Adpgk ADP-dependent glucokinase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Adpgkprovided by RGD
Official Full Name: ADP-dependent glucokinaseprovided by RGD
Primary source: RGD:1306103
See related: EnsemblRapid:ENSRNOG00000026178 AllianceGenome:RGD:1306103
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1306103
Summary: Predicted to enable ADP-specific glucokinase activity. Predicted to be involved in glucose metabolic process. Predicted to be active in endoplasmic reticulum. Orthologous to human ADPGK (ADP dependent glucokinase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 134.3), Brain (RPKM 127.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q24

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (68595194..68623179)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (59699400..59727352)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (64088871..64116832)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

BI285429 (e-PCR)
- UniSTS:244780

BI296281 (e-PCR)
- UniSTS:247419

BI275024 (e-PCR)
- UniSTS:249527

RH127624 (e-PCR)
- UniSTS:210934

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ADP-specific glucokinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ADP-specific glucokinase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in glucose metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within glucose metabolic process	ISO Inferred from Sequence Orthology more info
involved_in glycolytic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ADP-dependent glucokinase

NP_001094193.1

EC 2.7.1.147

XP_006243232.1

EC 2.7.1.147

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001100723.1 → NP_001094193.1 ADP-dependent glucokinase precursor

See identical proteins and their annotated locations for NP_001094193.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

A6J519, Q5D001

Related

ENSRNOP00000013022.7, ENSRNOT00000013022.7

Conserved Domains (1) summary

cd01938
Location:60 → 492

ADPGK_ADPPFK; ADP-dependent glucokinase (ADPGK) and phosphofructokinase (ADPPFK). ADPGK and ADPPFK are proteins that rely on ADP rather than ATP to donate a phosphoryl group. They are found in certain hyperthermophilic archaea and in higher eukaryotes. A functional ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

68595194..68623179

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006243170.5 → XP_006243232.1 ADP-dependent glucokinase isoform X1

UniProtKB/TrEMBL

G3V784, Q5D001

Conserved Domains (1) summary

cd01938
Location:60 → 491

ADPGK_ADPPFK; ADP-dependent glucokinase (ADPGK) and phosphofructokinase (ADPPFK). ADPGK and ADPPFK are proteins that rely on ADP rather than ATP to donate a phosphoryl group. They are found in certain hyperthermophilic archaea and in higher eukaryotes. A functional ...