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    Phka1 phosphorylase kinase regulatory subunit alpha 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64561, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Phka1provided by RGD
    Official Full Name
    phosphorylase kinase regulatory subunit alpha 1provided by RGD
    Primary source
    RGD:621522
    See related
    EnsemblRapid:ENSRNOG00000003063 AllianceGenome:RGD:621522
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Pcyt1b
    Summary
    Predicted to enable choline-phosphate cytidylyltransferase activity. Involved in protein autophosphorylation. Part of phosphorylase kinase complex. Used to study hypothyroidism. Human ortholog(s) of this gene implicated in glycogen storage disease and glycogen storage disease IXd. Orthologous to human PHKA1 (phosphorylase kinase regulatory subunit alpha 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 1002.7), Heart (RPKM 88.4) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Phka1 in Genome Data Viewer
    Location:
    Xq22
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (71639701..71778465, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (67601302..67738504, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (72377020..72515385, complement)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1 Neighboring gene histone deacetylase 8 Neighboring gene ribosomal protein S27a, pseudogene 3 Neighboring gene kelch domain containing 2 like 1 Neighboring gene NSA2 ribosome biogenesis factor, pseudogene 16 Neighboring gene DMRT-like family C1a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Baculovirus-mediated overexpression of the phosphorylase b kinase holoenzyme and alpha gamma delta and gamma delta subcomplexes. Kumar P, et al. Biochemistry, 2004 Aug 10. PMID 15287752
    2. Phosphorylase a formation in protein-glycogen particles isolated from fast-twitch muscle of euthyroid and hypothyroid rats. Leijendekker WJ, et al. Arch Biochem Biophys, 1989 Oct. PMID 2774570
    3. Both acidic and basic amino acids in an amphitropic enzyme, CTP:phosphocholine cytidylyltransferase, dictate its selectivity for anionic membranes. Johnson JE, et al. J Biol Chem, 2003 Jan 3. PMID 12401806
    4. The content of glycogen phosphorylase and glycogen in preparations of sarcoplasmic reticulum-glycogenolytic complex is enhanced in diabetic rat skeletal muscle. Garduño E, et al. Diabetologia, 2001 Oct. PMID 11692172
    5. cDNA cloning and complete primary structure of skeletal muscle phosphorylase kinase (alpha subunit). Zander NF, et al. Proc Natl Acad Sci U S A, 1988 May. PMID 3362857, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables choline-phosphate cytidylyltransferase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in CDP-choline pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycogen metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidylcholine biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of glycogen catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of phosphorylase kinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of phosphorylase kinase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform
    Names
    PhK-alpha-subunit
    phosphorylase B kinase alpha subunit
    phosphorylase kinase alpha M subunit
    phosphorylase kinase alpha-subunit
    phosphorylase kinase, alpha 1
    NP_072148.2
    XP_006257164.1
    XP_063136353.1
    XP_063136354.1
    XP_063136355.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022626.2 → NP_072148.2  phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/Swiss-Prot
      Q64649, Q64650, Q64651, Q9QZ77
      UniProtKB/TrEMBL
      A0A096MJF7
      Related
      ENSRNOP00000068112.1, ENSRNOT00000076850.4
      Conserved Domains (3) summary
      pfam00723
      Location:8 → 439
      Glyco_hydro_15; Glycosyl hydrolases family 15
      pfam19292
      Location:1078 → 1152
      KPBB_C; Phosphorylase b kinase C-terminal domain
      cl42434
      Location:806 → 923
      Glyco_hydro_15; Glycosyl hydrolases family 15

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      71639701..71778465 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006257102.5 → XP_006257164.1  phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X3

      UniProtKB/Swiss-Prot
      Q64649, Q64650, Q64651, Q9QZ77
      UniProtKB/TrEMBL
      A0A096MJV9
      Related
      ENSRNOP00000068281.1, ENSRNOT00000076725.4
      Conserved Domains (1) summary
      pfam00723
      Location:8 → 439
      Glyco_hydro_15; Glycosyl hydrolases family 15

    2. XM_063280283.1 → XP_063136353.1  phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X1

      UniProtKB/TrEMBL
      A0A8I6A560, F1LLZ7
      Related
      ENSRNOP00000085979.1, ENSRNOT00000075929.3

    3. XM_063280285.1 → XP_063136355.1  phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X4

      UniProtKB/TrEMBL
      F1LLZ7

    4. XM_063280284.1 → XP_063136354.1  phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X2

      UniProtKB/TrEMBL
      F1LLZ7
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q64649.2 GenPept UniProtKB/Swiss-Prot:Q64649

    Gene LinkOut

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