Kyat3 kynurenine aminotransferase 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kyat3provided by RGD
Official Full Name: kynurenine aminotransferase 3provided by RGD
Primary source: RGD:1359262
See related: EnsemblRapid:ENSRNOG00000043426 AllianceGenome:RGD:1359262
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Kat3; Ccbl2
Summary: Predicted to enable kynurenine-glyoxylate transaminase activity; kynurenine-oxoglutarate transaminase activity; and protein homodimerization activity. Predicted to be involved in 2-oxoglutarate metabolic process and kynurenine metabolic process. Predicted to be active in mitochondrion. Orthologous to human KYAT3 (kynurenine aminotransferase 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 779.5), Kidney (RPKM 151.7) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q44

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (234362306..234407646)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (231701881..231747462)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (248644473..248690289)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

D2Rat151 (e-PCR), detects polymorphism
- UniSTS:227340

RH140542 (e-PCR)
- UniSTS:222611

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cysteine-S-conjugate beta-lyase activity	IEA Inferred from Electronic Annotation more info
enables kynurenine-glyoxylate transaminase activity	IEA Inferred from Electronic Annotation more info
enables kynurenine-glyoxylate transaminase activity	ISO Inferred from Sequence Orthology more info
enables kynurenine-glyoxylate transaminase activity	ISS Inferred from Sequence or Structural Similarity more info
enables kynurenine-oxoglutarate transaminase activity	IBA Inferred from Biological aspect of Ancestor more info
enables kynurenine-oxoglutarate transaminase activity	IEA Inferred from Electronic Annotation more info
enables kynurenine-oxoglutarate transaminase activity	ISO Inferred from Sequence Orthology more info
enables kynurenine-oxoglutarate transaminase activity	ISS Inferred from Sequence or Structural Similarity more info
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in 2-oxoglutarate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in 2-oxoglutarate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in L-kynurenine catabolic process	IEA Inferred from Electronic Annotation more info
involved_in amino acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in amino acid metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in biological_process	ND No biological Data available more info
involved_in biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in kynurenine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in kynurenine metabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: kynurenine--oxoglutarate transaminase 3

Names: KATIII; cysteine conjugate-beta lyase 2; cysteine-S-conjugate beta-lyase 2; kynurenine aminotransferase III; kynurenine aminotransferase III-like; kynurenine--glyoxylate transaminase; kynurenine--oxoglutarate transaminase III

NP_001015037.1

EC 2.6.1.63

EC 2.6.1.7

EC 4.4.1.13

XP_038958899.1

EC 2.6.1.63

EC 2.6.1.7

EC 4.4.1.13

XP_038958900.1

EC 2.6.1.63

EC 2.6.1.7

EC 4.4.1.13

XP_038958902.1

EC 2.6.1.63

EC 2.6.1.7

EC 4.4.1.13

XP_038958903.1

EC 2.6.1.63

EC 2.6.1.7

EC 4.4.1.13

XP_038958904.1

EC 2.6.1.63

EC 2.6.1.7

EC 4.4.1.13

XP_038958905.1

EC 2.6.1.63

EC 2.6.1.7

EC 4.4.1.13

XP_063138487.1

EC 2.6.1.63

EC 2.6.1.7

EC 4.4.1.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001015037.1 → NP_001015037.1 kynurenine--oxoglutarate transaminase 3

See identical proteins and their annotated locations for NP_001015037.1

Status: PROVISIONAL

Source sequence(s)

AY955395

UniProtKB/Swiss-Prot

Q58FK9

Related

ENSRNOP00000103048.1, ENSRNOT00000153006.1

Conserved Domains (2) summary

cd00609
Location:66 → 447

AAT_like; Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine ...

PRK07777
Location:44 → 452

PRK07777; aminotransferase; Validated

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

234362306..234407646

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039102972.2 → XP_038958900.1 kynurenine--oxoglutarate transaminase 3 isoform X2

Conserved Domains (1) summary

PRK07777
Location:10 → 418

PRK07777; putative succinyldiaminopimelate transaminase DapC
XM_039102977.2 → XP_038958905.1 kynurenine--oxoglutarate transaminase 3 isoform X4

Conserved Domains (1) summary

PRK08912
Location:3 → 298

PRK08912; aminotransferase
XM_039102971.2 → XP_038958899.1 kynurenine--oxoglutarate transaminase 3 isoform X1

UniProtKB/TrEMBL

A0A8I5ZUT0, A6HW71

Conserved Domains (1) summary

PRK07777
Location:44 → 452

PRK07777; putative succinyldiaminopimelate transaminase DapC
XM_063282417.1 → XP_063138487.1 kynurenine--oxoglutarate transaminase 3 isoform X2
XM_039102974.2 → XP_038958902.1 kynurenine--oxoglutarate transaminase 3 isoform X2

Related

ENSRNOP00000108974.1, ENSRNOT00000149481.1

Conserved Domains (1) summary

PRK07777
Location:10 → 418

PRK07777; putative succinyldiaminopimelate transaminase DapC
XM_039102975.2 → XP_038958903.1 kynurenine--oxoglutarate transaminase 3 isoform X2

Conserved Domains (1) summary

PRK07777
Location:10 → 418

PRK07777; putative succinyldiaminopimelate transaminase DapC
XM_039102976.2 → XP_038958904.1 kynurenine--oxoglutarate transaminase 3 isoform X3

Related

ENSRNOP00000083094.2, ENSRNOT00000101068.2

Conserved Domains (1) summary

PRK08912
Location:17 → 410

PRK08912; aminotransferase