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    Ube2s ubiquitin-conjugating enzyme E2S [ Mus musculus (house mouse) ]

    Gene ID: 77891, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ube2sprovided by MGI
    Official Full Name
    ubiquitin-conjugating enzyme E2Sprovided by MGI
    Primary source
    MGI:MGI:1925141
    See related
    Ensembl:ENSMUSG00000060860 AllianceGenome:MGI:1925141
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    E2-EPF; 0910001J09Rik; 6720465F12Rik
    Summary
    Predicted to enable anaphase-promoting complex binding activity and ubiquitin conjugating enzyme activity. Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in several processes, including anaphase-promoting complex-dependent catabolic process; exit from mitosis; and protein polyubiquitination. Predicted to be part of anaphase-promoting complex. Predicted to be active in nucleus. Orthologous to human UBE2S (ubiquitin conjugating enzyme E2 S). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 313.9), thymus adult (RPKM 179.6) and 27 other tissues See more
    Orthologs
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    Genomic context

    See Ube2s in Genome Data Viewer
    Location:
    7 A1; 7 2.78 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (4811013..4815339, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (4808014..4812340, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 238 Neighboring gene STARR-positive B cell enhancer ABC_E6507 Neighboring gene predicted gene, 57780 Neighboring gene ribosomal protein L28 Neighboring gene STARR-positive B cell enhancer ABC_E441 Neighboring gene STARR-seq mESC enhancer starr_17941 Neighboring gene shisa family member 7 Neighboring gene predicted gene, 36127 Neighboring gene isochorismatase domain containing 2b Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:4817662-4817771 Neighboring gene predicted gene, 53350

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC101982

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding  
    enables anaphase-promoting complex binding  
    enables ubiquitin conjugating enzyme activity  
    enables ubiquitin conjugating enzyme activity  
    contributes_to ubiquitin-protein transferase activity  
    enables ubiquitin-protein transferase activity  
    contributes_to ubiquitin-protein transferase activity  
    Process Evidence Code Pubs
    involved_in anaphase-promoting complex-dependent catabolic process  
    involved_in anaphase-promoting complex-dependent catabolic process  
    involved_in cell division  
    involved_in exit from mitosis  
    involved_in exit from mitosis  
    involved_in free ubiquitin chain polymerization  
    involved_in free ubiquitin chain polymerization  
    involved_in positive regulation of ubiquitin protein ligase activity  
    involved_in positive regulation of ubiquitin protein ligase activity  
    acts_upstream_of_or_within protein K11-linked ubiquitination  
    involved_in protein K11-linked ubiquitination  
    involved_in protein K11-linked ubiquitination  
    involved_in protein K27-linked ubiquitination  
    involved_in protein K27-linked ubiquitination  
    involved_in protein K29-linked ubiquitination  
    involved_in protein K29-linked ubiquitination  
    involved_in protein K6-linked ubiquitination  
    involved_in protein K6-linked ubiquitination  
    involved_in protein K63-linked ubiquitination  
    involved_in protein K63-linked ubiquitination  
    involved_in protein polyubiquitination  
    involved_in ubiquitin-dependent protein catabolic process  
    Component Evidence Code Pubs
    part_of anaphase-promoting complex  
    part_of anaphase-promoting complex  
    is_active_in nucleus  

    General protein information

    Preferred Names
    ubiquitin-conjugating enzyme E2 S
    Names
    E2 ubiquitin-conjugating enzyme S
    E2-EPF5
    ubiquitin carrier protein S
    ubiquitin-conjugating enzyme E2-24 kDa
    ubiquitin-conjugating enzyme E2-EPF5
    ubiquitin-protein ligase S
    NP_598538.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133777.2NP_598538.1  ubiquitin-conjugating enzyme E2 S

      See identical proteins and their annotated locations for NP_598538.1

      Status: PROVISIONAL

      Source sequence(s)
      AC162034
      Consensus CDS
      CCDS39743.1
      UniProtKB/Swiss-Prot
      Q3U4V7, Q8CF67, Q921J4
      UniProtKB/TrEMBL
      A0A6I8MX03
      Related
      ENSMUSP00000078459.8, ENSMUST00000079496.9
      Conserved Domains (1) summary
      pfam00179
      Location:16152
      UQ_con; Ubiquitin-conjugating enzyme

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      4811013..4815339 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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