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    Trim32 tripartite motif-containing 32 [ Mus musculus (house mouse) ]

    Gene ID: 69807, updated on 9-Dec-2024

    Summary

    Official Symbol
    Trim32provided by MGI
    Official Full Name
    tripartite motif-containing 32provided by MGI
    Primary source
    MGI:MGI:1917057
    See related
    Ensembl:ENSMUSG00000051675 AllianceGenome:MGI:1917057
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    3f3; BBS11; Zfp117; 1810045E12Rik
    Summary
    Enables several functions, including identical protein binding activity; translation initiation factor binding activity; and ubiquitin protein ligase activity. Involved in several processes, including positive regulation of NF-kappaB transcription factor activity; positive regulation of cell differentiation; and response to tumor necrosis factor. Acts upstream of or within several processes, including muscle cell cellular homeostasis; positive regulation of cytokine-mediated signaling pathway; and protein ubiquitination. Located in nucleus and striated muscle myosin thick filament. Is expressed in central nervous system and genitourinary system. Used to study autosomal recessive limb-girdle muscular dystrophy type 2H. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome; Bardet-Biedl syndrome 11; autosomal recessive limb-girdle muscular dystrophy type 2H; and muscular dystrophy. Orthologous to human TRIM32 (tripartite motif containing 32). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E18 (RPKM 39.0), whole brain E14.5 (RPKM 30.7) and 23 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Trim32 in Genome Data Viewer
    Location:
    4 C1; 4 34.43 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (65523223..65534477)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (65604986..65616240)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_10458 Neighboring gene predicted gene 11218 Neighboring gene STARR-seq mESC enhancer starr_10459 Neighboring gene STARR-seq mESC enhancer starr_10460 Neighboring gene VISTA enhancer mm774 Neighboring gene pregnancy-associated plasma protein A Neighboring gene STARR-seq mESC enhancer starr_10462 Neighboring gene STARR-seq mESC enhancer starr_10463 Neighboring gene astrotactin 2 Neighboring gene STARR-seq mESC enhancer starr_10465 Neighboring gene STARR-seq mESC enhancer starr_10466 Neighboring gene STARR-seq mESC enhancer starr_10467 Neighboring gene predicted gene, 31533 Neighboring gene STARR-seq mESC enhancer starr_10468 Neighboring gene STARR-seq mESC enhancer starr_10469 Neighboring gene STARR-seq mESC enhancer starr_10470 Neighboring gene STARR-seq mESC enhancer starr_10471 Neighboring gene STARR-seq mESC enhancer starr_10472 Neighboring gene STARR-seq mESC enhancer starr_10473 Neighboring gene STARR-seq mESC enhancer starr_10474 Neighboring gene STARR-seq mESC enhancer starr_10475 Neighboring gene STARR-seq mESC enhancer starr_10476 Neighboring gene predicted gene, 25480

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables myosin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-macromolecule adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription coactivator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables translation initiation factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin-protein transferase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within actin ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in autophagosome assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in autophagosome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within axon development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to amino acid starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular response to stress IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in fat cell differentiation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in free ubiquitin chain polymerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in free ubiquitin chain polymerization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in innate immune response ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within muscle cell cellular homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cilium assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cilium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of fibroblast proliferation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of keratinocyte apoptotic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of toll-like receptor 4 signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of toll-like receptor 4 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of viral transcription IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of viral transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of NF-kappaB transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of autophagosome assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of autophagosome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of autophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of autophagy ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of canonical NF-kappaB signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell growth ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cell motility IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of chemokine (C-C motif) ligand 20 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of interleukin-17-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of neurogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of neuron differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of proteolysis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within positive regulation of striated muscle cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of tumor necrosis factor-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within positive regulation of tumor necrosis factor-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein K63-linked ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein K63-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein polyubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein polyubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to UV IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to starvation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to starvation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to tumor necrosis factor IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in suppression of viral release by host IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in suppression of viral release by host ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within tissue homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in autophagosome IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in autophagosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in striated muscle myosin thick filament IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase TRIM32
    Names
    RING-type E3 ubiquitin transferase TRIM32
    bM468K2.2 (tripartite motif protein 32)
    tripartite motif protein 32
    tripartite motif-containing protein 32
    zinc finger protein 117
    NP_001155254.1
    NP_444314.2
    XP_006538298.1
    XP_006538299.1
    XP_006538300.1
    XP_006538301.1
    XP_030109625.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001161782.1NP_001155254.1  E3 ubiquitin-protein ligase TRIM32

      See identical proteins and their annotated locations for NP_001155254.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC034104, BE855341, BG073447, BY280460
      Consensus CDS
      CCDS18270.1
      UniProtKB/Swiss-Prot
      Q8CH72, Q8K055
      UniProtKB/TrEMBL
      Q3TLR3
      Related
      ENSMUSP00000102989.2, ENSMUST00000107366.2
      Conserved Domains (3) summary
      cd14961
      Location:364646
      NHL_TRIM32_like; NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins
      cd16587
      Location:2066
      RING-HC_TRIM32_C-VII; RING finger, HC subclass, found in tripartite motif-containing protein 32 (TRIM32) and similar proteins
      cd19806
      Location:99139
      Bbox1_TRIM32_C-VII; B-box-type 1 zinc finger found in tripartite motif-containing protein 32 (TRIM32) and similar proteins
    2. NM_053084.2NP_444314.2  E3 ubiquitin-protein ligase TRIM32

