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    Dynlt3 dynein light chain Tctex-type 3 [ Mus musculus (house mouse) ]

    Gene ID: 67117, updated on 9-Dec-2024

    Summary

    Official Symbol
    Dynlt3provided by MGI
    Official Full Name
    dynein light chain Tctex-type 3provided by MGI
    Primary source
    MGI:MGI:1914367
    See related
    Ensembl:ENSMUSG00000031176 AllianceGenome:MGI:1914367
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tcte1l; 2310075M16Rik
    Summary
    Predicted to enable dynein intermediate chain binding activity and identical protein binding activity. Predicted to be involved in microtubule-based movement and positive regulation of mitotic cell cycle. Predicted to be located in mitotic spindle astral microtubule. Predicted to be part of cytoplasmic dynein complex. Predicted to be active in cytoplasm. Predicted to colocalize with kinetochore. Is expressed in several structures, including central nervous system; gut; lower urinary tract; nose; and submandibular gland primordium. Orthologous to human DYNLT3 (dynein light chain Tctex-type 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in bladder adult (RPKM 53.0), cerebellum adult (RPKM 34.0) and 20 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Dynlt3 in Genome Data Viewer
    Location:
    X A1.1; X 4.47 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (9520509..9529222, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (9654270..9662983, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 25728 Neighboring gene H2A histone family member L1O Neighboring gene STARR-seq mESC enhancer starr_46712 Neighboring gene STARR-seq mESC enhancer starr_46713 Neighboring gene synaptotagmin-like 5 Neighboring gene STARR-seq mESC enhancer starr_46715 Neighboring gene H2A histone family member L3 Neighboring gene H2A.P histone

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables dynein intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of mitotic cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of cytoplasmic dynein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of cytoplasmic dynein complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of cytoplasmic dynein complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    colocalizes_with kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with kinetochore ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in mitotic spindle astral microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitotic spindle astral microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    dynein light chain Tctex-type 3
    Names
    protein 91/23

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025975.5NP_080251.3  dynein light chain Tctex-type 3

      Status: VALIDATED

      Source sequence(s)
      AL671118
      Consensus CDS
      CCDS30011.1
      UniProtKB/Swiss-Prot
      P56387
      UniProtKB/TrEMBL
      Q542J7, Q9D2T5
      Related
      ENSMUSP00000033519.3, ENSMUST00000033519.3
      Conserved Domains (1) summary
      pfam03645
      Location:17113
      Tctex-1; Tctex-1 family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      9520509..9529222 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)