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    Wwp1 WW domain containing E3 ubiquitin protein ligase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 297930, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Wwp1provided by RGD
    Official Full Name
    WW domain containing E3 ubiquitin protein ligase 1provided by RGD
    Primary source
    RGD:1311734
    See related
    EnsemblRapid:ENSRNOG00000006328 AllianceGenome:RGD:1311734
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in negative regulation of DNA-templated transcription; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein ubiquitination. Predicted to be active in cytoplasm. Orthologous to human WWP1 (WW domain containing E3 ubiquitin protein ligase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 379.1), Muscle (RPKM 358.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Wwp1 in Genome Data Viewer
    Location:
    5q13
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (37889280..37982743, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (33092379..33185887, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (33608489..33696487, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene cyclic nucleotide gated channel subunit beta 3 Neighboring gene high mobility group protein B1-like Neighboring gene copine 3 Neighboring gene regulator of microtubule dynamics 1 Neighboring gene uncharacterized LOC134478942 Neighboring gene PYM homolog 1, exon junction complex associated factor, pseudogene 15 Neighboring gene 60S ribosomal protein L13 pseudogene Neighboring gene solute carrier family 7 member 13

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. WW domain containing E3 ubiquitin protein ligase 1 targets the full-length ErbB4 for ubiquitin-mediated degradation in breast cancer. Li Y, et al. Oncogene, 2009 Aug 20. PMID 19561640
    2. The Nedd4-like family of E3 ubiquitin ligases and cancer. Chen C, et al. Cancer Metastasis Rev, 2007 Dec. PMID 17726579
    3. The E3 ubiquitin ligase WWP1 selectively targets HER4 and its proteolytically derived signaling isoforms for degradation. Feng SM, et al. Mol Cell Biol, 2009 Feb. PMID 19047365, Free PMC Article
    4. Regulation of adult bone mass by the zinc finger adapter protein Schnurri-3. Jones DC, et al. Science, 2006 May 26. PMID 16728642
    5. Lung Krüppel-like factor contains an autoinhibitory domain that regulates its transcriptional activation by binding WWP1, an E3 ubiquitin ligase. Conkright MD, et al. J Biol Chem, 2001 Aug 3. PMID 11375995

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    NEDD4-like E3 ubiquitin-protein ligase WWP1
    NP_001019928.1
    XP_006237992.1
    XP_006237993.1
    XP_008761813.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024757.1 → NP_001019928.1  NEDD4-like E3 ubiquitin-protein ligase WWP1

      See identical proteins and their annotated locations for NP_001019928.1

      Status: PROVISIONAL

      Source sequence(s)
      BC097386
      UniProtKB/TrEMBL
      Q4V8H7
      Conserved Domains (6) summary
      cd04021
      Location:17 → 140
      C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
      smart00119
      Location:587 → 915
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:564 → 916
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd00201
      Location:495 → 524
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      pfam00397
      Location:347 → 376
      WW; WW domain
      pfam17061
      Location:193 → 350
      PARM; PARM

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      37889280..37982743 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006237930.5 → XP_006237992.1  NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X1

      See identical proteins and their annotated locations for XP_006237992.1

      UniProtKB/TrEMBL
      F7FIK1
      Related
      ENSRNOP00000009047.6, ENSRNOT00000009047.7
      Conserved Domains (6) summary
      cd04021
      Location:67 → 190
      C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
      smart00119
      Location:637 → 965
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:614 → 966
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd00201
      Location:545 → 574
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      pfam00397
      Location:397 → 426
      WW; WW domain
      pfam17061
      Location:243 → 400
      PARM; PARM

    2. XM_006237931.5 → XP_006237993.1  NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X2

      See identical proteins and their annotated locations for XP_006237993.1

      UniProtKB/TrEMBL
      Q4V8H7
      Conserved Domains (6) summary
      cd04021
      Location:17 → 140
      C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
      smart00119
      Location:587 → 915
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:564 → 916
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd00201
      Location:495 → 524
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      pfam00397
      Location:347 → 376
      WW; WW domain
      pfam17061
      Location:193 → 350
      PARM; PARM

    3. XM_008763591.4 → XP_008761813.1  NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X3

      Conserved Domains (4) summary
      smart00119
      Location:331 → 659
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:308 → 660
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd00201
      Location:239 → 268
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      pfam00397
      Location:91 → 120
      WW; WW domain
    Nucleotide Protein Strain
    Heading Accession and Version

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