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    Calhm2 calcium homeostasis modulator family member 2 [ Mus musculus (house mouse) ]

    Gene ID: 72691, updated on 9-Dec-2024

    Summary

    Official Symbol
    Calhm2provided by MGI
    Official Full Name
    calcium homeostasis modulator family member 2provided by MGI
    Primary source
    MGI:MGI:1919941
    See related
    Ensembl:ENSMUSG00000033033 AllianceGenome:MGI:1919941
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fam26b; 2810048G17Rik
    Summary
    Predicted to enable monoatomic cation channel activity. Involved in several processes, including ATP export; calcium ion import; and regulation of microglial cell activation. Located in plasma membrane. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system gland; and skin. Orthologous to human CALHM2 (calcium homeostasis modulator family member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in spleen adult (RPKM 27.6), lung adult (RPKM 13.0) and 18 other tissues See more
    Orthologs
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    Genomic context

    See Calhm2 in Genome Data Viewer
    Location:
    19 C3; 19 39.28 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (47120671..47126733, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (47132232..47138294, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene TATA-box binding protein associated factor 5 Neighboring gene STARR-positive B cell enhancer ABC_E11038 Neighboring gene ATP synthase membrane subunit k Neighboring gene programmed cell death 11 Neighboring gene STARR-positive B cell enhancer ABC_E11039 Neighboring gene STARR-positive B cell enhancer ABC_E8754 Neighboring gene STARR-seq mESC enhancer starr_46339 Neighboring gene calcium homeostasis modulator 1 Neighboring gene STARR-seq mESC enhancer starr_46340 Neighboring gene calcium homeostasis modulator 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (3)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables monoatomic cation channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in ATP export IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ATP export ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in calcium ion import IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of microglial cell activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of synaptic plasticity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    calcium homeostasis modulator protein 2
    Names
    calcium homeostasis modulator 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133746.5NP_598507.3  calcium homeostasis modulator protein 2

      See identical proteins and their annotated locations for NP_598507.3

      Status: VALIDATED

      Source sequence(s)
      AK040739, BC096564
      Consensus CDS
      CCDS29889.1
      UniProtKB/Swiss-Prot
      Q3TDQ7, Q8BT85, Q8C246, Q8VEC4
      UniProtKB/TrEMBL
      Q3V3G1
      Related
      ENSMUSP00000047278.2, ENSMUST00000035822.2
      Conserved Domains (1) summary
      pfam14798
      Location:9256
      Ca_hom_mod; Calcium homeostasis modulator

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      47120671..47126733 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)