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    Pip5k1a phosphatidylinositol-4-phosphate 5-kinase, type 1 alpha [ Mus musculus (house mouse) ]

    Gene ID: 18720, updated on 3-Dec-2024

    Summary

    Official Symbol
    Pip5k1aprovided by MGI
    Official Full Name
    phosphatidylinositol-4-phosphate 5-kinase, type 1 alphaprovided by MGI
    Primary source
    MGI:MGI:107929
    See related
    Ensembl:ENSMUSG00000028126 AllianceGenome:MGI:107929
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pipk5a; PI4P5K-I[a]; PIP5KIalpha; PIP5K1-alpha
    Summary
    Enables 1-phosphatidylinositol-4-phosphate 5-kinase activity. Acts upstream of or within fibroblast migration and phosphatidylinositol biosynthetic process. Located in cytosol; nucleus; and ruffle membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human PIP5K1A (phosphatidylinositol-4-phosphate 5-kinase type 1 alpha). [provided by Alliance of Genome Resources, Nov 2024]
    Annotation information
    Note: This record was renamed from Pip5k1b to Pip5k1a to conform to the annotation of human. [03 Apr 2007]
    Expression
    Ubiquitous expression in placenta adult (RPKM 12.5), limb E14.5 (RPKM 11.4) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Pip5k1a in Genome Data Viewer
    Location:
    3 F2.1; 3 40.74 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (94965841..95014241, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (95058530..95106930, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 687 Neighboring gene RIKEN cDNA 4930481B07 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:94820548-94820749 Neighboring gene STARR-positive B cell enhancer ABC_E4560 Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 Neighboring gene STARR-seq mESC enhancer starr_08364 Neighboring gene STARR-seq mESC enhancer starr_08366 Neighboring gene predicted gene, 24920 Neighboring gene predicted gene, 40095 Neighboring gene STARR-seq mESC enhancer starr_08367 Neighboring gene predicted gene, 22301 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:94914795-94915038 Neighboring gene vacuolar protein sorting 72 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:94937828-94938011 Neighboring gene tropomodulin 4 Neighboring gene sodium channel modifier 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol-4-phosphate 5-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables 1-phosphatidylinositol-4-phosphate 5-kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables 1-phosphatidylinositol-4-phosphate 5-kinase activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    enables 1-phosphatidylinositol-4-phosphate 5-kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables 1-phosphatidylinositol-4-phosphate 5-kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in actin cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in activation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in activation of GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cell chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell chemotaxis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within fibroblast migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in focal adhesion assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in focal adhesion assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within phosphatidylinositol biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within phosphatidylinositol metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in phosphatidylinositol phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in phospholipid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in ruffle assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ruffle assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lamellipodium IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
     
    part_of mRNA cleavage and polyadenylation specificity factor complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of mRNA cleavage and polyadenylation specificity factor complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear speck ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in ruffle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in ruffle membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    phosphatidylinositol 4-phosphate 5-kinase type-1 alpha
    Names
    68 kDa type I phosphatidylinositol 4-phosphate 5-kinase
    68 kDa type I phosphatidylinositol 4-phosphate 5-kinase alpha
    phosphatidylinositol 4-phosphate 5-kinase type I alpha
    ptdIns(4)P-5-kinase 1 alpha
    NP_001280636.1
    NP_032873.2
    XP_036018829.1
    XP_036018830.1
    XP_036018831.1
    XP_036018832.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001293707.2NP_001280636.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform 1

      See identical proteins and their annotated locations for NP_001280636.1

      Status: VALIDATED

      Source sequence(s)
      AC087062, AC131769
      Consensus CDS
      CCDS79980.1
      UniProtKB/TrEMBL
      F8WI18
      Related
      ENSMUSP00000102852.3, ENSMUST00000107233.9
      Conserved Domains (1) summary
      smart00330
      Location:95435
      PIPKc; Phosphatidylinositol phosphate kinases
    2. NM_001428682.1NP_001415611.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC087062, AC131769
      UniProtKB/TrEMBL
      D3YUY3
    3. NM_008847.4NP_032873.2  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform 2

      See identical proteins and their annotated locations for NP_032873.2

      Status: VALIDATED

      Source sequence(s)
      AC087062, AC131769
      Consensus CDS
      CCDS38542.1
      UniProtKB/Swiss-Prot
      F8WIX5, P70182, Q3U917, Q8K0D3, Q99L80
      UniProtKB/TrEMBL
      F8WI18
      Related
      ENSMUSP00000102855.3, ENSMUST00000107236.9
      Conserved Domains (1) summary
      smart00330
      Location:94434
      PIPKc; Phosphatidylinositol phosphate kinases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      94965841..95014241 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036162939.1XP_036018832.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X4

      Related
      ENSMUSP00000102851.3, ENSMUST00000107232.9
      Conserved Domains (1) summary
      cd17306
      Location:65439
      PIPKc_PIP5K1A_like; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (PIP5K1alpha) and similar proteins
    2. XM_036162937.1XP_036018830.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X2

      UniProtKB/TrEMBL
      D3YUY3
      Conserved Domains (1) summary
      cd17306
      Location:79453
      PIPKc_PIP5K1A_like; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (PIP5K1alpha) and similar proteins
    3. XM_036162936.1XP_036018829.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1

      UniProtKB/TrEMBL
      F8WI18
      Conserved Domains (1) summary
      cd17306
      Location:79454
      PIPKc_PIP5K1A_like; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (PIP5K1alpha) and similar proteins
    4. XM_036162938.1XP_036018831.1  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X3

      UniProtKB/TrEMBL
      F8WI18
      Conserved Domains (1) summary
      cd17306
      Location:22397
      PIPKc_PIP5K1A_like; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (PIP5K1alpha) and similar proteins

    RNA

    1. XR_375498.3 RNA Sequence

    2. XR_375499.3 RNA Sequence

    3. XR_004941296.1 RNA Sequence