Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cyp19a1provided by MGI
Official Full Name: cytochrome P450, family 19, subfamily a, polypeptide 1provided by MGI
Primary source: MGI:MGI:88587
See related: Ensembl:ENSMUSG00000032274 AllianceGenome:MGI:88587
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ar; ArKO; Int5; Cyp19; Int-5; p450arom
Summary: Enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen. Acts upstream of or within several processes, including negative regulation of macrophage chemotaxis; reproductive structure development; and testosterone biosynthetic process. Predicted to be located in several cellular components, including dendritic spine; neuronal cell body; and synaptic vesicle. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including central nervous system; gonad; gonad primordium; retina; and stomach. Used to study Sjogren's syndrome and aromatase excess syndrome. Human ortholog(s) of this gene implicated in several diseases, including aromatase excess syndrome; bladder neck obstruction; endometriosis (multiple); ovarian disease (multiple); and prostate disease (multiple). Orthologous to human CYP19A1 (cytochrome P450 family 19 subfamily A member 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in ovary adult (RPKM 2.4) and testis adult (RPKM 1.0) See more
Orthologs: human all
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Genomic context

Location:: 9 A5.3; 9 29.49 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (54073221..54175448, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (54165937..54268164, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Casein kinase 1alpha mediates estradiol secretion via CYP19A1 expression in mouse ovarian granulosa cells.
Title: Casein kinase 1α mediates estradiol secretion via CYP19A1 expression in mouse ovarian granulosa cells.
Tripeptidyl peptidase II coordinates the homeostasis of calcium and lipids in the central nervous system and its depletion causes presenile dementia in female mice through calcium/lipid dyshomeostasis-induced autophagic degradation of CYP19A1.
Title: Tripeptidyl peptidase II coordinates the homeostasis of calcium and lipids in the central nervous system and its depletion causes presenile dementia in female mice through calcium/lipid dyshomeostasis-induced autophagic degradation of CYP19A1.
Overexpression of Estrogen Receptor alpha in Mammary Glands of Aging Mice Is Associated with a Proliferative Risk Signature and Generation of Estrogen Receptor alpha-Positive Mammary Adenocarcinomas.
Title: Overexpression of Estrogen Receptor α in Mammary Glands of Aging Mice Is Associated with a Proliferative Risk Signature and Generation of Estrogen Receptor α-Positive Mammary Adenocarcinomas.
Esr1 but Not CYP19A1 Overexpression in Mammary Epithelial Cells during Reproductive Senescence Induces Pregnancy-Like Proliferative Mammary Disease Responsive to Anti-Hormonals.
Title: Esr1 but Not CYP19A1 Overexpression in Mammary Epithelial Cells during Reproductive Senescence Induces Pregnancy-Like Proliferative Mammary Disease Responsive to Anti-Hormonals.
Hippocampal Aromatase Knockdown Aggravates Ovariectomy-Induced Spatial Memory Impairment, Abeta Accumulation and Neural Plasticity Deficiency in Adult Female Mice.
Title: Hippocampal Aromatase Knockdown Aggravates Ovariectomy-Induced Spatial Memory Impairment, Aβ Accumulation and Neural Plasticity Deficiency in Adult Female Mice.
Brain Aromatase and the Regulation of Sexual Activity in Male Mice.
Title: Brain Aromatase and the Regulation of Sexual Activity in Male Mice.
Changes in nucleus accumbens gene expression accompany sex-specific suppression of spontaneous physical activity in aromatase knockout mice.
Title: Changes in nucleus accumbens gene expression accompany sex-specific suppression of spontaneous physical activity in aromatase knockout mice.
Loss of aromatase in hematopoietic cells confers increased skeletal muscle expression of genes implicated in insulin signaling and mitochondrial function.
Title: Aromatase deficiency in hematopoietic cells improves glucose tolerance in male mice through skeletal muscle-specific effects.
Loss of Cyp19a1 expression results in mild hypospadias.
Title: A loss of estrogen signaling in the aromatase deficient mouse penis results in mild hypospadias.
data provide evidence of a local increase of aromatase expression by reelin. Regarding reproduction, this crosstalk may contribute to follicular stability and counteract luteinization in ovaries.
Title: Reelin and aromatase cooperate in ovarian follicle development.

