Gata6 GATA binding protein 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29300, updated on 9-Dec-2024

Summary

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Official Symbol: Gata6provided by RGD
Official Full Name: GATA binding protein 6provided by RGD
Primary source: RGD:2666
See related: EnsemblRapid:ENSRNOG00000023433 AllianceGenome:RGD:2666
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables DNA-binding transcription factor binding activity and cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including positive regulation of BMP signaling pathway; positive regulation of cardiac muscle cell apoptotic process; and regulation of DNA-templated transcription. Predicted to be located in nuclear membrane and nucleoplasm. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Biomarker of congenital diaphragmatic hernia and pulmonary hypertension. Human ortholog(s) of this gene implicated in adenocarcinoma (multiple); congenital heart disease (multiple); and pancreatic hypoplasia-diabetes-congenital heart disease syndrome. Orthologous to human GATA6 (GATA binding protein 6). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 211.1), Adrenal (RPKM 136.4) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

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See Gata6 in Genome Data Viewer

Location:: 18p13

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (2460909..2492322)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (2188121..2219532)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (2415821..2447087)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GATA6 promotes fibrotic repair of tracheal injury through NLRP3 inflammasome-mediated epithelial pyroptosis.
Title: GATA6 promotes fibrotic repair of tracheal injury through NLRP3 inflammasome-mediated epithelial pyroptosis.
GATA6 Inhibits Neuronal Autophagy and Ferroptosis in Cerebral ischemia-reperfusion Injury Through a miR-193b/ATG7 axis-dependent Mechanism.
Title: GATA6 Inhibits Neuronal Autophagy and Ferroptosis in Cerebral ischemia-reperfusion Injury Through a miR-193b/ATG7 axis-dependent Mechanism.
GATA4/6 regulate DHH transcription in rat adrenocortical autografts.
Title: GATA4/6 regulate DHH transcription in rat adrenocortical autografts.
GATA6 and StAR steroidogeneic genes are hypomethylated at specific CpG sites in prenatally androgenized rats
Title: Hypomethylation of specific CpG sites in the promoter region of steroidogeneic genes (GATA6 and StAR) in prenatally androgenized rats.
Elevated expression of steroidogenesis pathway genes; CYP17, GATA6 and StAR in prenatally androgenized rats.
Title: Elevated expression of steroidogenesis pathway genes; CYP17, GATA6 and StAR in prenatally androgenized rats.
Sulforaphane can inhibit transcription factors GATA4/6 as well as p-JNK1/2 and p-ERK1/2 MAPK signaling pathways in the cardiomyocytes.
Title: Sulforaphane suppresses cardiac hypertrophy by inhibiting GATA4/GATA6 expression and MAPK signaling pathways.
These results establish SHP as a novel antihypertrophic regulator that acts by interfering with GATA6 signaling.
Title: Small heterodimer partner blocks cardiac hypertrophy by interfering with GATA6 signaling.
In this study, they examined whether or not the JNK signaling pathway participates in the cAMP-dependent proteolysis of GATA-6 since a JNK inhibitor, SP600125, inhibited the proteolysis.
Title: cAMP-dependent proteolysis of GATA-6 is linked to JNK-signaling pathway.
Simvastatin restores down-regulated GATA-6 expression in pulmonary hypertensive rats.
Title: Simvastatin restores down-regulated GATA-6 expression in pulmonary hypertensive rats.
GATA-6 mediates transcriptional activation of aquaporin-5 through interactions with Sp1.
Title: GATA-6 mediates transcriptional activation of aquaporin-5 through interactions with Sp1.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Gata6 (e-PCR), detects polymorphism
- UniSTS:516402

