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    Ubxn2b UBX domain protein 2B [ Mus musculus (house mouse) ]

    Gene ID: 68053, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ubxn2bprovided by MGI
    Official Full Name
    UBX domain protein 2Bprovided by MGI
    Primary source
    MGI:MGI:1915303
    See related
    Ensembl:ENSMUSG00000028243 AllianceGenome:MGI:1915303
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p37; 3110003A22Rik; 6430407D20Rik
    Summary
    Predicted to enable ubiquitin binding activity. Predicted to be involved in several processes, including establishment of mitotic spindle orientation; negative regulation of protein localization to centrosome; and positive regulation of mitotic centrosome separation. Located in spindle pole centrosome. Orthologous to human UBXN2B (UBX domain protein 2B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in liver E14 (RPKM 5.9), CNS E18 (RPKM 5.1) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ubxn2b in Genome Data Viewer
    Location:
    4 A1; 4 2.91 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (6191105..6219788)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (6191105..6219788)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 46 pseudogene Neighboring gene Ras suppressor protein 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_09476 Neighboring gene STARR-positive B cell enhancer ABC_E3480 Neighboring gene Cyp7a1 promoter Neighboring gene STARR-seq mESC enhancer starr_09478 Neighboring gene STARR-seq mESC enhancer starr_09479 Neighboring gene cytochrome P450, family 7, subfamily a, polypeptide 1 Neighboring gene RIKEN cDNA 4930430E12 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A novel active site-directed probe specific for deubiquitylating enzymes reveals proteasome association of USP14. Borodovsky A, et al. EMBO J, 2001 Sep 17. PMID 11566882, Free PMC Article
    2. Targeted substrate loop insertion by VCP/p97 during PP1 complex disassembly. van den Boom J, et al. Nat Struct Mol Biol, 2021 Dec. PMID 34824462
    3. p37 is a p97 adaptor required for Golgi and ER biogenesis in interphase and at the end of mitosis. Uchiyama K, et al. Dev Cell, 2006 Dec. PMID 17141156
    4. The UBXN-2/p37/p47 adaptors of CDC-48/p97 regulate mitosis by limiting the centrosomal recruitment of Aurora A. Kress E, et al. J Cell Biol, 2013 May 13. PMID 23649807, Free PMC Article
    5. An Interaction Landscape of Ubiquitin Signaling. Zhang X, et al. Mol Cell, 2017 Mar 2. PMID 28190767

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ubiquitin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in establishment of mitotic spindle orientation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in establishment of mitotic spindle orientation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in membrane fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of protein localization to centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of protein localization to centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nuclear membrane reassembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of mitotic centrosome separation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of mitotic centrosome separation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle pole centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    UBX domain-containing protein 2B
    Names
    NSFL1 cofactor p37
    p97 cofactor p37

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026534.2 → NP_080810.2  UBX domain-containing protein 2B

      See identical proteins and their annotated locations for NP_080810.2

      Status: VALIDATED

      Source sequence(s)
      BC076632, BY745604
      Consensus CDS
      CCDS17949.1
      UniProtKB/Swiss-Prot
      Q0KL01, Q8BGY8, Q8CCQ0, Q9CZA8
      Related
      ENSMUSP00000029907.6, ENSMUST00000029907.6
      Conserved Domains (2) summary
      cd01770
      Location:255 → 331
      p47_UBX; p47-like ubiquitin domain
      smart00553
      Location:140 → 232
      SEP; Domain present in Saccharomyces cerevisiae Shp1, Drosophila melanogaster eyes closed gene (eyc), and vertebrate p47

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      6191105..6219788
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0KL01.2 GenPept UniProtKB/Swiss-Prot:Q0KL01

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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