Mif macrophage migration inhibitory factor [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Mifprovided by RGD
Full Name: macrophage migration inhibitory factorprovided by RGD
Primary source: RGD:621163
See related: AllianceGenome:RGD:621163
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including identical protein binding activity; intramolecular oxidoreductase activity; and receptor ligand activity. Involved in several processes, including brain renin-angiotensin system; positive regulation of glycolytic process; and positive regulation of transport. Located in extracellular space. Used to study several diseases, including acute necrotizing pancreatitis; cardiomyopathy (multiple); lung disease (multiple); retinitis; and toxic shock syndrome. Biomarker of borna disease; cystitis; kidney disease; myocardial infarction; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in allergic disease; asthma; cystic fibrosis; lung disease (multiple); and obesity. Orthologous to human MIF (macrophage migration inhibitory factor). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 573.4), Brain (RPKM 421.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20p12

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (12767138..12791222)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (12790919..12791784)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (13715219..13732980)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MIF inhibition attenuates intervertebral disc degeneration by reducing nucleus pulposus cell apoptosis and inflammation.
Title: MIF inhibition attenuates intervertebral disc degeneration by reducing nucleus pulposus cell apoptosis and inflammation.
Macrophage migration inhibitory factor exacerbates asthmatic airway remodeling via dynamin-related protein 1-mediated autophagy activation.
Title: Macrophage migration inhibitory factor exacerbates asthmatic airway remodeling via dynamin-related protein 1-mediated autophagy activation.
Exosomes from adipose-derived stem cells regulate M1/M2 macrophage phenotypic polarization to promote bone healing via miR-451a/MIF.
Title: Exosomes from adipose-derived stem cells regulate M1/M2 macrophage phenotypic polarization to promote bone healing via miR-451a/MIF.
Macrophage migration inhibitory factor regulates joint capsule fibrosis by promoting TGF-beta1 production in fibroblasts.
Title: Macrophage migration inhibitory factor regulates joint capsule fibrosis by promoting TGF-β1 production in fibroblasts.
MIF-mediated NF-kappaB signaling pathway regulates the pathogenesis of polycystic ovary syndrome in rats.
Title: MIF-mediated NF-κB signaling pathway regulates the pathogenesis of polycystic ovary syndrome in rats.
Inhibition of Macrophage Migration Inhibitory Factor Protects against Inflammation through a Toll-like Receptor-Related Pathway after Diffuse Axonal Injury in Rats.
Title: Inhibition of Macrophage Migration Inhibitory Factor Protects against Inflammation through a Toll-like Receptor-Related Pathway after Diffuse Axonal Injury in Rats.
Exosomes from mesenchymal stem cells overexpressing MIF enhance myocardial repair.
Title: Exosomes from mesenchymal stem cells overexpressing MIF enhance myocardial repair.
The Role of Macrophage Migration Inhibitory Factor in Remote Ischemic Conditioning Induced Hepatoprotection in a Rodent Model of Liver Transplantation.
Title: The Role of Macrophage Migration Inhibitory Factor in Remote Ischemic Conditioning Induced Hepatoprotection in a Rodent Model of Liver Transplantation.
novel role of MIF in eliciting inflammatory response of peripheral nerve injury
Title: MIF/CD74 axis participates in inflammatory activation of Schwann cells following sciatic nerve injury.
MIF may promote intrahepatic bile duct injury and inflammatory reaction in severe acute pancreatitis by activating the P38-MAPK and NF-kappaB signaling pathways.
Title: Macrophage Migration Inhibitor Promoted the Intrahepatic Bile Duct Injury in Rats with Severe Acute Pancreatitis.

Submit: New GeneRIF Correction See all GeneRIFs (60)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables chemoattractant activity	ISO Inferred from Sequence Orthology more info
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine activity	IEA Inferred from Electronic Annotation more info
enables cytokine activity	ISO Inferred from Sequence Orthology more info
enables cytokine receptor binding	ISO Inferred from Sequence Orthology more info
enables dopachrome isomerase activity	ISO Inferred from Sequence Orthology more info
enables dopachrome isomerase activity	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables isomerase activity	IEA Inferred from Electronic Annotation more info
enables phenylpyruvate tautomerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phenylpyruvate tautomerase activity	ISO Inferred from Sequence Orthology more info
enables protease binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response, signal transduction by p53 class mediator	ISO Inferred from Sequence Orthology more info
involved_in brain renin-angiotensin system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in carboxylic acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hydrogen peroxide	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within cellular senescence	ISO Inferred from Sequence Orthology more info
involved_in drinking behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hair follicle development	IEP Inferred from Expression Pattern more info	PubMed
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA damage response, signal transduction by p53 class mediator	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cellular senescence	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of macrophage chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mature B cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of myeloid cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein metabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of B cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of D-glucose import	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAP kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of acute inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of arachidonate secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of axon regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cAMP/PKA signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of chemokine (C-X-C motif) ligand 2 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fibroblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of glycolytic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of lipopolysaccharide-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of myeloid leukocyte cytokine production involved in immune response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of potassium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of prostaglandin secretion involved in immune response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in prostaglandin biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in protein homotrimerization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to glucocorticoid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to insulin	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to mechanical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to menaquinone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to progesterone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to vitamin E	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in skin development	IEP Inferred from Expression Pattern more info	PubMed
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: macrophage migration inhibitory factor

