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    Col14a1 collagen type XIV alpha 1 chain [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314981, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Col14a1provided by RGD
    Official Full Name
    collagen type XIV alpha 1 chainprovided by RGD
    Primary source
    RGD:1305806
    See related
    EnsemblRapid:ENSRNOG00000026415 AllianceGenome:RGD:1305806
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to act upstream of or within several processes, including collagen fibril organization; regulation of cell growth involved in cardiac muscle cell development; and ventricular cardiac muscle tissue development. Predicted to be located in extracellular region. Predicted to be part of collagen trimer. Predicted to be active in interstitial matrix. Human ortholog(s) of this gene implicated in esophagus squamous cell carcinoma. Orthologous to human COL14A1 (collagen type XIV alpha 1 chain). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 339.8), Muscle (RPKM 238.1) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Col14a1 in Genome Data Viewer
    Location:
    7q32
    Exon count:
    49
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (88611827..88826939)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (86722093..86937215)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (95054877..95274073)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene DEP domain containing MTOR-interacting protein Neighboring gene U7 small nuclear RNA Neighboring gene ribosomal protein L31, pseudogene 5 Neighboring gene eukaryotic translation initiation factor 1, pseudogene 1 Neighboring gene mitochondrial ribosomal protein L13 Neighboring gene MDM2 binding protein Neighboring gene uncharacterized LOC120093658

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of a DNA methylome profile of esophageal squamous cell carcinoma and potential plasma epigenetic biomarkers for early diagnosis. Li X, et al. PLoS One, 2014. PMID 25050929, Free PMC Article
    2. Collagen XIV is important for growth and structural integrity of the myocardium. Tao G, et al. J Mol Cell Cardiol, 2012 Nov. PMID 22906538, Free PMC Article
    3. Proteomics characterization of extracellular space components in the human aorta. Didangelos A, et al. Mol Cell Proteomics, 2010 Sep. PMID 20551380, Free PMC Article
    4. Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins. Barallobre-Barreiro J, et al. Cardiovasc Res, 2016 Jun 1. PMID 27068509, Free PMC Article
    5. Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c. Abonnenc M, et al. Circ Res, 2013 Oct 25. PMID 24006456

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within collagen fibril organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within homeostasis of number of cells within a tissue ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of cell growth involved in cardiac muscle cell development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within ventricular cardiac muscle tissue development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of collagen trimer IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in interstitial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in interstitial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    collagen alpha-1(XIV) chain
    Names
    collagen, type XIV, alpha 1 (undulin)
    procollagen, type XIV, alpha 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130548.2 → NP_001124020.1  collagen alpha-1(XIV) chain precursor

      See identical proteins and their annotated locations for NP_001124020.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A0A8I6AK67, A6HRH1
      Related
      ENSRNOP00000093489.1, ENSRNOT00000094987.2
      Conserved Domains (7) summary
      smart00060
      Location:448 → 517
      FN3; Fibronectin type 3 domain
      smart00210
      Location:1227 → 1422
      TSPN; Thrombospondin N-terminal -like domains
      cd00063
      Location:538 → 622
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd01482
      Location:1029 → 1193
      vWA_collagen_alphaI-XII-like; Collagen: The extracellular matrix represents a complex alloy of variable members of diverse protein families defining structural integrity and various physiological functions. The most abundant family is the collagens with more than 20 different ...
      pfam00041
      Location:830 → 906
      fn3; Fibronectin type III domain
      pfam01391
      Location:1478 → 1602
      Collagen; Collagen triple helix repeat (20 copies)
      cl21522
      Location:920 → 995
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      88611827..88826939
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039079204.1 → XP_038935132.1  collagen alpha-1(XIV) chain isoform X1

      UniProtKB/TrEMBL
      A0A8I6AK67, A6HRH1
      Conserved Domains (7) summary
      smart00060
      Location:448 → 517
      FN3; Fibronectin type 3 domain
      smart00210
      Location:1227 → 1422
      TSPN; Thrombospondin N-terminal -like domains
      cd00063
      Location:538 → 622
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd01482
      Location:1029 → 1193
      vWA_collagen_alphaI-XII-like; Collagen: The extracellular matrix represents a complex alloy of variable members of diverse protein families defining structural integrity and various physiological functions. The most abundant family is the collagens with more than 20 different ...
      pfam00041
      Location:830 → 906
      fn3; Fibronectin type III domain
      pfam01391
      Location:1478 → 1602
      Collagen; Collagen triple helix repeat (20 copies)
      cl21522
      Location:920 → 995
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    2. XM_039079205.1 → XP_038935133.1  collagen alpha-1(XIV) chain isoform X2

      UniProtKB/TrEMBL
      A0A8I6AK67, D3ZZT9
      Related
      ENSRNOP00000063778.4, ENSRNOT00000067649.5
      Conserved Domains (7) summary
      smart00060
      Location:448 → 517
      FN3; Fibronectin type 3 domain
      smart00210
      Location:1227 → 1422
      TSPN; Thrombospondin N-terminal -like domains
      cd00063
      Location:538 → 622
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd01482
      Location:1029 → 1193
      vWA_collagen_alphaI-XII-like; Collagen: The extracellular matrix represents a complex alloy of variable members of diverse protein families defining structural integrity and various physiological functions. The most abundant family is the collagens with more than 20 different ...
      pfam00041
      Location:830 → 906
      fn3; Fibronectin type III domain
      pfam01391
      Location:1478 → 1602
      Collagen; Collagen triple helix repeat (20 copies)
      cl21522
      Location:920 → 995
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    Nucleotide Protein Strain
    Heading Accession and Version

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