Gja6 gap junction protein, alpha 6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gja6provided by RGD
Official Full Name: gap junction protein, alpha 6provided by RGD
Primary source: RGD:2693
See related: AllianceGenome:RGD:2693
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: cx33; Cxnk2; cxn-33
Summary: Predicted to enable gap junction channel activity. Predicted to be involved in cell communication by electrical coupling; cell-cell signaling; and heart development. Predicted to be part of connexin complex. Human ortholog(s) of this gene implicated in several diseases, including bone disease (multiple); erythrokeratodermia variabilis (multiple); hypoplastic left heart syndrome; oculodentodigital dysplasia; and palmoplantar keratoderma and congenital alopecia 1. Orthologous to human GJA1 (gap junction protein alpha 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 21.8), Testes (RPKM 21.2) and 9 other tissues See more
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Genomic context

Location:: Xq14

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (37649393..37654289)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (33840689..33845585)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (35621805..35622665)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that in the testis, connexin33 could exert a specific role on germ cell proliferation by suppressing the regulatory effect of connexin43.
Title: Dominant negative effect of connexin33 on gap junctional communication is mediated by connexin43 sequestration.
Cx33 and Cx43 genes are controlled differently within the testis and suggest that these two Cxs may exert opposite and complementary effects on spermatogenesis.
Title: Opposite regulation of connexin33 and connexin43 by LPS and IL-1alpha in spermatogenesis.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables gap junction channel activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell communication by electrical coupling	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in heart development	IBA Inferred from Biological aspect of Ancestor more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of connexin complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: gap junction alpha-6 protein

Names: connexin k2; connexin-33; gap junction membrane channel protein alpha 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.