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    Chst11 carbohydrate sulfotransferase 11 [ Mus musculus (house mouse) ]

    Gene ID: 58250, updated on 9-Dec-2024

    Summary

    Official Symbol
    Chst11provided by MGI
    Official Full Name
    carbohydrate sulfotransferase 11provided by MGI
    Primary source
    MGI:MGI:1927166
    See related
    Ensembl:ENSMUSG00000034612 AllianceGenome:MGI:1927166
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C4s; C4ST; C4ST1; C4ST-1; 1110020P09Rik
    Summary
    Enables N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity. Acts upstream of or within several processes, including chondroitin sulfate biosynthetic process; post-anal tail morphogenesis; and skeletal system development. Predicted to be located in Golgi membrane. Is expressed in several structures, including alimentary system; central nervous system; ear; heart; and skeletal system. Orthologous to human CHST11 (carbohydrate sulfotransferase 11). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in ovary adult (RPKM 37.7), adrenal adult (RPKM 14.0) and 20 other tissues See more
    Orthologs
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    Genomic context

    See Chst11 in Genome Data Viewer
    Location:
    10 C1; 10 40.66 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (82820274..83031738)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (82984440..83195904)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10633 Neighboring gene predicted gene, 33781 Neighboring gene predicted gene 4799 Neighboring gene STARR-seq mESC enhancer starr_27385 Neighboring gene STARR-seq mESC enhancer starr_27387 Neighboring gene RIKEN cDNA 1700025N21 gene Neighboring gene predicted gene, 53595 Neighboring gene solute carrier family 41, member 2 Neighboring gene STARR-seq mESC enhancer starr_27388 Neighboring gene STARR-positive B cell enhancer ABC_E2331 Neighboring gene STARR-seq mESC enhancer starr_27389 Neighboring gene predicted gene, 40722 Neighboring gene predicted gene, 40723

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables chondroitin 4-sulfotransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables chondroitin 4-sulfotransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables dermatan 4-sulfotransferase IEA
    Inferred from Electronic Annotation
    more info
     
    enables dermatan 4-sulfotransferase ISO
    Inferred from Sequence Orthology
    more info
     
    enables sulfotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables sulfotransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in carbohydrate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cartilage development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within chondrocyte development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within chondroitin sulfate biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within chondroitin sulfate biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in chondroitin sulfate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within chondroitin sulfate metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within developmental growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within embryonic digit morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within embryonic limb morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within embryonic skeletal system morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within embryonic viscerocranium morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of transforming growth factor beta receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within polysaccharide localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within post-anal tail morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within post-embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in proteoglycan biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within respiratory gaseous exchange by respiratory system IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of transforming growth factor beta receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    carbohydrate sulfotransferase 11
    Names
    C4S-1
    chondroitin 4
    chondroitin 4-O-sulfotransferase 1
    chondroitin 4-sulfotransferase 1
    NP_067414.2
    XP_006513971.1
    XP_006513972.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001429269.1NP_001416198.1  carbohydrate sulfotransferase 11

      Status: VALIDATED

      Source sequence(s)
      AC102114, AC155938, AC159149
      UniProtKB/TrEMBL
      B7ZMT9
    2. NM_021439.4NP_067414.2  carbohydrate sulfotransferase 11

      See identical proteins and their annotated locations for NP_067414.2

      Status: VALIDATED

      Source sequence(s)
      AC102114, AC155938, AC159149
      Consensus CDS
      CCDS24074.1
      UniProtKB/Swiss-Prot
      Q9JJS2, Q9JME2
      UniProtKB/TrEMBL
      B9EHC3
      Related
      ENSMUSP00000045349.8, ENSMUST00000040110.8
      Conserved Domains (1) summary
      pfam03567
      Location:113343
      Sulfotransfer_2; Sulfotransferase family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      82820274..83031738
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513909.4XP_006513972.1  carbohydrate sulfotransferase 11 isoform X2

      Conserved Domains (1) summary
      pfam03567
      Location:108338
      Sulfotransfer_2; Sulfotransferase family
    2. XM_006513908.5XP_006513971.1  carbohydrate sulfotransferase 11 isoform X1

      Conserved Domains (1) summary
      pfam03567
      Location:112342
      Sulfotransfer_2; Sulfotransferase family