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    Rfx7 regulatory factor X, 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315804, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rfx7provided by RGD
    Official Full Name
    regulatory factor X, 7provided by RGD
    Primary source
    RGD:1308795
    See related
    EnsemblRapid:ENSRNOG00000060367 AllianceGenome:RGD:1308795
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Rfxdc2
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and RNA polymerase II core promoter sequence-specific DNA binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder. Orthologous to human RFX7 (regulatory factor X7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 143.7), Muscle (RPKM 90.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rfx7 in Genome Data Viewer
    Location:
    8q24
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (82134747..82219898)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (73254051..73339209)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (79159297..79279962)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene testis expressed 9 Neighboring gene uncharacterized LOC103693140 Neighboring gene cyclin D3, pseudogene 1 Neighboring gene NEDD4 E3 ubiquitin protein ligase Neighboring gene uncharacterized LOC100909416

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II core promoter sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    DNA-binding protein RFX7
    Names
    regulatory factor X domain containing 2 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127490.2 → NP_001120962.1  DNA-binding protein RFX7

      See identical proteins and their annotated locations for NP_001120962.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A6KEN2, E9PT49
      Related
      ENSRNOP00000069427.1, ENSRNOT00000086841.3
      Conserved Domains (1) summary
      pfam02257
      Location:105 → 181
      RFX_DNA_binding; RFX DNA-binding domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      82134747..82219898
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017595669.3 → XP_017451158.1  DNA-binding protein RFX7 isoform X1

      UniProtKB/TrEMBL
      A6KEN2, E9PT49
      Conserved Domains (1) summary
      pfam02257
      Location:105 → 181
      RFX_DNA_binding; RFX DNA-binding domain

    2. XM_006243326.5 → XP_006243388.1  DNA-binding protein RFX7 isoform X1

      See identical proteins and their annotated locations for XP_006243388.1

      UniProtKB/TrEMBL
      A6KEN2, E9PT49
      Related
      ENSRNOP00000099171.1, ENSRNOT00000141409.1
      Conserved Domains (1) summary
      pfam02257
      Location:105 → 181
      RFX_DNA_binding; RFX DNA-binding domain

    3. XM_039081516.2 → XP_038937444.1  DNA-binding protein RFX7 isoform X2

      UniProtKB/TrEMBL
      A6KEN2
      Conserved Domains (2) summary
      pfam05109
      Location:161 → 481
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam02257
      Location:8 → 84
      RFX_DNA_binding; RFX DNA-binding domain
    Nucleotide Protein Strain
    Heading Accession and Version

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