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    Syap1 synapse associated protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 302678, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Syap1provided by RGD
    Official Full Name
    synapse associated protein 1provided by RGD
    Primary source
    RGD:1303113
    See related
    EnsemblRapid:ENSRNOG00000004304 AllianceGenome:RGD:1303113
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in several processes, including TORC2 signaling; cellular response to epidermal growth factor stimulus; and cellular response to peptide hormone stimulus. Predicted to be located in several cellular components, including cytoplasmic side of plasma membrane; perikaryon; and synaptic membrane. Predicted to be active in Golgi apparatus; nucleus; and synapse. Orthologous to human SYAP1 (synapse associated protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 268.4), Adrenal (RPKM 187.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Syap1 in Genome Data Viewer
    Location:
    Xq14
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (35423947..35458472)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (31792180..31826672)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (33528071..33562584)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene CTP synthase 2 Neighboring gene S100 calcium binding protein G Neighboring gene ornithine decarboxylase 1, pseudogene 2 Neighboring gene U6 spliceosomal RNA Neighboring gene heterogeneous nuclear ribonucleoprotein D, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Initial characterization of a Syap1 knock-out mouse and distribution of Syap1 in mouse brain and cultured motoneurons. Schmitt D, et al. Histochem Cell Biol, 2016 Oct. PMID 27344443, Free PMC Article
    2. BSTA promotes mTORC2-mediated phosphorylation of Akt1 to suppress expression of FoxC2 and stimulate adipocyte differentiation. Yao Y, et al. Sci Signal, 2013 Jan 8. PMID 23300339, Free PMC Article
    3. Large-scale identification of mammalian proteins localized to nuclear sub-compartments. Sutherland HG, et al. Hum Mol Genet, 2001 Sep 1. PMID 11555636
    4. Proteomic analysis of exosomes from human neural stem cells by flow field-flow fractionation and nanoflow liquid chromatography-tandem mass spectrometry. Kang D, et al. J Proteome Res, 2008 Aug. PMID 18570454
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94115

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in TORC2 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in TORC2 signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to epidermal growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to insulin stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to insulin-like growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to platelet-derived growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of short-term neuronal synaptic plasticity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in growth cone ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perikaryon ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in presynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    synapse-associated protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395553.1 → NP_001382482.1  synapse-associated protein 1

      Status: VALIDATED

      Source sequence(s)
      FM069627, FN805488, JAXUCZ010000021
      UniProtKB/TrEMBL
      A6K2N4, F7F350, Q6AYB6
      Related
      ENSRNOP00000006584.5, ENSRNOT00000006584.8
      Conserved Domains (1) summary
      smart00751
      Location:169 → 219
      BSD; domain in transcription factors and synapse-associated proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      35423947..35458472
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039099662.2 → XP_038955590.1  synapse-associated protein 1 isoform X1

      Conserved Domains (1) summary
      smart00751
      Location:169 → 219
      BSD; domain in transcription factors and synapse-associated proteins

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001004253.1: Suppressed sequence

      Description
      NM_001004253.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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