Slc25a11 solute carrier family 25 (mitochondrial carrier oxoglutarate carrier), member 11 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc25a11provided by MGI
Official Full Name: solute carrier family 25 (mitochondrial carrier oxoglutarate carrier), member 11provided by MGI
Primary source: MGI:MGI:1915113
See related: Ensembl:ENSMUSG00000014606 AllianceGenome:MGI:1915113
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2oxoc; 2310022P18Rik
Summary: Enables oxoglutarate:malate antiporter activity. Involved in gluconeogenesis and malate-aspartate shuttle. Located in mitochondrion. Is active in mitochondrial inner membrane. Is expressed in embryo. Human ortholog(s) of this gene implicated in paraganglioma. Orthologous to human SLC25A11 (solute carrier family 25 member 11). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in heart adult (RPKM 208.5), kidney adult (RPKM 85.6) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B3; 11 43.21 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (70534845..70538356, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (70644019..70647531, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cancer cells critically depended on the oxoglutarate carrier SLC25A11 for transporting NADH from cytosol to mitochondria as a malate form for the purpose of ATP production
Title: Loss of SLC25A11 causes suppression of NSCLC and melanoma tumor formation.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation
Gene trapped (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:547034

Slc25a11 (e-PCR), detects polymorphism
- UniSTS:547034

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables alpha-ketoglutarate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables oxoglutarate:malate antiporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables oxoglutarate:malate antiporter activity	ISO Inferred from Sequence Orthology more info	PubMed
enables transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in alpha-ketoglutarate transport	IEA Inferred from Electronic Annotation more info
involved_in gluconeogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gluconeogenesis	ISO Inferred from Sequence Orthology more info	PubMed
involved_in lipid transport	IEA Inferred from Electronic Annotation more info
involved_in malate transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in malate-aspartate shuttle	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	HDA more info	PubMed
is_active_in mitochondrial inner membrane	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info	PubMed
located_in mitochondrion	HDA more info	PubMed

General protein information

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Preferred Names: mitochondrial 2-oxoglutarate/malate carrier protein

Names: OGCP; alpha-oxoglutarate carrier; solute carrier family 25 member 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.