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    Msi2 musashi RNA-binding protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360596, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Msi2provided by RGD
    Official Full Name
    musashi RNA-binding protein 2provided by RGD
    Primary source
    RGD:1560397
    See related
    EnsemblRapid:ENSRNOG00000025338 AllianceGenome:RGD:1560397
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1560397
    Summary
    Predicted to enable identical protein binding activity; mRNA binding activity; and poly(U) RNA binding activity. Predicted to be involved in central nervous system development; regulation of translation; and stem cell development. Predicted to be located in cytosol and intracellular membrane-bounded organelle. Predicted to be active in cytoplasm. Orthologous to human MSI2 (musashi RNA binding protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 252.4), Muscle (RPKM 249.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Msi2 in Genome Data Viewer
    Location:
    10q26
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (73640960..74007497, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (73143760..73510566, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (75673840..76040106, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102557529 Neighboring gene coiled-coil domain containing 182 Neighboring gene uncharacterized LOC134480852 Neighboring gene uncharacterized LOC134480853 Neighboring gene uncharacterized LOC134480854 Neighboring gene uncharacterized LOC134480855 Neighboring gene A-kinase anchoring protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. RNA-binding protein Musashi family: roles for CNS stem cells and a subpopulation of ependymal cells revealed by targeted disruption and antisense ablation. Sakakibara S, et al. Proc Natl Acad Sci U S A, 2002 Nov 12. PMID 12407178, Free PMC Article
    2. Formation of Toxic Oligomeric Assemblies of RNA-binding Protein: Musashi in Alzheimer's disease. Sengupta U, et al. Acta Neuropathol Commun, 2018 Oct 26. PMID 30367664, Free PMC Article
    3. Rna-binding protein Musashi2: developmentally regulated expression in neural precursor cells and subpopulations of neurons in mammalian CNS. Sakakibara S, et al. J Neurosci, 2001 Oct 15. PMID 11588182, Free PMC Article
    4. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
    5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables poly(U) RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables single-stranded RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in central nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in stem cell development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    RNA-binding protein Musashi homolog 2; musashi RNA-binding protein 2
    Names
    Musashi homolog 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001430232.1 → NP_001417161.1  musashi RNA-binding protein 2 isoform a

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A6HHY1

    2. NM_001430233.1 → NP_001417162.1  musashi RNA-binding protein 2 isoform b

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8I6AQW7, A6HHY1

    3. NM_001430234.1 → NP_001417163.1  musashi RNA-binding protein 2 isoform c

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A6HHY1

    4. NM_001430235.1 → NP_001417164.1  musashi RNA-binding protein 2 isoform d

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A6HHY1

    5. NM_001430236.1 → NP_001417165.1  musashi RNA-binding protein 2 isoform e

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      F1LWE6

    6. NM_001430237.1 → NP_001417166.1  musashi RNA-binding protein 2 isoform f

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A6HHY1

    7. NM_001430238.1 → NP_001417167.1  musashi RNA-binding protein 2 isoform f

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A6HHY1

    8. NM_001430239.1 → NP_001417168.1  musashi RNA-binding protein 2 isoform g

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      73640960..74007497 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039087672.2 → XP_038943600.1  RNA-binding protein Musashi homolog 2 isoform X11

      Conserved Domains (2) summary
      cd12323
      Location:111 → 184
      RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
      cd12760
      Location:17 → 109
      RRM1_MSI2; RNA recognition motif 1 (RRM1) found in RNA-binding protein Musashi homolog 2 (Musashi-2 ) and similar proteins

    2. XM_039087667.2 → XP_038943595.1  RNA-binding protein Musashi homolog 2 isoform X6

      Conserved Domains (2) summary
      cd12323
      Location:111 → 184
      RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
      cd12760
      Location:17 → 109
      RRM1_MSI2; RNA recognition motif 1 (RRM1) found in RNA-binding protein Musashi homolog 2 (Musashi-2 ) and similar proteins

