Gstcd glutathione S-transferase, C-terminal domain containing [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gstcdprovided by MGI
Official Full Name: glutathione S-transferase, C-terminal domain containingprovided by MGI
Primary source: MGI:MGI:1914803
See related: Ensembl:ENSMUSG00000028018 AllianceGenome:MGI:1914803
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 4933434L15Rik
Summary: Predicted to be active in cytoplasm. Is expressed in ductus deferens and testis. Orthologous to human GSTCD (glutathione S-transferase C-terminal domain containing). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 7.0), testis adult (RPKM 6.2) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 G3; 3 61.54 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (132687511..132797800, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (132981750..133092039, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data potentially highlight an unrecognised function of GSTCD in mediating inflammatory signals that affect airway caliber, and may in part underlie the genetic associations seen at the GSTCD locus with lung function and COPD phenotypes.
Title: Exposure to lipopolysaccharide (LPS) reduces contractile response of small airways from GSTCD-/- mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: glutathione S-transferase C-terminal domain-containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001356309.1 → NP_001343238.1 glutathione S-transferase C-terminal domain-containing protein

Status: VALIDATED

Source sequence(s)

AC124593, BC061240

Consensus CDS

CCDS17847.1

UniProtKB/Swiss-Prot

Q5RL51, Q6P8I1, Q8BXR2, Q8BYY6, Q9CTV2, Q9CUA9, Q9CXU7

Related

ENSMUSP00000079421.6, ENSMUST00000080583.6

Conserved Domains (2) summary

cl02776
Location:271 → 330

GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family

cl17173
Location:424 → 542

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
NM_026231.3 → NP_080507.2 glutathione S-transferase C-terminal domain-containing protein

See identical proteins and their annotated locations for NP_080507.2

Status: VALIDATED

Source sequence(s)

AC124593, BC047136, BY740821

Consensus CDS

CCDS17847.1

UniProtKB/Swiss-Prot

Q5RL51, Q6P8I1, Q8BXR2, Q8BYY6, Q9CTV2, Q9CUA9, Q9CXU7

Related

ENSMUSP00000029651.5, ENSMUST00000029651.11

Conserved Domains (2) summary

cl02776
Location:271 → 330

GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family

cl17173
Location:424 → 542

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...