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    Iqsec1 IQ motif and Sec7 domain ArfGEF 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 686590, updated on 9-Dec-2024

    Summary

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    Symbol
    Iqsec1provided by RGD
    Full Name
    IQ motif and Sec7 domain ArfGEF 1provided by RGD
    Primary source
    RGD:1596313
    See related
    EnsemblRapid:ENSRNOG00000060350 AllianceGenome:RGD:1596313
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein kinase binding activity. Involved in positive regulation of synapse assembly; regulation of ARF protein signal transduction; and regulation of postsynaptic neurotransmitter receptor internalization. Predicted to be located in nucleolus. Predicted to be active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic density, intracellular component. Human ortholog(s) of this gene implicated in intellectual developmental disorder with short stature and behavioral abnormalities and lung adenocarcinoma. Orthologous to human IQSEC1 (IQ motif and Sec7 domain ArfGEF 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 143.5), Brain (RPKM 141.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Iqsec1 in Genome Data Viewer
    Location:
    4q34
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (124725917..125045351, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (123168719..123488300, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (123400717..123454656)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene aldehyde dehydrogenase 1 family, member L1 Neighboring gene uncharacterized LOC134486815 Neighboring gene solute carrier family 41, member 3 Neighboring gene uncharacterized LOC134486814 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene nucleoporin 210 Neighboring gene uncharacterized LOC134486816 Neighboring gene histone deacetylase 11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Down-regulation of GEP100 causes increase in E-cadherin levels and inhibits pancreatic cancer cell invasion. Xie CG, et al. PLoS One, 2012. PMID 22662237, Free PMC Article
    2. Distinct synaptic localization patterns of brefeldin A-resistant guanine nucleotide exchange factors BRAG2 and BRAG3 in the mouse retina. Sakagami H, et al. J Comp Neurol, 2013 Mar 1. PMID 22886754
    3. Engagement of overexpressed Her2 with GEP100 induces autonomous invasive activities and provides a biomarker for metastases of lung adenocarcinoma. Menju T, et al. PLoS One, 2011. PMID 21966491, Free PMC Article
    4. Epidermal growth factor receptor-GEP100-Arf6 axis affects the prognosis of lung adenocarcinoma. Oka S, et al. Oncology, 2014. PMID 24902879
    5. Genetic and epigenetic analysis of non-small cell lung cancer with NotI-microarrays. Dmitriev AA, et al. Epigenetics, 2012 May. PMID 22491060

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. both Arf6 activation through GluN2B-BRAG1 during early development and the transition from BRAG1- to BRAG2-dependent Arf6 signaling induced by the GluN2 subunit switch are critical for the development of mature glutamatergic synapses.
      Title: Subunit-selective N-Methyl-d-aspartate (NMDA) Receptor Signaling through Brefeldin A-resistant Arf Guanine Nucleotide Exchange Factors BRAG1 and BRAG2 during Synapse Maturation.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in dendritic spine development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of focal adhesion disassembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of keratinocyte migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of synapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in postsynaptic modulation of chemical synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of ARF protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of ARF protein signal transduction IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of postsynaptic neurotransmitter receptor internalization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of postsynaptic neurotransmitter receptor internalization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Schaffer collateral - CA1 synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in postsynaptic density, intracellular component ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synaptic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    IQ motif and SEC7 domain-containing protein 1
    Names
    IQ motif and Sec7 domain 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001408959.1 → NP_001395888.1  IQ motif and SEC7 domain-containing protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A8I5ZSW3
      Related
      ENSRNOP00000081495.2, ENSRNOT00000098236.2

    2. NM_001408960.1 → NP_001395889.1  IQ motif and SEC7 domain-containing protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/Swiss-Prot
      A0A0G2JUG7
      UniProtKB/TrEMBL
      A0A8I6G7L1
      Related
      ENSRNOP00000081156.1, ENSRNOT00000113793.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      124725917..125045351 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039108750.2 → XP_038964678.1  IQ motif and SEC7 domain-containing protein 1 isoform X3

      Conserved Domains (2) summary
      pfam01369
      Location:587 → 775
      Sec7; Sec7 domain
      pfam16453
      Location:807 → 942
      IQ_SEC7_PH; PH domain

    2. XM_039108749.2 → XP_038964677.1  IQ motif and SEC7 domain-containing protein 1 isoform X2

      Conserved Domains (2) summary
      pfam01369
      Location:597 → 785
      Sec7; Sec7 domain
      pfam16453
      Location:817 → 952
      IQ_SEC7_PH; PH domain

    3. XM_039108758.2 → XP_038964686.1  IQ motif and SEC7 domain-containing protein 1 isoform X8

      UniProtKB/TrEMBL
      A0A8L2R061
      Conserved Domains (2) summary
      pfam01369
      Location:612 → 800
      Sec7; Sec7 domain
      pfam16453
      Location:832 → 967
      IQ_SEC7_PH; PH domain