Names: L-dopachrome isomerase; L-dopachrome tautomerase; glutathione-binding 13 kDa protein; macrophage migration inhibitory factor (glycosylation-inhibiting factor); phenylpyruvate tautomerase

NP_112313.1

EC 5.3.2.1

EC 5.3.3.12

XP_063135631.1

EC 5.3.2.1

EC 5.3.3.12

XP_063135632.1

EC 5.3.2.1

EC 5.3.3.12

XP_063135633.1

EC 5.3.2.1

EC 5.3.3.12

XP_063135634.1

EC 5.3.2.1

EC 5.3.3.12

XP_063135635.1

EC 5.3.2.1

EC 5.3.3.12

XP_063135636.1

EC 5.3.2.1

EC 5.3.3.12

XP_063135637.1

EC 5.3.2.1

EC 5.3.3.12

XP_063135638.1

EC 5.3.2.1

EC 5.3.3.12

XP_063135639.1

EC 5.3.2.1

EC 5.3.3.12

XP_063135640.1

EC 5.3.2.1

EC 5.3.3.12

XP_063135641.1

EC 5.3.2.1

EC 5.3.3.12

XP_063135642.1

EC 5.3.2.1

EC 5.3.3.12

XP_063135643.1

EC 5.3.2.1

EC 5.3.3.12

XP_063135644.1

EC 5.3.2.1

EC 5.3.3.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031051.2 → NP_112313.1 macrophage migration inhibitory factor

See identical proteins and their annotated locations for NP_112313.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000020

UniProtKB/Swiss-Prot

P30904

UniProtKB/TrEMBL

A0A0F7RQL3, D4A3P7

Conserved Domains (1) summary

pfam01187
Location:2 → 115

MIF; Macrophage migration inhibitory factor (MIF)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086038.1 Reference GRCr8

Range

12767138..12791222

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063279572.1 → XP_063135642.1 macrophage migration inhibitory factor isoform X2

UniProtKB/Swiss-Prot

P30904

UniProtKB/TrEMBL

A0A0F7RQL3, D4A3P7
XM_063279566.1 → XP_063135636.1 macrophage migration inhibitory factor isoform X2

UniProtKB/Swiss-Prot

P30904

UniProtKB/TrEMBL

A0A0F7RQL3, D4A3P7
XM_063279565.1 → XP_063135635.1 macrophage migration inhibitory factor isoform X2

UniProtKB/Swiss-Prot

P30904

UniProtKB/TrEMBL

A0A0F7RQL3, D4A3P7
XM_063279570.1 → XP_063135640.1 macrophage migration inhibitory factor isoform X2

UniProtKB/Swiss-Prot

P30904

UniProtKB/TrEMBL

A0A0F7RQL3, D4A3P7
XM_063279571.1 → XP_063135641.1 macrophage migration inhibitory factor isoform X2

UniProtKB/Swiss-Prot

P30904

UniProtKB/TrEMBL

A0A0F7RQL3, D4A3P7
XM_063279567.1 → XP_063135637.1 macrophage migration inhibitory factor isoform X2

UniProtKB/Swiss-Prot

P30904

UniProtKB/TrEMBL

A0A0F7RQL3, D4A3P7
XM_063279564.1 → XP_063135634.1 macrophage migration inhibitory factor isoform X1
XM_063279568.1 → XP_063135638.1 macrophage migration inhibitory factor isoform X2

UniProtKB/Swiss-Prot

P30904

UniProtKB/TrEMBL

A0A0F7RQL3, D4A3P7
XM_063279561.1 → XP_063135631.1 macrophage migration inhibitory factor isoform X1
XM_063279574.1 → XP_063135644.1 macrophage migration inhibitory factor isoform X2

UniProtKB/Swiss-Prot

P30904

UniProtKB/TrEMBL

A0A0F7RQL3, D4A3P7
XM_063279562.1 → XP_063135632.1 macrophage migration inhibitory factor isoform X1
XM_063279563.1 → XP_063135633.1 macrophage migration inhibitory factor isoform X1
XM_063279569.1 → XP_063135639.1 macrophage migration inhibitory factor isoform X2

UniProtKB/Swiss-Prot

P30904

UniProtKB/TrEMBL

A0A0F7RQL3, D4A3P7
XM_063279573.1 → XP_063135643.1 macrophage migration inhibitory factor isoform X2

UniProtKB/Swiss-Prot

P30904

UniProtKB/TrEMBL

A0A0F7RQL3, D4A3P7