Emg1 EMG1 N1-specific pseudouridine methyltransferase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Emg1provided by RGD
Official Full Name: EMG1 N1-specific pseudouridine methyltransferaseprovided by RGD
Primary source: RGD:1307665
See related: EnsemblRapid:ENSRNOG00000012828 AllianceGenome:RGD:1307665
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Grcc2f
Summary: Predicted to enable identical protein binding activity; rRNA (pseudouridine) methyltransferase activity; and rRNA binding activity. Predicted to be involved in rRNA base methylation and ribosomal small subunit biogenesis. Predicted to act upstream of or within blastocyst development and nucleologenesis. Predicted to be located in chromosome; nucleolus; and nucleoplasm. Predicted to be part of small-subunit processome. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Bowen-Conradi syndrome. Orthologous to human EMG1 (EMG1 N1-specific pseudouridine methyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 194.8), Heart (RPKM 160.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q42

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (159195545..159203826, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (157509258..157517540, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (157222366..157230647, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables rRNA (pseudouridine) methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables rRNA (pseudouridine) methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables rRNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within blastocyst development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within nucleologenesis	ISO Inferred from Sequence Orthology more info
involved_in rRNA base methylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in ribosomal small subunit biogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in chromosome	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of small-subunit processome	IBA Inferred from Biological aspect of Ancestor more info
part_of small-subunit processome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ribosomal RNA small subunit methyltransferase NEP1

Names: EMG1 nucleolar protein homolog; gene rich cluster, C2f; probable ribosome biogenesis protein NEP1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.