    4. XM_039108760.2 → XP_038964688.1  IQ motif and SEC7 domain-containing protein 1 isoform X10

      UniProtKB/TrEMBL
      A0A8L2R061
      Conserved Domains (2) summary
      pfam01369
      Location:612 → 800
      Sec7; Sec7 domain
      pfam16453
      Location:832 → 967
      IQ_SEC7_PH; PH domain

    5. XM_039108759.2 → XP_038964687.1  IQ motif and SEC7 domain-containing protein 1 isoform X9

      UniProtKB/Swiss-Prot
      A0A0G2JUG7
      UniProtKB/TrEMBL
      A0A8I6ANF6
      Conserved Domains (2) summary
      pfam01369
      Location:612 → 800
      Sec7; Sec7 domain
      pfam16453
      Location:832 → 967
      IQ_SEC7_PH; PH domain

    6. XM_039108748.2 → XP_038964676.1  IQ motif and SEC7 domain-containing protein 1 isoform X1

      Related
      ENSRNOP00000111646.1, ENSRNOT00000152016.1
      Conserved Domains (2) summary
      pfam01369
      Location:612 → 800
      Sec7; Sec7 domain
      pfam16453
      Location:832 → 967
      IQ_SEC7_PH; PH domain

    7. XM_039108756.2 → XP_038964684.1  IQ motif and SEC7 domain-containing protein 1 isoform X7

      UniProtKB/Swiss-Prot
      A0A0G2JUG7
      Related
      ENSRNOP00000107769.1, ENSRNOT00000150411.1
      Conserved Domains (2) summary
      pfam01369
      Location:521 → 709
      Sec7; Sec7 domain
      pfam16453
      Location:741 → 876
      IQ_SEC7_PH; PH domain

    8. XM_063286695.1 → XP_063142765.1  IQ motif and SEC7 domain-containing protein 1 isoform X14

      UniProtKB/Swiss-Prot
      A0A0G2JUG7

    9. XM_039108754.2 → XP_038964682.1  IQ motif and SEC7 domain-containing protein 1 isoform X6

      UniProtKB/Swiss-Prot
      A0A0G2JUG7
      Conserved Domains (2) summary
      pfam01369
      Location:523 → 711
      Sec7; Sec7 domain
      pfam16453
      Location:743 → 878
      IQ_SEC7_PH; PH domain

    10. XM_039108753.2 → XP_038964681.1  IQ motif and SEC7 domain-containing protein 1 isoform X5

      UniProtKB/Swiss-Prot
      A0A0G2JUG7
      Related
      ENSRNOP00000077923.2, ENSRNOT00000105189.2
      Conserved Domains (2) summary
      pfam01369
      Location:526 → 714
      Sec7; Sec7 domain
      pfam16453
      Location:746 → 881
      IQ_SEC7_PH; PH domain

    11. XM_063286694.1 → XP_063142764.1  IQ motif and SEC7 domain-containing protein 1 isoform X13

      UniProtKB/Swiss-Prot
      A0A0G2JUG7

    12. XM_039108762.2 → XP_038964690.1  IQ motif and SEC7 domain-containing protein 1 isoform X16

      UniProtKB/TrEMBL
      A6IB89
      Conserved Domains (3) summary
      PHA03307
      Location:89 → 306
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam01369
      Location:401 → 589
      Sec7; Sec7 domain
      pfam16453
      Location:621 → 756
      IQ_SEC7_PH; PH domain

    13. XM_063286693.1 → XP_063142763.1  IQ motif and SEC7 domain-containing protein 1 isoform X11

      UniProtKB/TrEMBL
      A0A8I5YC35
      Related
      ENSRNOP00000095381.2, ENSRNOT00000104320.2

    14. XM_063286696.1 → XP_063142766.1  IQ motif and SEC7 domain-containing protein 1 isoform X15

      UniProtKB/TrEMBL
      A0A8I5YC35, A0A8I6GBT6

    15. XM_006236890.5 → XP_006236952.1  IQ motif and SEC7 domain-containing protein 1 isoform X12

      UniProtKB/Swiss-Prot
      A0A0G2JUG7
      Conserved Domains (3) summary
      PHA03307
      Location:210 → 427
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam01369
      Location:522 → 710
      Sec7; Sec7 domain
      pfam16453
      Location:742 → 872
      IQ_SEC7_PH; PH domain

    16. XM_039108751.2 → XP_038964679.1  IQ motif and SEC7 domain-containing protein 1 isoform X4

      UniProtKB/TrEMBL
      A0A8I5YC35
      Related
      ENSRNOP00000085130.2, ENSRNOT00000114697.2
      Conserved Domains (2) summary
      pfam01369
      Location:522 → 710
      Sec7; Sec7 domain
      pfam16453
      Location:742 → 877
      IQ_SEC7_PH; PH domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0G2JUG7.1 GenPept UniProtKB/Swiss-Prot:A0A0G2JUG7

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