Igfbp5 insulin-like growth factor binding protein 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Igfbp5provided by RGD
Official Full Name: insulin-like growth factor binding protein 5provided by RGD
Primary source: RGD:2876
See related: EnsemblRapid:ENSRNOG00000017206 AllianceGenome:RGD:2876
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: IGF-BP5
Summary: Enables insulin-like growth factor binding activity. Involved in intracellular signal transduction and response to organic cyclic compound. Predicted to be located in cytoplasm and nucleus. Predicted to be part of insulin-like growth factor ternary complex. Predicted to be active in extracellular space. Biomarker of congenital diaphragmatic hernia. Orthologous to human IGFBP5 (insulin like growth factor binding protein 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 1494.7), Uterus (RPKM 1430.8) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q33

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (81901605..81914187, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (74452371..74464953, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (80154230..80166813, complement)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The expression of IGFBP-5 in the reproductive axis and effect on the onset of puberty in female rats.
Title: The expression of IGFBP-5 in the reproductive axis and effect on the onset of puberty in female rats.
Homocysteine downregulates cardiac homeobox transcription factor NKX2.5 via IGFBP5.
Title: Homocysteine downregulates cardiac homeobox transcription factor NKX2.5 via IGFBP5.
Overexpressed IGFBP5 promotes cell proliferation and inhibits apoptosis of nucleus pulposus derived from rats with disc degeneration through inactivating the ERK/MAPK axis.
Title: Overexpressed IGFBP5 promotes cell proliferation and inhibits apoptosis of nucleus pulposus derived from rats with disc degeneration through inactivating the ERK/MAPK axis.
IGFBP5 was determined as a target of miR-24-3p, and IGFBP5 knockdown induced effects on NP cells similar to those induced by miR-24-3p
Title: miR-24-3p induces human intervertebral disc degeneration by targeting insulin-like growth factor binding protein 5 and the ERK signaling pathway.
Insulin growth factor binding protein 5 (IGFBP-5), insulin growth factor (IGF-1) and transforming growth factor (TGF-beta1) in the type II alveolar epithelial cells (AECs) play a key role in lung injury caused by bleomycin and pioglitazone attenuates the lung injury/fibrosis by restoring IGFBP-5 and IGF-1 and decreasing TGF-beta1 expressions in the type II AECs.
Title: Role of insulin like growth factor axis in the bleomycin induced lung injury in rats.
Silencing IGFBP5 with small interfering RNA significantly reduced apoptosis and suppressed the expression of caspase3 in neonatal rat ventricular myocytes following treatment with methamphetamine.
Title: Critical role of insulin‑like growth factor binding protein‑5 in methamphetamine‑induced apoptosis in cardiomyocytes.
IGFBP5 expression was up-regulated in the striatum of methamphetamine exposed male Sprague-Dawley rats.
Title: Insulin-like growth factor binding protein 5 (IGFBP5) mediates methamphetamine-induced dopaminergic neuron apoptosis.
IGFBP5 mediates high glucose-induced cardiac fibroblast activation
Title: IGFBP5 mediates high glucose-induced cardiac fibroblast activation.
IGFs/IGFBPs may have important roles not only in fracture healing but also in nonunion formation.
Title: Differential gene expression and immunolocalization of insulin-like growth factors and insulin-like growth factor binding proteins between experimental nonunions and standard healing fractures.
Insulin-like growth factor-binding protein-5-induced laminin gamma1 transcription requires filamin A.
Title: Insulin-like growth factor-binding protein-5-induced laminin gamma1 transcription requires filamin A.

Submit: New GeneRIF Correction See all GeneRIFs (21)

General gene information

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Markers

AA963598 (e-PCR)
- UniSTS:248083

RH75182 (e-PCR)
- UniSTS:85051

PMC85624P4 (e-PCR)
- UniSTS:273484

Igfbp5 (e-PCR), detects polymorphism
- UniSTS:143490

RH127562 (e-PCR)
- UniSTS:210872

RH94791 (e-PCR)
- UniSTS:120038

D9Wox32 (e-PCR)
- UniSTS:240381

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables fibronectin binding	IBA Inferred from Biological aspect of Ancestor more info
enables fibronectin binding	ISO Inferred from Sequence Orthology more info
enables insulin-like growth factor I binding	IBA Inferred from Biological aspect of Ancestor more info
enables insulin-like growth factor I binding	ISO Inferred from Sequence Orthology more info
enables insulin-like growth factor II binding	IBA Inferred from Biological aspect of Ancestor more info
enables insulin-like growth factor binding	IDA Inferred from Direct Assay more info	PubMed
enables insulin-like growth factor binding	ISO Inferred from Sequence Orthology more info
enables receptor ligand activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to cAMP	ISO Inferred from Sequence Orthology more info
involved_in cellular response to organic cyclic compound	ISO Inferred from Sequence Orthology more info
involved_in female pregnancy	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glucose homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hair follicle morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of insulin-like growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	IEP Inferred from Expression Pattern more info	PubMed
involved_in lung alveolus development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mammary gland involution	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of growth	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of insulin-like growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of insulin-like growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of muscle tissue development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of skeletal muscle hypertrophy	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of smooth muscle cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in osteoblast differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of insulin-like growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular associated smooth muscle cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular associated smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cell growth	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of growth	ISO Inferred from Sequence Orthology more info
involved_in regulation of insulin-like growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to growth hormone	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within striated muscle cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within type B pancreatic cell proliferation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
part_of insulin-like growth factor ternary complex	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: insulin-like growth factor-binding protein 5

Names: IBP-5; IGF-binding protein 5; IGFBP-5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012817.2 → NP_036949.1 insulin-like growth factor-binding protein 5 precursor

See identical proteins and their annotated locations for NP_036949.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000009

UniProtKB/Swiss-Prot

P24594

UniProtKB/TrEMBL

A6JVR0

Related

ENSRNOP00000023530.3, ENSRNOT00000023530.8

Conserved Domains (2) summary

smart00121
Location:24 → 100

IB; Insulin growth factor-binding protein homologues

pfam00086
Location:191 → 262

Thyroglobulin_1; Thyroglobulin type-1 repeat