Adam10 ADAM metallopeptidase domain 10 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Adam10provided by RGD
Full Name: ADAM metallopeptidase domain 10provided by RGD
Primary source: RGD:2032
See related: EnsemblRapid:ENSRNOG00000054257 AllianceGenome:RGD:2032
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: MADM
Summary: Enables metalloendopeptidase activity. Involved in several processes, including amyloid-beta formation; regulation of dendritic spine morphogenesis; and response to antineoplastic agent. Located in several cellular components, including postsynaptic membrane; synaptic vesicle; and trans-Golgi network. Is active in glutamatergic synapse and postsynapse. Biomarker of several diseases, including Alzheimer's disease; cataract; status epilepticus; thoracic aortic aneurysm; and traumatic brain injury. Human ortholog(s) of this gene implicated in Alzheimer's disease 18 and reticulate acropigmentation of Kitamura. Orthologous to human ADAM10 (ADAM metallopeptidase domain 10). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 367.5), Thymus (RPKM 291.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q24

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (80226862..80358728)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (71346008..71477889)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (77107355..77237483)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Extracellular-Signal-Regulated Kinase Inhibition Switches APP Processing from beta- to alpha-Secretase under Oxidative Stress: Modulation of ADAM10 by SIRT1/NF-kappaB Signaling.
Title: Extracellular-Signal-Regulated Kinase Inhibition Switches APP Processing from β- to α-Secretase under Oxidative Stress: Modulation of ADAM10 by SIRT1/NF-κB Signaling.
Abeta1-42 oligomers trigger an aberrant plasticity mechanism according to which Abeta1-42 oligomers can downregulate Abeta generation through the modulation of ADAM10 synaptic availability.
Title: Amyloid-β Oligomers Regulate ADAM10 Synaptic Localization Through Aberrant Plasticity Phenomena.
This study demonstrates the involvement of ADAM10 and PI3K/Akt signaling in mediating RLX-induced Notch-1 activation.
Title: Relaxin induces up-regulation of ADAM10 metalloprotease in RXFP1-expressing cells by PI3K/AKT signaling.
our results indicate a positive role of PLD1 in synaptogenesis by inhibiting the ADAM10 mediated N-cadherin cleavage and provide new therapeutic clues for some neurological diseases.
Title: PLD1 promotes dendritic spine development by inhibiting ADAM10-mediated N-cadherin cleavage.
In this study, we demonstrated that ADAM10 plays an important role in PAX2-induced EMT in the renal tubular epithelia
Title: PAX2 may induce ADAM10 expression in renal tubular epithelial cells and contribute to epithelial-to-mesenchymal transition.
Our findings indicate that neuron-derived ADAM10 production stimulates peripheral nerve injury-induced neuropathic pain by cleaving E-cadherin in satellite glial cells.
Title: Neuron-Derived ADAM10 Production Stimulates Peripheral Nerve Injury-Induced Neuropathic Pain by Cleavage of E-Cadherin in Satellite Glial Cells.
These results demonstrated the localization of VDR on the neuronal plasma membrane and the co-localization of VDR and APP or ADAM10 or Nicastrin and limited co-localization of VDR and PS1.
Title: Vitamin D receptor is present on the neuronal plasma membrane and is co-localized with amyloid precursor protein, ADAM10 or Nicastrin.
TGF-beta stimulation of renal cells results in a significant up-regulation of Adams 10, 17, 12, and 19
Title: Canonical transforming growth factor-β signaling regulates disintegrin metalloprotease expression in experimental renal fibrosis via miR-29.
Time- and injury-dependent expression of MT5-MMP, ADAM-10, and N-cadherin are confirmed during reactive synaptogenesis.
Title: MT5-MMP, ADAM-10, and N-cadherin act in concert to facilitate synapse reorganization after traumatic brain injury.
PACAP38 is involved in the modulation of dendritic spine morphology in hippocampal neurons; the ADAM10-N-cadherin signaling pathway plays a crucial role in this modification of the excitatory glutamatergic synapse.
Title: The neuropeptide PACAP38 induces dendritic spine remodeling through ADAM10-N-cadherin signaling pathway.

Submit: New GeneRIF Correction See all GeneRIFs (17)

