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    CG14646 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40555, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG14646provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037241
    Locus tag
    Dmel_CG14646
    See related
    AllianceGenome:FB:FBgn0037241
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.373; Dmel\CG14646
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein polyubiquitination. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum. Is expressed in adult head and organism. Orthologous to human TMEM129 (transmembrane protein 129, E3 ubiquitin ligase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG14646 in Genome Data Viewer
    Location:
    82A5-82A5; 3-47.1 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (4390366..4392111)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (216088..217833)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Contactin Neighboring gene tube Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR46139 Neighboring gene antisense RNA:CR45999 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Loss of the endoplasmic reticulum protein Tmem208 affects cell polarity, development, and viability. Dutta D, et al. Proc Natl Acad Sci U S A, 2024 Feb 27. PMID 38381787, Free PMC Article
    2. Putative synaptic genes defined from a Drosophila whole body developmental transcriptome by a machine learning approach. Pazos Obregón F, et al. BMC Genomics, 2015 Sep 15. PMID 26370122, Free PMC Article
    3. CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans. Wei P, et al. Genome Res, 2020 Jan. PMID 31722958, Free PMC Article
    4. Phylostratigraphic bias creates spurious patterns of genome evolution. Moyers BA, et al. Mol Biol Evol, 2015 Jan. PMID 25312911, Free PMC Article
    5. High-fidelity promoter profiling reveals widespread alternative promoter usage and transposon-driven developmental gene expression. Batut P, et al. Genome Res, 2013 Jan. PMID 22936248, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    • Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein polyubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG14646-PA
    CG14646-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      4390366..4392111
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141205.3 → NP_649462.1  uncharacterized protein Dmel_CG14646, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649462.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95TM4, Q9VN16
      Related
      FBpp0078559
      Conserved Domains (1) summary
      pfam10272
      Location:19 → 384
      Tmpp129; Putative transmembrane protein precursor

    2. NM_001202236.2 → NP_001189165.1  uncharacterized protein Dmel_CG14646, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189165.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95TM4, Q9VN16
      Conserved Domains (1) summary
      pfam10272
      Location:19 → 384
      Tmpp129; Putative transmembrane protein precursor
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95TM4 Q95TM4
    Q9VN16 Q9VN16

    Gene LinkOut

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