      See identical proteins and their annotated locations for NP_444314.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC034104, BE855341, BG073447, BY280460
      Consensus CDS
      CCDS18270.1
      UniProtKB/Swiss-Prot
      Q8CH72, Q8K055
      UniProtKB/TrEMBL
      Q3TLR3
      Related
      ENSMUSP00000062277.8, ENSMUST00000050850.14
      Conserved Domains (3) summary
      cd14961
      Location:364646
      NHL_TRIM32_like; NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins
      cd16587
      Location:2066
      RING-HC_TRIM32_C-VII; RING finger, HC subclass, found in tripartite motif-containing protein 32 (TRIM32) and similar proteins
      cd19806
      Location:99139
      Bbox1_TRIM32_C-VII; B-box-type 1 zinc finger found in tripartite motif-containing protein 32 (TRIM32) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      65523223..65534477
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006538235.2XP_006538298.1  E3 ubiquitin-protein ligase TRIM32 isoform X1

      See identical proteins and their annotated locations for XP_006538298.1

      UniProtKB/Swiss-Prot
      Q8CH72, Q8K055
      UniProtKB/TrEMBL
      Q3TLR3
      Conserved Domains (3) summary
      cd14961
      Location:364646
      NHL_TRIM32_like; NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins
      cd16587
      Location:2066
      RING-HC_TRIM32_C-VII; RING finger, HC subclass, found in tripartite motif-containing protein 32 (TRIM32) and similar proteins
      cd19806
      Location:99139
      Bbox1_TRIM32_C-VII; B-box-type 1 zinc finger found in tripartite motif-containing protein 32 (TRIM32) and similar proteins
    2. XM_006538238.3XP_006538301.1  E3 ubiquitin-protein ligase TRIM32 isoform X1

      See identical proteins and their annotated locations for XP_006538301.1

      UniProtKB/Swiss-Prot
      Q8CH72, Q8K055
      UniProtKB/TrEMBL
      Q3TLR3
      Conserved Domains (3) summary
      cd14961
      Location:364646
      NHL_TRIM32_like; NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins
      cd16587
      Location:2066
      RING-HC_TRIM32_C-VII; RING finger, HC subclass, found in tripartite motif-containing protein 32 (TRIM32) and similar proteins
      cd19806
      Location:99139
      Bbox1_TRIM32_C-VII; B-box-type 1 zinc finger found in tripartite motif-containing protein 32 (TRIM32) and similar proteins
    3. XM_006538236.5XP_006538299.1  E3 ubiquitin-protein ligase TRIM32 isoform X1

      See identical proteins and their annotated locations for XP_006538299.1

      UniProtKB/Swiss-Prot
      Q8CH72, Q8K055
      UniProtKB/TrEMBL
      Q3TLR3
      Conserved Domains (3) summary
      cd14961
      Location:364646
      NHL_TRIM32_like; NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins
      cd16587
      Location:2066
      RING-HC_TRIM32_C-VII; RING finger, HC subclass, found in tripartite motif-containing protein 32 (TRIM32) and similar proteins
      cd19806
      Location:99139
      Bbox1_TRIM32_C-VII; B-box-type 1 zinc finger found in tripartite motif-containing protein 32 (TRIM32) and similar proteins
    4. XM_006538237.2XP_006538300.1  E3 ubiquitin-protein ligase TRIM32 isoform X1

      See identical proteins and their annotated locations for XP_006538300.1

      UniProtKB/Swiss-Prot
      Q8CH72, Q8K055
      UniProtKB/TrEMBL
      Q3TLR3
      Conserved Domains (3) summary
      cd14961
      Location:364646
      NHL_TRIM32_like; NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins
      cd16587
      Location:2066
      RING-HC_TRIM32_C-VII; RING finger, HC subclass, found in tripartite motif-containing protein 32 (TRIM32) and similar proteins
      cd19806
      Location:99139
      Bbox1_TRIM32_C-VII; B-box-type 1 zinc finger found in tripartite motif-containing protein 32 (TRIM32) and similar proteins
    5. XM_030253765.2XP_030109625.1  E3 ubiquitin-protein ligase TRIM32 isoform X1

      UniProtKB/Swiss-Prot
      Q8CH72, Q8K055
      UniProtKB/TrEMBL
      Q3TLR3
      Conserved Domains (3) summary
      cd14961
      Location:364646
      NHL_TRIM32_like; NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins
      cd16587
      Location:2066
      RING-HC_TRIM32_C-VII; RING finger, HC subclass, found in tripartite motif-containing protein 32 (TRIM32) and similar proteins
      cd19806
      Location:99139
      Bbox1_TRIM32_C-VII; B-box-type 1 zinc finger found in tripartite motif-containing protein 32 (TRIM32) and similar proteins