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    Csf1 colony stimulating factor 1 (macrophage) [ Mus musculus (house mouse) ]

    Gene ID: 12977, updated on 9-Dec-2024

    Summary

    Official Symbol
    Csf1provided by MGI
    Official Full Name
    colony stimulating factor 1 (macrophage)provided by MGI
    Primary source
    MGI:MGI:1339753
    See related
    Ensembl:ENSMUSG00000014599 AllianceGenome:MGI:1339753
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    op; Csfm; MCSF; BAP025; PG-M-CSF; Mhdabap25
    Summary
    Enables macrophage colony-stimulating factor receptor binding activity and protein homodimerization activity. Involved in several processes, including macrophage colony-stimulating factor signaling pathway; microglial cell proliferation; and positive regulation of gene expression. Acts upstream of or within several processes, including macrophage homeostasis; mammary gland development; and positive regulation of myeloid leukocyte differentiation. Located in extracellular space. Part of CSF1-CSF1R complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and long bone. Used to study osteopetrosis. Human ortholog(s) of this gene implicated in interstitial cystitis. Orthologous to human CSF1 (colony stimulating factor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in spleen adult (RPKM 14.8), mammary gland adult (RPKM 13.9) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Csf1 in Genome Data Viewer
    Location:
    3 F2.3; 3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (107648364..107668048, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (107741048..107760469, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene 10961 Neighboring gene S-adenosylhomocysteine hydrolase-like 1 Neighboring gene predicted gene, 52629 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:107499306-107499489 Neighboring gene predicted gene, 40121 Neighboring gene STARR-seq mESC enhancer starr_08670 Neighboring gene uncharacterized LOC118568636 Neighboring gene STARR-seq mESC enhancer starr_08675 Neighboring gene STARR-positive B cell enhancer ABC_E11209 Neighboring gene 60S ribosomal protein L13-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1)  1 citation
    • Endonuclease-mediated (6) 
    • Spontaneous (1) 
    • Targeted (5)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cytokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cytokine activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables growth factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables macrophage colony-stimulating factor receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of Ras protein signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within branching involved in mammary gland duct morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell surface receptor protein tyrosine kinase signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in developmental process involved in reproduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within homeostasis of number of cells within a tissue IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in macrophage colony-stimulating factor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of macrophage differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in macrophage differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within macrophage homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within mammary duct terminal end bud growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within mammary gland fat development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in microglial cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of monocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within monocyte homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of myeloid leukocyte migration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within neutrophil homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ossification ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in osteoclast differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within osteoclast differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of osteoclast differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of osteoclast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in osteoclast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within osteoclast proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of Ras protein signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of cell-matrix adhesion IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of leukocyte migration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of macrophage chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of macrophage chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of macrophage colony-stimulating factor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of macrophage colony-stimulating factor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of macrophage derived foam cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of macrophage derived foam cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of macrophage differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within positive regulation of macrophage differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of macrophage differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of macrophage migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of macrophage proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of microglial cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of microglial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of monocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of mononuclear cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of mononuclear cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of mononuclear cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of odontogenesis of dentin-containing tooth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of osteoclast differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of osteoclast differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of osteoclast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of osteoclast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of protein kinase activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of protein metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of protein metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of ossification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to ischemia IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to ischemia ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of CSF1-CSF1R complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    located_in extracellular space HDA PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    macrophage colony-stimulating factor 1
    Names
    osteopetrosis
    proteoglycan macrophage colony-stimulating factor
    NP_001107001.1
    NP_001107002.1
    NP_031804.3
    XP_036018771.1
    XP_036018772.1
    XP_036018773.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113529.1NP_001107001.1  macrophage colony-stimulating factor 1 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001107001.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in a shorter protein (isoform 2).
      Source sequence(s)
      AC140786, AI844210, S78392
      Consensus CDS
      CCDS51044.1
      UniProtKB/Swiss-Prot
      P07141
      Related
      ENSMUSP00000113136.2, ENSMUST00000118593.8
      Conserved Domains (1) summary
      pfam05337
      Location:1257
      CSF-1; Macrophage colony stimulating factor-1 (CSF-1)
    2. NM_001113530.1NP_001107002.1  macrophage colony-stimulating factor 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001107002.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR compared to variant 1. Variants 1 and 3 encode the same isoform.
      Source sequence(s)
      AC140786, CA328312, X05010
      Consensus CDS
      CCDS17740.1
      UniProtKB/Swiss-Prot
      P07141, Q3U395, Q8R3C8
      UniProtKB/TrEMBL
      Q3TDK0, Q3U4F9
      Related
      ENSMUSP00000113617.2, ENSMUST00000120243.8
      Conserved Domains (1) summary
      pfam05337
      Location:275552
      CSF-1; Macrophage colony stimulating factor-1 (CSF-1)
    3. NM_007778.4NP_031804.3  macrophage colony-stimulating factor 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_031804.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Variants 1 and 3 encode the same isoform.
      Source sequence(s)
      AC140786, AI844210, AK160995, BC066187
      Consensus CDS
      CCDS17740.1
      UniProtKB/Swiss-Prot
      P07141, Q3U395, Q8R3C8
      UniProtKB/TrEMBL
      Q3TDK0, Q3U4F9
      Related
      ENSMUSP00000014743.4, ENSMUST00000014743.10
      Conserved Domains (1) summary
      pfam05337
      Location:275552
      CSF-1; Macrophage colony stimulating factor-1 (CSF-1)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      107648364..107668048 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036162880.1XP_036018773.1  macrophage colony-stimulating factor 1 isoform X2

      Conserved Domains (1) summary
      pfam05337
      Location:65204
      CSF-1; Macrophage colony stimulating factor-1 (CSF-1)
    2. XM_036162878.1XP_036018771.1  macrophage colony-stimulating factor 1 isoform X1

      UniProtKB/TrEMBL
      Q3TDK0, Q3U4F9
      Conserved Domains (2) summary
      PHA03247
      Location:220496
      PHA03247; large tegument protein UL36; Provisional
      pfam05337
      Location:65204
      CSF-1; Macrophage colony stimulating factor-1 (CSF-1)
    3. XM_036162879.1XP_036018772.1  macrophage colony-stimulating factor 1 isoform X1

      UniProtKB/TrEMBL
      Q3TDK0, Q3U4F9
      Conserved Domains (2) summary
      PHA03247
      Location:220496
      PHA03247; large tegument protein UL36; Provisional
      pfam05337
      Location:65204
      CSF-1; Macrophage colony stimulating factor-1 (CSF-1)