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    Gpr155 G protein-coupled receptor 155 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311730, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gpr155provided by RGD
    Official Full Name
    G protein-coupled receptor 155provided by RGD
    Primary source
    RGD:1309162
    See related
    EnsemblRapid:ENSRNOG00000018485 AllianceGenome:RGD:1309162
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable cholesterol binding activity. Predicted to be involved in several processes, including cellular response to amino acid starvation; cellular response to cholesterol; and regulation of signal transduction. Predicted to be active in lysosomal membrane. Orthologous to human GPR155 (G protein-coupled receptor 155). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 90.4), Muscle (RPKM 51.5) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gpr155 in Genome Data Viewer
    Location:
    3q23
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (78623931..78677803, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (58216422..58270350, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (60051545..60105567, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene corepressor interacting with RBPJ, 1 Neighboring gene secernin 3 Neighboring gene uncharacterized LOC134486289 Neighboring gene WAS/WASL interacting protein family, member 1 Neighboring gene uncharacterized LOC134486113

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Genome-wide expression profiling of lymphoblastoid cell lines distinguishes different forms of autism and reveals shared pathways. Nishimura Y, et al. Hum Mol Genet, 2007 Jul 15. PMID 17519220
    2. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article
    3. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cholesterol binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to amino acid starvation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to cholesterol ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cognition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of BMP signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of TORC1 signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    lysosomal cholesterol signaling protein
    Names
    integral membrane protein GPR155

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107811.1 → NP_001101281.1  lysosomal cholesterol signaling protein

      See identical proteins and their annotated locations for NP_001101281.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473949
      UniProtKB/TrEMBL
      A0A0G2JZP1, A6HM90, D3ZWM3
      Related
      ENSRNOP00000025158.4, ENSRNOT00000025158.7
      Conserved Domains (3) summary
      cd04443
      Location:749 → 831
      DEP_GPR155; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in GPR155-like proteins. GRP155-like proteins, also known as PGR22, contain an N-terminal permease domain, a central transmembrane region and a C-terminal DEP domain. They are orphan receptors of the ...
      cl21561
      Location:387 → 507
      7tm_4; Olfactory receptor
      cl22894
      Location:36 → 364
      Mem_trans; Membrane transport protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      78623931..78677803 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006234356.5 → XP_006234418.1  lysosomal cholesterol signaling protein isoform X2

      UniProtKB/TrEMBL
      A6HM92
      Conserved Domains (3) summary
      cl02442
      Location:749 → 776
      DEP; DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is ...
      cl21561
      Location:387 → 507
      7tm_4; Olfactory receptor
      cl22894
      Location:36 → 364
      Mem_trans; Membrane transport protein

    2. XM_039105161.2 → XP_038961089.1  lysosomal cholesterol signaling protein isoform X1

      UniProtKB/TrEMBL
      A6HM92
      Conserved Domains (4) summary
      cl22894
      Location:36 → 364
      Mem_trans; Membrane transport protein
      cd14964
      Location:410 → 432
      7tm_GPCRs; TM helix 2 [structural motif]
      cl02442
      Location:749 → 773
      DEP; DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is ...
      cl28897
      Location:385 → 507
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    3. XM_006234357.5 → XP_006234419.1  lysosomal cholesterol signaling protein isoform X3

      See identical proteins and their annotated locations for XP_006234419.1

      UniProtKB/TrEMBL
      A6HM91, A6HM92
      Conserved Domains (3) summary
      cl02442
      Location:749 → 777
      DEP; DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is ...
      cl21561
      Location:387 → 507
      7tm_4; Olfactory receptor
      cl22894
      Location:36 → 364
      Mem_trans; Membrane transport protein
    Nucleotide Protein Strain
    Heading Accession and Version

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