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    Casp8 caspase 8 [ Mus musculus (house mouse) ]

    Gene ID: 12370, updated on 3-Dec-2024

    Summary

    Official Symbol
    Casp8provided by MGI
    Official Full Name
    caspase 8provided by MGI
    Primary source
    MGI:MGI:1261423
    See related
    Ensembl:ENSMUSG00000026029 AllianceGenome:MGI:1261423
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MACH; Mch5; FLICE; CASP-8
    Summary
    This gene is part of a family of caspases, aspartate-specific cysteine proteases well studied for their involvement in immune and apoptosis signaling. This protein, an initiator of apoptotic cell death, is activated by death-inducing tumor necrosis family receptors and targets downstream effectors. In mouse deficiency of this gene can cause embryonic lethality. This protein may have a role in embryogenesis. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Apr 2013]
    Expression
    Ubiquitous expression in large intestine adult (RPKM 8.9), bladder adult (RPKM 4.8) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Casp8 in Genome Data Viewer
    Location:
    1 C1.3; 1 29.19 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (58834553..58886663)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (58795233..58847503)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E790 Neighboring gene STARR-positive B cell enhancer ABC_E5758 Neighboring gene CASP8 and FADD-like apoptosis regulator Neighboring gene STARR-seq mESC enhancer starr_01021 Neighboring gene STARR-seq mESC enhancer starr_01022 Neighboring gene STARR-positive B cell enhancer ABC_E1220 Neighboring gene STARR-seq mESC enhancer starr_01023 Neighboring gene predicted gene, 39646 Neighboring gene STARR-positive B cell enhancer mm9_chr1:58854474-58854775 Neighboring gene predicted gene 28802 Neighboring gene STARR-seq mESC enhancer starr_01024 Neighboring gene STARR-seq mESC enhancer starr_01025 Neighboring gene trafficking protein, kinesin binding 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:59013204-59013435 Neighboring gene STARR-seq mESC enhancer starr_01027 Neighboring gene STARR-positive B cell enhancer ABC_E982 Neighboring gene STE20-related kinase adaptor beta

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase activator activity involved in apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cysteine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cysteine-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cysteine-type endopeptidase activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    enables cysteine-type endopeptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables cysteine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables death effector domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables death receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables endopeptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables peptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables peptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables peptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables scaffold protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables tumor necrosis factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in TRAIL-activated apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in activation of cysteine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within apoptotic signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cardiac muscle tissue development TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in execution phase of apoptosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in execution phase of apoptosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in execution phase of apoptosis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within extrinsic apoptotic signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within extrinsic apoptotic signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in extrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in extrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in extrinsic apoptotic signaling pathway via death domain receptors IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within extrinsic apoptotic signaling pathway via death domain receptors IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in extrinsic apoptotic signaling pathway via death domain receptors TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within heart development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in heart development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within hepatocyte apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in macrophage differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within macrophage differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in macrophage differentiation TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of necroptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of necroptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of necroptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of necroptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neural tube formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of cysteine-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of execution phase of apoptosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of execution phase of apoptosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of extrinsic apoptotic signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of interleukin-1 beta production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of macrophage differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neuron apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein maturation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein processing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in proteolysis involved in protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in proteolysis involved in protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in pyroptotic inflammatory response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in pyroptotic inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of apoptotic signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of cytokine production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of innate immune response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within regulation of thymocyte apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in response to ethanol ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to tumor necrosis factor ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in self proteolysis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of CD95 death-inducing signaling complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of CD95 death-inducing signaling complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of Noc1p-Noc2p complex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in cell body ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    part_of death-inducing signaling complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion HDA PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of ripoptosome ISO
    Inferred from Sequence Orthology
    more info
     
    part_of ripoptosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    caspase-8
    Names
    Fas-linked ICE-like protease
    NP_001073595.1
    NP_001264855.2
    NP_001406970.1
    NP_001406971.1
    NP_001406972.1
    NP_001406973.1
    NP_001406974.1
    NP_001406975.1
    NP_001406976.1
    NP_001406978.1
    NP_001406979.1
    NP_033942.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080126.2NP_001073595.1  caspase-8 isoform 1

      See identical proteins and their annotated locations for NP_001073595.1

      Status: REVIEWED

      Source sequence(s)
      AC112968, AC120554
      Consensus CDS
      CCDS14979.1
      UniProtKB/Swiss-Prot
      O35669, O89110
      UniProtKB/TrEMBL
      Q3U607, Q4FK85
      Related
      ENSMUSP00000127375.2, ENSMUST00000165549.8
      Conserved Domains (3) summary
      cd00032
      Location:227479
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
      cd08333
      Location:384
      DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8
      cl14633
      Location:98179
      DD; Death Domain Superfamily of protein-protein interaction domains
    2. NM_001277926.2NP_001264855.2  caspase-8 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC112968, AC120554
      Consensus CDS
      CCDS78590.1
      UniProtKB/Swiss-Prot
      O35669, O89110
      UniProtKB/TrEMBL
      Q3U607, Q4FK85
      Related
      ENSMUSP00000140335.2, ENSMUST00000190213.2
    3. NM_001420041.1NP_001406970.1  caspase-8 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC112968, AC120554
      UniProtKB/Swiss-Prot
      O35669, O89110
      UniProtKB/TrEMBL
      Q3U607, Q4FK85
      Related
      ENSMUSP00000140546.2, ENSMUST00000191201.7
    4. NM_001420042.1NP_001406971.1  caspase-8 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC112968, AC120554
      UniProtKB/Swiss-Prot
      O35669, O89110
      UniProtKB/TrEMBL
      Q3U607, Q4FK85
    5. NM_001420043.1NP_001406972.1  caspase-8 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC112968, AC120554
      UniProtKB/Swiss-Prot
      O35669, O89110
      UniProtKB/TrEMBL
      Q3U607, Q4FK85
    6. NM_001420044.1NP_001406973.1  caspase-8 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC112968, AC120554
      UniProtKB/TrEMBL
      Q4FK85
    7. NM_001420045.1NP_001406974.1  caspase-8 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC112968, AC120554
      UniProtKB/TrEMBL
      Q4FK85
    8. NM_001420046.1NP_001406975.1  caspase-8 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC112968, AC120554
      UniProtKB/TrEMBL
      Q4FK85
    9. NM_001420047.1NP_001406976.1  caspase-8 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC112968, AC120554
      UniProtKB/TrEMBL
      Q4FK85
    10. NM_001420049.1NP_001406978.1  caspase-8 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC112968, AC120554
      UniProtKB/TrEMBL
      Q4FK85
    11. NM_001420050.1NP_001406979.1  caspase-8 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC112968, AC120554
    12. NM_009812.3NP_033942.1  caspase-8 isoform 1

      See identical proteins and their annotated locations for NP_033942.1

      Status: REVIEWED

      Source sequence(s)
      AC112968, AC120554
      Consensus CDS
      CCDS14979.1
      UniProtKB/Swiss-Prot
      O35669, O89110
      UniProtKB/TrEMBL
      Q3U607, Q4FK85
      Related
      ENSMUSP00000027189.9, ENSMUST00000027189.15
      Conserved Domains (3) summary
      cd00032
      Location:227479
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
      cd08333
      Location:384
      DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8
      cl14633
      Location:98179
      DD; Death Domain Superfamily of protein-protein interaction domains

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      58834553..58886663
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)