Cwc27 CWC27 spliceosome-associated protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cwc27provided by MGI
Official Full Name: CWC27 spliceosome-associated proteinprovided by MGI
Primary source: MGI:MGI:1914535
See related: Ensembl:ENSMUSG00000021715 AllianceGenome:MGI:1914535
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: NY-CO-10; Sdccag10; 3110009E13Rik
Summary: Predicted to enable peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein folding. Located in nucleus. Is expressed in alimentary system; brain; genitourinary system; and trachea. Used to study retinitis pigmentosa. Orthologous to human CWC27 (CWC27 spliceosome associated cyclophilin). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in CNS E11.5 (RPKM 1.3), CNS E14 (RPKM 0.7) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 D1; 13 56.64 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (104767648..104953649, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (104631140..104817110, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cwc27, associated with retinal degeneration, functions as a splicing factor in vivo.
Title: Cwc27, associated with retinal degeneration, functions as a splicing factor in vivo.
Cwc27 mutant mice have significant embryonic lethality and severe phenotypes in the complete knockout mice while mice with a partial loss-of-function allele mimic the isolated retinal degeneration phenotype.
Title: Mutations in the Spliceosome Component CWC27 Cause Retinal Degeneration with or without Additional Developmental Anomalies.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation
Gene trapped (1)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables peptidyl-prolyl cis-trans isomerase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in protein folding	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein folding	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of U2-type precatalytic spliceosome	ISO Inferred from Sequence Orthology more info
part_of U2-type precatalytic spliceosome	ISS Inferred from Sequence or Structural Similarity more info
part_of catalytic step 2 spliceosome	IBA Inferred from Biological aspect of Ancestor more info
part_of catalytic step 2 spliceosome	IEA Inferred from Electronic Annotation more info
part_of catalytic step 2 spliceosome	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: spliceosome-associated protein CWC27 homolog

Names: CWC27 spliceosome-associated protein homolog; PPIase CWC27; PPIase SDCCAG10; peptidyl-prolyl cis-trans isomerase CWC27 homolog; peptidyl-prolyl cis-trans isomerase SDCCAG10; probable inactive peptidyl-prolyl cis-trans isomerase CWC27 homolog; serologically defined colon cancer antigen 10

NP_001347023.1

EC 5.2.1.8

NP_080348.1

EC 5.2.1.8

XP_017171062.1

EC 5.2.1.8

XP_017171063.1

EC 5.2.1.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001360094.1 → NP_001347023.1 spliceosome-associated protein CWC27 homolog isoform 2

Status: VALIDATED

Source sequence(s)

AC132905, AC137691

Conserved Domains (1) summary

cd01925
Location:8 → 178

cyclophilin_CeCYP16-like; cyclophilin_CeCYP16-like: cyclophilin-type peptidylprolyl cis- trans isomerase) (PPIase) domain similar to Caenorhabditis elegans cyclophilin 16. C. elegans CeCYP-16, compared to the archetypal cyclophilin Human cyclophilin A has, a reduced ...
NM_026072.1 → NP_080348.1 spliceosome-associated protein CWC27 homolog isoform 1

See identical proteins and their annotated locations for NP_080348.1

Status: VALIDATED

Source sequence(s)

AK166770

Consensus CDS

CCDS26752.1

UniProtKB/Swiss-Prot

Q3TKY6, Q8BG42, Q8R158, Q9CXT1

Related

ENSMUSP00000022228.7, ENSMUST00000022228.13

Conserved Domains (1) summary

cd01925
Location:8 → 178

cyclophilin_CeCYP16-like; cyclophilin_CeCYP16-like: cyclophilin-type peptidylprolyl cis- trans isomerase) (PPIase) domain similar to Caenorhabditis elegans cyclophilin 16. C. elegans CeCYP-16, compared to the archetypal cyclophilin Human cyclophilin A has, a reduced ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

104767648..104953649 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017315573.3 → XP_017171062.1 spliceosome-associated protein CWC27 homolog isoform X1

Conserved Domains (1) summary

cd01925
Location:8 → 178

cyclophilin_CeCYP16-like; cyclophilin-type peptidylprolyl cis- trans isomerase) (PPIase) domain similar to Caenorhabditis elegans cyclophilin 16. C. elegans CeCYP-16, compared to the archetypal cyclophilin Human cyclophilin A has, a reduced peptidylprolyl cis- trans isomerase ...
XM_017315574.3 → XP_017171063.1 spliceosome-associated protein CWC27 homolog isoform X2

Conserved Domains (1) summary

cd01925
Location:8 → 178

cyclophilin_CeCYP16-like; cyclophilin-type peptidylprolyl cis- trans isomerase) (PPIase) domain similar to Caenorhabditis elegans cyclophilin 16. C. elegans CeCYP-16, compared to the archetypal cyclophilin Human cyclophilin A has, a reduced peptidylprolyl cis- trans isomerase ...