Timm21 translocase of inner mitochondrial membrane 21 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Timm21provided by MGI
Official Full Name: translocase of inner mitochondrial membrane 21provided by MGI
Primary source: MGI:MGI:1920595
See related: Ensembl:ENSMUSG00000024645 AllianceGenome:MGI:1920595
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1700034H14Rik; 2700002I20Rik
Summary: Predicted to be involved in mitochondrial cytochrome c oxidase assembly; mitochondrial respiratory chain complex I assembly; and protein import into mitochondrial matrix. Located in mitochondrion. Orthologous to human TIMM21 (translocase of inner mitochondrial membrane 21). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 11.4), limb E14.5 (RPKM 10.0) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 E4; 18 57.53 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (84964316..84970168, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (84946191..84951530, complement)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in mitochondrial cytochrome c oxidase assembly	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial cytochrome c oxidase assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrial respiratory chain complex I assembly	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial respiratory chain complex I assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein import into mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein import into mitochondrial matrix	ISO Inferred from Sequence Orthology more info
involved_in protein import into mitochondrial matrix	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of TIM23 mitochondrial import inner membrane translocase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of TIM23 mitochondrial import inner membrane translocase complex	ISO Inferred from Sequence Orthology more info
part_of TIM23 mitochondrial import inner membrane translocase complex	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	HDA more info	PubMed

General protein information

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Preferred Names: mitochondrial import inner membrane translocase subunit Tim21

Names: TIM21-like protein, mitochondrial; tranlocase of inner mitochondrial membrane 21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_025969.5 → NP_080245.1 mitochondrial import inner membrane translocase subunit Tim21

See identical proteins and their annotated locations for NP_080245.1

Status: VALIDATED

Source sequence(s)

AC134545

Consensus CDS

CCDS29386.1

UniProtKB/Swiss-Prot

Q3THX0, Q8CCM6, Q8CE44, Q9CYU8, Q9CZS4

Related

ENSMUSP00000025547.3, ENSMUST00000025547.4

Conserved Domains (1) summary

pfam08294
Location:98 → 240

TIM21

RNA

NR_160856.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC134545

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000084.7 Reference GRCm39 C57BL/6J

Range

84964316..84970168 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011247094.4 → XP_011245396.1 mitochondrial import inner membrane translocase subunit Tim21 isoform X1

See identical proteins and their annotated locations for XP_011245396.1

UniProtKB/Swiss-Prot

Q8CCM6

Conserved Domains (1) summary

cl21648
Location:98 → 167

Coa1; Cytochrome oxidase complex assembly protein 1