General gene information

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Markers

Adam10 (e-PCR), detects polymorphism
- UniSTS:471063

RH17532 (e-PCR)
- UniSTS:65890

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables SH3 domain binding	IEA Inferred from Electronic Annotation more info
enables endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metallodipeptidase activity	IEA Inferred from Electronic Annotation more info
enables metallodipeptidase activity	ISO Inferred from Sequence Orthology more info
enables metalloendopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	ISO Inferred from Sequence Orthology more info
enables metalloendopeptidase activity involved in amyloid precursor protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
enables metalloendopeptidase activity involved in amyloid precursor protein catabolic process	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity involved in amyloid precursor protein catabolic process	ISO Inferred from Sequence Orthology more info
enables metallopeptidase activity	ISO Inferred from Sequence Orthology more info
enables metallopeptidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in Notch signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in Notch signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in Notch signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in Notch signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in adherens junction organization	IEA Inferred from Electronic Annotation more info
involved_in adherens junction organization	ISO Inferred from Sequence Orthology more info
involved_in amyloid precursor protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in amyloid precursor protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in amyloid-beta formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cochlea development	IEA Inferred from Electronic Annotation more info
involved_in cochlea development	ISO Inferred from Sequence Orthology more info
involved_in constitutive protein ectodomain proteolysis	IEA Inferred from Electronic Annotation more info
involved_in constitutive protein ectodomain proteolysis	ISO Inferred from Sequence Orthology more info
involved_in epidermal growth factor receptor ligand maturation	IEA Inferred from Electronic Annotation more info
involved_in epidermal growth factor receptor ligand maturation	ISO Inferred from Sequence Orthology more info
involved_in in utero embryonic development	IEA Inferred from Electronic Annotation more info
involved_in in utero embryonic development	ISO Inferred from Sequence Orthology more info
involved_in in utero embryonic development	ISS Inferred from Sequence or Structural Similarity more info
involved_in membrane protein ectodomain proteolysis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within membrane protein ectodomain proteolysis	ISO Inferred from Sequence Orthology more info
involved_in membrane protein ectodomain proteolysis	ISO Inferred from Sequence Orthology more info
involved_in membrane protein ectodomain proteolysis	ISS Inferred from Sequence or Structural Similarity more info
involved_in monocyte activation	IEA Inferred from Electronic Annotation more info
involved_in monocyte activation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell adhesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of gene expression	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in pore complex assembly	IEA Inferred from Electronic Annotation more info
involved_in pore complex assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of T cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell growth	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in postsynapse organization	IEA Inferred from Electronic Annotation more info
involved_in postsynapse organization	ISO Inferred from Sequence Orthology more info
involved_in protein catabolic process at postsynapse	IEA Inferred from Electronic Annotation more info
involved_in protein catabolic process at postsynapse	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein processing	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in regulation of Notch signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in regulation of Notch signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of cellular component organization	IEA Inferred from Electronic Annotation more info
involved_in regulation of dendritic spine morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	IEA Inferred from Electronic Annotation more info
involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	ISO Inferred from Sequence Orthology more info
involved_in regulation of osteoclast differentiation	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of postsynapse organization	IEA Inferred from Electronic Annotation more info
involved_in regulation of postsynapse organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of vasculature development	IEA Inferred from Electronic Annotation more info
involved_in regulation of vasculature development	ISO Inferred from Sequence Orthology more info
involved_in response to antineoplastic agent	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to tumor necrosis factor	IEA Inferred from Electronic Annotation more info
involved_in response to tumor necrosis factor	ISO Inferred from Sequence Orthology more info
involved_in signaling receptor ligand precursor processing	ISO Inferred from Sequence Orthology more info
involved_in spermatogenesis	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in Golgi-associated vesicle	IEA Inferred from Electronic Annotation more info
located_in Golgi-associated vesicle	ISO Inferred from Sequence Orthology more info
located_in Golgi-associated vesicle	ISS Inferred from Sequence or Structural Similarity more info
located_in adherens junction	IEA Inferred from Electronic Annotation more info
located_in axon	IEA Inferred from Electronic Annotation more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISS Inferred from Sequence or Structural Similarity more info
located_in clathrin-coated vesicle	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic spine	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in perinuclear endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in perinuclear endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of pore complex	IEA Inferred from Electronic Annotation more info
part_of pore complex	ISO Inferred from Sequence Orthology more info
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
located_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic density	IEA Inferred from Electronic Annotation more info
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info
located_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in synaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in synaptic membrane	IEA Inferred from Electronic Annotation more info
located_in synaptic membrane	ISO Inferred from Sequence Orthology more info
located_in synaptic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in tetraspanin-enriched microdomain	IEA Inferred from Electronic Annotation more info
located_in tetraspanin-enriched microdomain	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: disintegrin and metalloproteinase domain-containing protein 10

Names: ADAM 10; RGD1566370; a disintegrin and metallopeptidase domain 10; a disintegrin and metalloprotease domain 10; kuzbanian protein homolog; mammalian disintegrin-metalloprotease

NP_062127.1

EC 3.4.24.81

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019254.1 → NP_062127.1 disintegrin and metalloproteinase domain-containing protein 10 precursor

See identical proteins and their annotated locations for NP_062127.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/Swiss-Prot

A0A0G2K562, Q10743

UniProtKB/TrEMBL

A0A8I5ZQN5

Related

ENSRNOP00000109148.1, ENSRNOT00000159997.1

Conserved Domains (3) summary

smart00050
Location:467 → 546

DISIN; Homologues of snake disintegrins

cd04270
Location:221 → 460

ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.

pfam01562
Location:48 → 141

Pep_M12B_propep; Reprolysin family propeptide