthologous to several human genes including MAPK10 (mitogen-activated protein kinase 10) and MAPK8 (mitogen-activated protein kinase 8). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See bsk in Genome Data Viewer
    Location:
    31B1-31B1; 2-40 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10247502..10250501, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10247502..10250501, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene maternal expression at 31B Neighboring gene antisense RNA:CR44995 Neighboring gene chico Neighboring gene uncharacterized protein Neighboring gene Ror Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding  
    enables JUN kinase activity  
    enables JUN kinase activity PubMed 
    enables JUN kinase activity PubMed 
    enables MAP kinase activity  
    enables protein binding PubMed 
    enables protein kinase activity PubMed 
    Items 1 - 25 of 48
    Process Evidence Code Pubs
    involved_in JNK cascade  
    involved_in JNK cascade PubMed 
    involved_in JNK cascade PubMed 
    involved_in antibacterial humoral response PubMed 
    involved_in axon extension PubMed 
    involved_in axon guidance PubMed 
    involved_in cellular response to arsenic-containing substance PubMed 
    involved_in cellular response to cadmium ion PubMed 
    involved_in cellular response to oxidative stress PubMed 
    involved_in cellular response to reactive oxygen species PubMed 
    NOT involved_in cellular response to starvation PubMed 
    involved_in chorion micropyle formation PubMed 
    involved_in collateral sprouting of injured axon PubMed 
    involved_in defense response to Gram-negative bacterium PubMed 
    involved_in determination of digestive tract left/right asymmetry PubMed 
    involved_in dorsal appendage formation PubMed 
    involved_in dorsal closure PubMed 
    involved_in dorsal closure PubMed 
    involved_in dorsal closure, spreading of leading edge cells PubMed 
    involved_in embryonic anterior midgut (ectodermal) morphogenesis PubMed 
    involved_in engulfment of apoptotic cell PubMed 
    involved_in follicle cell of egg chamber development PubMed 
    involved_in imaginal disc fusion, thorax closure PubMed 
    involved_in imaginal disc-derived male genitalia morphogenesis PubMed 
    involved_in long-term memory PubMed 
    involved_in melanization defense response PubMed 
    involved_in melanization defense response PubMed 
    involved_in mushroom body development PubMed 
    involved_in neuron development PubMed 
    involved_in neuron projection morphogenesis PubMed 
    involved_in peptidoglycan recognition protein signaling pathway PubMed 
    acts_upstream_of positive regulation of apoptotic process PubMed 
    acts_upstream_of positive regulation of autophagy PubMed 
    involved_in positive regulation of border follicle cell migration PubMed 
    involved_in positive regulation of border follicle cell migration PubMed 
    involved_in positive regulation of cell population proliferation PubMed 
    involved_in positive regulation of gene expression PubMed 
    involved_in positive regulation of neuron remodeling PubMed 
    acts_upstream_of positive regulation of programmed cell death PubMed 
    involved_in protein phosphorylation  
    involved_in regulation of cellular response to phosphate starvation PubMed 
    involved_in response to heat PubMed 
    involved_in response to oxidative stress PubMed 
    involved_in tumor necrosis factor-mediated signaling pathway PubMed 
    involved_in vascular endothelial growth factor receptor signaling pathway PubMed 
    involved_in wound healing PubMed 
    involved_in wound healing PubMed 
    involved_in wound healing, spreading of epidermal cells PubMed 
    Items 1 - 25 of 48
    Component Evidence Code Pubs
    located_in axon PubMed 
    is_active_in cytoplasm  
    located_in dendrite PubMed 
    is_active_in nucleus  
    located_in nucleus PubMed 

    General protein information

    Preferred Names
    basket
    Names
    CG5680-PB
    CG5680-PE
    CG5680-PF
    JNK
    JUN kinase
    Jun N-terminal kinase
    Jun NH2-terminal kinase
    Jun-N terminal kinase
    Jun-N-terminal kinase
    Jun-kinase
    bsk-PB
    bsk-PE
    bsk-PF
    c-Jun N-terminal kinase
    c-Jun aminoterminal kinase
    c-Jun-N-terminal kinase
    pJNK
    NP_001162930.1
    NP_001162932.1
    NP_723541.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      10247502..10250501 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_164900.3 → NP_723541.1  basket, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723541.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O01366, P92208, Q94542
      UniProtKB/TrEMBL
      E1JHD6
      Related
      FBpp0079676
      Conserved Domains (1) summary
      cd07850
      Location:23 → 359
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    2. NM_001169459.1 → NP_001162930.1  basket, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162930.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O01366, P92208, Q94542
      UniProtKB/TrEMBL
      E1JHD6
      Conserved Domains (1) summary
      cd07850
      Location:23 → 359
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    3. NM_001169461.3 → NP_001162932.1  basket, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162932.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O01366, P92208, Q94542
      UniProtKB/TrEMBL
      E1JHD6
      Conserved Domains (1) summary
      cd07850
      Location:23 → 359
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    Loading
    Loading
    External link. Please review our privacy policy.