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    Hebp1 heme binding protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362454, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hebp1provided by RGD
    Official Full Name
    heme binding protein 1provided by RGD
    Primary source
    RGD:1304581
    See related
    EnsemblRapid:ENSRNOG00000000024 AllianceGenome:RGD:1304581
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable heme binding activity. Predicted to be located in cytosol and mitochondrion. Orthologous to human HEBP1 (heme binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 150.7), Spleen (RPKM 116.2) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Hebp1 in Genome Data Viewer
    Location:
    4q43
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (169705665..169735199, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (167974316..168003854, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (168903586..168933102, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor, class C, group 5, member D Neighboring gene ribosomal protein S17, pseudogene 7 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene family with sequence similarity 234, member B Neighboring gene germ cell associated 1 Neighboring gene phosphatidylethanolamine binding protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Molecular characterization of a newly identified heme-binding protein induced during differentiation of urine erythroleukemia cells. Taketani S, et al. J Biol Chem, 1998 Nov 20. PMID 9813049
    2. The first structure from the SOUL/HBP family of heme-binding proteins, murine P22HBP. Dias JS, et al. J Biol Chem, 2006 Oct 20. PMID 16905545
    3. Characterization of a human and mouse tetrapyrrole-binding protein. Jacob Blackmon B, et al. Arch Biochem Biophys, 2002 Nov 15. PMID 12413491
    4. Discovery of a putative heme-binding protein family (SOUL/HBP) by two-tissue suppression subtractive hybridization and database searches. Zylka MJ, et al. Brain Res Mol Brain Res, 1999 Dec 10. PMID 10640688
    5. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables heme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    heme-binding protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108651.1 → NP_001102121.1  heme-binding protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001102121.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473964
      UniProtKB/TrEMBL
      A6IMF8
      Conserved Domains (1) summary
      pfam04832
      Location:30 → 131
      SOUL; SOUL heme-binding protein

    2. NM_001398876.1 → NP_001385805.1  heme-binding protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A9K3Y6Z3, B4F7C7, F7EVC6
      Related
      ENSRNOP00000000025.7, ENSRNOT00000000025.9
      Conserved Domains (1) summary
      pfam04832
      Location:13 → 188
      SOUL; SOUL heme-binding protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      169705665..169735199 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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