U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Pggt1b protein geranylgeranyltransferase type I, beta subunit [ Mus musculus (house mouse) ]

    Gene ID: 225467, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pggt1bprovided by MGI
    Official Full Name
    protein geranylgeranyltransferase type I, beta subunitprovided by MGI
    Primary source
    MGI:MGI:1917514
    See related
    Ensembl:ENSMUSG00000024477 AllianceGenome:MGI:1917514
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BGG1; GGT1; 2610100E13; 2010207C17Rik
    Summary
    Predicted to enable heterocyclic compound binding activity; protein geranylgeranyltransferase activity; and zinc ion binding activity. Predicted to contribute to CAAX-protein geranylgeranyltransferase activity; peptide binding activity; and small molecule binding activity. Predicted to be involved in several processes, including negative regulation of nitric-oxide synthase biosynthetic process; positive regulation of cell population proliferation; and protein geranylgeranylation. Part of CAAX-protein geranylgeranyltransferase complex. Orthologous to human PGGT1B (protein geranylgeranyltransferase type I subunit beta). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 4.5), bladder adult (RPKM 4.1) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Pggt1b in Genome Data Viewer
    Location:
    18 C; 18 24.45 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (46368411..46414173, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (46235344..46281089, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene tripartite motif-containing 36 Neighboring gene predicted gene, 52364 Neighboring gene STARR-positive B cell enhancer ABC_E9977 Neighboring gene STARR-seq mESC enhancer starr_44498 Neighboring gene coiled-coil domain containing 112 Neighboring gene STARR-positive B cell enhancer ABC_E1955 Neighboring gene STARR-seq mESC enhancer starr_44499 Neighboring gene STARR-seq mESC enhancer starr_44500 Neighboring gene STARR-seq mESC enhancer starr_44501 Neighboring gene STARR-seq mESC enhancer starr_44503 Neighboring gene predicted gene 4107 Neighboring gene symplekin pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (3)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to CAAX-protein geranylgeranyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    contributes_to CAAX-protein geranylgeranyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables CAAX-protein geranylgeranyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables CAAX-protein geranylgeranyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables heterocyclic compound binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to peptide binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein geranylgeranyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein geranylgeranyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    contributes_to small molecule binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in positive regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein geranylgeranylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein geranylgeranylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to cytokine ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of CAAX-protein geranylgeranyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of CAAX-protein geranylgeranyltransferase complex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    part_of CAAX-protein geranylgeranyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of CAAX-protein geranylgeranyltransferase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    geranylgeranyl transferase type-1 subunit beta
    Names
    GGTase-I-beta
    geranylgeranyl transferase type I subunit beta
    type I protein geranyl-geranyltransferase subunit beta
    NP_001404709.1
    NP_001404710.1
    NP_001404711.1
    NP_001404716.1
    NP_001404733.1
    NP_766215.1
    XP_036017005.1
    XP_036017006.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001417780.1NP_001404709.1  geranylgeranyl transferase type-1 subunit beta isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC124717
    2. NM_001417781.1NP_001404710.1  geranylgeranyl transferase type-1 subunit beta isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC124717
    3. NM_001417782.1NP_001404711.1  geranylgeranyl transferase type-1 subunit beta isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC124717
    4. NM_001417787.1NP_001404716.1  geranylgeranyl transferase type-1 subunit beta isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC124717
    5. NM_001417804.1NP_001404733.1  geranylgeranyl transferase type-1 subunit beta isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC124717
    6. NM_172627.4NP_766215.1  geranylgeranyl transferase type-1 subunit beta isoform 1

      See identical proteins and their annotated locations for NP_766215.1

      Status: VALIDATED

      Source sequence(s)
      AC124717
      Consensus CDS
      CCDS29230.1
      UniProtKB/Swiss-Prot
      Q8BUY9
      Related
      ENSMUSP00000158214.2, ENSMUST00000236216.2
      Conserved Domains (2) summary
      COG5029
      Location:21360
      CAL1; Prenyltransferase, beta subunit [Posttranslational modification, protein turnover, chaperones, Lipid transport and metabolism]
      cd02895
      Location:22332
      GGTase-I; Geranylgeranyltransferase types I (GGTase-I)-like proteins containing the protein prenyltransferase (PTase) domain, beta subunit (alpha 6 - alpha 6 barrel fold). GGTase-I s are a subgroup of the protein prenyltransferase family of lipid-modifying enzymes ...

    RNA

    1. NR_184581.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC124717
    2. NR_184582.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC124717
    3. NR_184583.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC124717
    4. NR_184584.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC124717
    5. NR_184585.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC124717

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      46368411..46414173 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161113.1XP_036017006.1  geranylgeranyl transferase type-1 subunit beta isoform X3

      Conserved Domains (1) summary
      cl08267
      Location:1194
      ISOPREN_C2_like; This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate ...
    2. XM_036161112.1XP_036017005.1  geranylgeranyl transferase type-1 subunit beta isoform X1

      Conserved Domains (1) summary
      cd02895
      Location:22317
      GGTase-I; Geranylgeranyltransferase types I (GGTase-I)-like proteins containing the protein prenyltransferase (PTase) domain, beta subunit (alpha 6 - alpha 6 barrel fold). GGTase-I s are a subgroup of the protein prenyltransferase family of lipid-modifying enzymes ...