Submit: New GeneRIF Correction See all GeneRIFs (75)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6)
Targeted (12) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AU048745 (e-PCR)
- UniSTS:145195

Cyp19a1 (e-PCR), detects polymorphism
- UniSTS:498228

Cyp19a1 (e-PCR), detects polymorphism
- UniSTS:256606

PMC35455P1 (e-PCR)
- UniSTS:273252

Cyp19a1 (e-PCR), detects polymorphism
- UniSTS:256886

Cyp19 (e-PCR), detects polymorphism
- UniSTS:141445

D00659 (e-PCR)
- UniSTS:159878

Cyp19a1 (e-PCR), detects polymorphism
- UniSTS:305547

Cyp19a1 (e-PCR), detects polymorphism
- UniSTS:546714

Cyp19a1 (e-PCR), detects polymorphism
- UniSTS:265646

NoName (e-PCR)
- UniSTS:484848

CYP19-3 (e-PCR)
- UniSTS:253945

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables aromatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables aromatase activity	ISO Inferred from Sequence Orthology more info
enables aromatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables heme binding	ISO Inferred from Sequence Orthology more info
enables heme binding	ISS Inferred from Sequence or Structural Similarity more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	IDA Inferred from Direct Assay more info	PubMed
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in C21-steroid hormone metabolic process	ISO Inferred from Sequence Orthology more info
involved_in androgen catabolic process	IEA Inferred from Electronic Annotation more info
involved_in androgen catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within androgen metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in androgen metabolic process	ISO Inferred from Sequence Orthology more info
involved_in calcineurin-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in estrogen biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within female genitalia development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in female gonad development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within female gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mammary gland development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of bone resorption	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of chronic inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of macrophage chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of estradiol secretion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of estradiol secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within prostate gland growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synapse structure or activity	ISO Inferred from Sequence Orthology more info
involved_in response to estradiol	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within testosterone biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within uterus development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in axon terminus	ISO Inferred from Sequence Orthology more info
located_in dendritic spine	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in synaptic vesicle	ISO Inferred from Sequence Orthology more info
located_in terminal bouton	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: aromatase

Names: CYPXIX; cytochrome P-450AROM; cytochrome P450 19A1; cytochrome P450, 19, aromatase; estrogen synthase

NP_001335100.1

EC 1.14.14.14

NP_001335101.1

EC 1.14.14.14

NP_001335102.1

EC 1.14.14.14

NP_031836.1

EC 1.14.14.14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001348171.1 → NP_001335100.1 aromatase

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein. Expression of this variant has been found in adipose tissue.

Source sequence(s)

AC159816, AC162180

Consensus CDS

CCDS23187.1

UniProtKB/Swiss-Prot

P28649

UniProtKB/TrEMBL

A0A1L1SUD6, Q3ZAT3

Conserved Domains (1) summary

pfam00067
Location:48 → 488

p450; Cytochrome P450
NM_001348172.1 → NP_001335101.1 aromatase

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein. Expression of this variant has been found in brain.

Source sequence(s)

AC159816, AC162180

Consensus CDS

CCDS23187.1

UniProtKB/Swiss-Prot

P28649

UniProtKB/TrEMBL

A0A1L1SUD6, Q3ZAT3

Conserved Domains (1) summary

pfam00067
Location:48 → 488

p450; Cytochrome P450
NM_001348173.1 → NP_001335102.1 aromatase

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein. Expression of this variant has been found in testis.

Source sequence(s)

AC159816, AC162180

Consensus CDS

CCDS23187.1

UniProtKB/Swiss-Prot

P28649

UniProtKB/TrEMBL

A0A1L1SUD6, Q3ZAT3

Conserved Domains (1) summary

pfam00067
Location:48 → 488

p450; Cytochrome P450
NM_007810.4 → NP_031836.1 aromatase

See identical proteins and their annotated locations for NP_031836.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3, and 4 encode the same protein. Expression of this variant has been found in gonads.

Source sequence(s)

AC159816, AC162180

Consensus CDS

CCDS23187.1

UniProtKB/Swiss-Prot

P28649

UniProtKB/TrEMBL

A0A1L1SUD6, Q3ZAT3

Related

ENSMUSP00000034811.8, ENSMUST00000034811.8

Conserved Domains (1) summary

pfam00067
Location:48 → 488

p450; Cytochrome P450