    3. XM_039087663.2 → XP_038943591.1  RNA-binding protein Musashi homolog 2 isoform X3

      Related
      ENSRNOP00000096507.1, ENSRNOT00000099554.2
      Conserved Domains (2) summary
      cd12323
      Location:111 → 184
      RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
      cd12760
      Location:17 → 109
      RRM1_MSI2; RNA recognition motif 1 (RRM1) found in RNA-binding protein Musashi homolog 2 (Musashi-2 ) and similar proteins

    4. XM_039087669.2 → XP_038943597.1  RNA-binding protein Musashi homolog 2 isoform X10

      Conserved Domains (2) summary
      cd12323
      Location:111 → 184
      RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
      cd12760
      Location:17 → 109
      RRM1_MSI2; RNA recognition motif 1 (RRM1) found in RNA-binding protein Musashi homolog 2 (Musashi-2 ) and similar proteins

    5. XM_039087661.2 → XP_038943589.1  RNA-binding protein Musashi homolog 2 isoform X2

      Conserved Domains (3) summary
      TIGR01628
      Location:35 → 339
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12323
      Location:111 → 184
      RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
      cd12760
      Location:17 → 109
      RRM1_MSI2; RNA recognition motif 1 (RRM1) found in RNA-binding protein Musashi homolog 2 (Musashi-2 ) and similar proteins

    6. XM_063270136.1 → XP_063126206.1  RNA-binding protein Musashi homolog 2 isoform X7

      UniProtKB/TrEMBL
      A6HHY1

    7. XM_063270135.1 → XP_063126205.1  RNA-binding protein Musashi homolog 2 isoform X4

      UniProtKB/TrEMBL
      A6HHY1
      Related
      ENSRNOP00000090730.2, ENSRNOT00000106986.2

    8. XM_039087664.2 → XP_038943592.1  RNA-binding protein Musashi homolog 2 isoform X5

      UniProtKB/TrEMBL
      A6HHY1
      Conserved Domains (3) summary
      TIGR01628
      Location:35 → 333
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12323
      Location:111 → 184
      RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
      cd12760
      Location:17 → 109
      RRM1_MSI2; RNA recognition motif 1 (RRM1) found in RNA-binding protein Musashi homolog 2 (Musashi-2 ) and similar proteins

    9. XM_063270134.1 → XP_063126204.1  RNA-binding protein Musashi homolog 2 isoform X1

      UniProtKB/TrEMBL
      A6HHY1
      Related
      ENSRNOP00000087497.2, ENSRNOT00000112171.2

    10. XM_017597690.3 → XP_017453179.1  RNA-binding protein Musashi homolog 2 isoform X13

      UniProtKB/TrEMBL
      A0A8I6AAP6

    11. XM_039087674.2 → XP_038943602.1  RNA-binding protein Musashi homolog 2 isoform X12

      Conserved Domains (2) summary
      TIGR01628
      Location:60 → 275
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cl17169
      Location:59 → 108
      RRM_SF; RNA recognition motif (RRM) superfamily

    12. XM_039087676.2 → XP_038943604.1  RNA-binding protein Musashi homolog 2 isoform X14

      UniProtKB/TrEMBL
      A0A8I6AAP6
      Conserved Domains (2) summary
      TIGR01628
      Location:2 → 212
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cl17169
      Location:1 → 45
      RRM_SF; RNA recognition motif (RRM) superfamily

    13. XM_063270138.1 → XP_063126208.1  RNA-binding protein Musashi homolog 2 isoform X9

    14. XM_063270137.1 → XP_063126207.1  RNA-binding protein Musashi homolog 2 isoform X8

      UniProtKB/TrEMBL
      A0A8I6GG20
      Related
      ENSRNOP00000107092.1, ENSRNOT00000153490.1
    Nucleotide Protein Strain
    Heading Accession and Version

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