RH94728 (e-PCR)
- UniSTS:119975

RH124933 (e-PCR)
- UniSTS:161755

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables NFAT protein binding	IEA Inferred from Electronic Annotation more info
enables NFAT protein binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	IEA Inferred from Electronic Annotation more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info
enables transcription coactivator binding	IEA Inferred from Electronic Annotation more info
enables transcription coactivator binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G1 to G0 transition involved in cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within_negative_effect G1 to G0 transition involved in cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in animal organ formation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within animal organ formation	ISO Inferred from Sequence Orthology more info
involved_in cardiac muscle cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cardiac muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in cardiac muscle cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of cardiac muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in cardiac muscle hypertrophy in response to stress	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cardiac muscle hypertrophy in response to stress	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cardiac muscle tissue development	ISO Inferred from Sequence Orthology more info
involved_in cardiac vascular smooth muscle cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cardiac vascular smooth muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in cell fate commitment	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to BMP stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to BMP stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to gonadotropin stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to gonadotropin stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hypoxia	IEA Inferred from Electronic Annotation more info
involved_in cellular response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in club cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within club cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within endodermal cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in endodermal cell fate determination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within endodermal cell fate determination	ISO Inferred from Sequence Orthology more info
involved_in epithelial cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in gene expression	IEA Inferred from Electronic Annotation more info
involved_in gene expression	ISO Inferred from Sequence Orthology more info
involved_in heart contraction	IEA Inferred from Electronic Annotation more info
involved_in heart contraction	ISO Inferred from Sequence Orthology more info
involved_in in utero embryonic development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
involved_in intestinal epithelial cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within intestinal epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in liver development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within liver development	ISO Inferred from Sequence Orthology more info
involved_in lung saccule development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lung saccule development	ISO Inferred from Sequence Orthology more info
involved_in male gonad development	IEA Inferred from Electronic Annotation more info
involved_in male gonad development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of miRNA transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of sebum secreting cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of sebum secreting cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transforming growth factor beta1 production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transforming growth factor beta1 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transforming growth factor beta2 production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transforming growth factor beta2 production	ISO Inferred from Sequence Orthology more info
involved_in odontogenesis of dentin-containing tooth	IEP Inferred from Expression Pattern more info	PubMed
involved_in outflow tract septum morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in outflow tract septum morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within pancreas development	ISO Inferred from Sequence Orthology more info
involved_in pancreatic A cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within pancreatic A cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in phospholipid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phospholipid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of BMP signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cardiac muscle cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cardiac muscle cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of cardiac muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cardiac muscle myoblast proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cardiac muscle myoblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of antimicrobial humoral response	IEA Inferred from Electronic Annotation more info
involved_in regulation of antimicrobial humoral response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in response to cAMP	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to estrogen	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to estrogen	ISO Inferred from Sequence Orthology more info
involved_in response to growth factor	ISO Inferred from Sequence Orthology more info
involved_in response to retinoic acid	IEA Inferred from Electronic Annotation more info
involved_in response to retinoic acid	ISO Inferred from Sequence Orthology more info
involved_in response to toxic substance	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEA Inferred from Electronic Annotation more info
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
involved_in sebaceous gland cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in sebaceous gland cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in sinoatrial node development	IEA Inferred from Electronic Annotation more info
involved_in sinoatrial node development	ISO Inferred from Sequence Orthology more info
involved_in skin epidermis development	IEA Inferred from Electronic Annotation more info
involved_in skin epidermis development	ISO Inferred from Sequence Orthology more info
involved_in smooth muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in stem cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within stem cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in tube morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within tube morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in type B pancreatic cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within type B pancreatic cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in type II pneumocyte differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within type II pneumocyte differentiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of transcription regulator complex	IEA Inferred from Electronic Annotation more info
part_of transcription regulator complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: transcription factor GATA-6

Names: DNA-binding protein GATA-GT2; GATA-binding factor 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019185.2 → NP_062058.2 transcription factor GATA-6

See identical proteins and their annotated locations for NP_062058.2

Status: VALIDATED

Source sequence(s)

AI712574, JAXUCZ010000018, L22760

UniProtKB/Swiss-Prot

P46153

Related

ENSRNOP00000070439.2, ENSRNOT00000081399.3

Conserved Domains (3) summary

smart00401
Location:435 → 482

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd00202
Location:437 → 488

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

pfam05349
Location:147 → 371

GATA-N; GATA-type transcription activator, N-terminal