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    Dscc1 DNA replication and sister chromatid cohesion 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 299933, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dscc1provided by RGD
    Official Full Name
    DNA replication and sister chromatid cohesion 1provided by RGD
    Primary source
    RGD:1561749
    See related
    EnsemblRapid:ENSRNOG00000026502 AllianceGenome:RGD:1561749
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1561749
    Summary
    Predicted to contribute to DNA clamp loader activity and single-stranded DNA helicase activity. Predicted to be involved in maintenance of mitotic sister chromatid cohesion; positive regulation of DNA-directed DNA polymerase activity; and post-translational protein acetylation. Predicted to be located in chromatin and nucleoplasm. Predicted to be part of Ctf18 RFC-like complex. Predicted to be active in chromosome, centromeric region. Orthologous to human DSCC1 (DNA replication and sister chromatid cohesion 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 69.4), Spleen (RPKM 47.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dscc1 in Genome Data Viewer
    Location:
    7q32
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (88372349..88390815, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (86482588..86498212, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (94759076..94774787, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120093657 Neighboring gene TATA-box binding protein associated factor 2 Neighboring gene uncharacterized LOC134479906 Neighboring gene large ribosomal subunit protein uL30-like Neighboring gene H3 histone, family 3C Neighboring gene DEP domain containing MTOR-interacting protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cohesin acetylation speeds the replication fork. Terret ME, et al. Nature, 2009 Nov 12. PMID 19907496, Free PMC Article
    2. The alternative Ctf18-Dcc1-Ctf8-replication factor C complex required for sister chromatid cohesion loads proliferating cell nuclear antigen onto DNA. Bermudez VP, et al. Proc Natl Acad Sci U S A, 2003 Sep 2. PMID 12930902, Free PMC Article
    3. Human Scc4 is required for cohesin binding to chromatin, sister-chromatid cohesion, and mitotic progression. Watrin E, et al. Curr Biol, 2006 May 9. PMID 16682347
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    contributes_to DNA clamp loader activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to single-stranded DNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA duplex unwinding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in maintenance of mitotic sister chromatid cohesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maintenance of mitotic sister chromatid cohesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-directed DNA polymerase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in post-translational protein acetylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of Ctf18 RFC-like complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Ctf18 RFC-like complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in chromosome, centromeric region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromosome, centromeric region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    sister chromatid cohesion protein DCC1
    Names
    defective in sister chromatid cohesion 1 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001305236.1 → NP_001292165.1  sister chromatid cohesion protein DCC1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      D4ACA3
      Related
      ENSRNOP00000105245.1, ENSRNOT00000163367.1
      Conserved Domains (1) summary
      pfam09724
      Location:49 → 363
      Dcc1; Sister chromatid cohesion protein Dcc1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      88372349..88390815 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063263252.1 → XP_063119322.1  sister chromatid cohesion protein DCC1 isoform X2

      UniProtKB/TrEMBL
      D4ACA3
      Related
      ENSRNOP00000108651.1, ENSRNOT00000125966.1

    2. XM_039078787.2 → XP_038934715.1  sister chromatid cohesion protein DCC1 isoform X3

      UniProtKB/TrEMBL
      A6HRG8
      Conserved Domains (1) summary
      pfam09724
      Location:58 → 326
      Dcc1; Sister chromatid cohesion protein Dcc1

    3. XM_039078786.2 → XP_038934714.1  sister chromatid cohesion protein DCC1 isoform X1

      UniProtKB/TrEMBL
      A6HRG8
      Conserved Domains (1) summary
      pfam09724
      Location:58 → 372
      Dcc1; Sister chromatid cohesion protein Dcc1

    4. XM_039078788.2 → XP_038934716.1  sister chromatid cohesion protein DCC1 isoform X4

      Conserved Domains (1) summary
      pfam09724
      Location:58 → 208
      Dcc1; Sister chromatid cohesion protein Dcc1
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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