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    Rcsd1 RCSD domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 226594, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Rcsd1provided by MGI
    Official Full Name
    RCSD domain containing 1provided by MGI
    Primary source
    MGI:MGI:2676394
    See related
    Ensembl:ENSMUSG00000040723 AllianceGenome:MGI:2676394
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CapZIP; Gm19627; A430105K13Rik
    Summary
    Predicted to enable actin filament binding activity; phosphatidylinositol phosphate binding activity; and retromer complex binding activity. Predicted to be involved in several processes, including cellular hyperosmotic response; protein localization to endosome; and retrograde transport, endosome to Golgi. Predicted to be part of WASH complex. Predicted to be active in early endosome. Is expressed in several structures, including blood; chondrocranium; gut; meninges; and metanephros. Orthologous to human RCSD1 (RCSD domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in thymus adult (RPKM 43.0), spleen adult (RPKM 17.7) and 15 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rcsd1 in Genome Data Viewer
    Location:
    1 H2.3; 1 72.99 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (165476503..165537632, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (165648945..165710063, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1570 Neighboring gene nuclear encoded tRNA proline 2 (anticodon CGG) Neighboring gene translin-associated factor X pseudogene Neighboring gene STARR-seq mESC enhancer starr_02911 Neighboring gene STARR-positive B cell enhancer mm9_chr1:167591001-167591302 Neighboring gene STARR-positive B cell enhancer ABC_E1571 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:167636283-167636436 Neighboring gene STARR-positive B cell enhancer ABC_E11104 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:167648574-167648683 Neighboring gene predicted gene, 51752 Neighboring gene STARR-positive B cell enhancer ABC_E1572 Neighboring gene STARR-positive B cell enhancer ABC_E4374 Neighboring gene cellular repressor of E1A-stimulated genes 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The CapZ interacting protein Rcsd1 is required for cardiogenesis downstream of Wnt11a in Xenopus laevis. Hempel A, et al. Dev Biol, 2017 Apr 1. PMID 28237811
    2. Efficient capture of cardiogenesis-associated genes expressed in ES cells. Terami H, et al. Biochem Biophys Res Commun, 2007 Mar 30. PMID 17286962
    3. The phosphorylation of CapZ-interacting protein (CapZIP) by stress-activated protein kinases triggers its dissociation from CapZ. Eyers CE, et al. Biochem J, 2005 Jul 1. PMID 15850461, Free PMC Article
    4. Permissive ureter specification by TBX18-mediated repression of metanephric gene expression. Weiss AC, et al. Development, 2023 Mar 15. PMID 36960826
    5. A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies. Breslow DK, et al. Nat Genet, 2018 Mar. PMID 29459677, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC32399

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables retromer complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular hyperosmotic response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular hyperosmotic response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retrograde transport, endosome to Golgi IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in skeletal muscle contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in skeletal muscle contraction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of WASH complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    capZ-interacting protein
    Names
    protein kinase substrate CapZIP

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001038846.1 → NP_001033935.1  capZ-interacting protein isoform b

      See identical proteins and their annotated locations for NP_001033935.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the coding region compared to variant 1. The resulting protein (isoform b) is shorter but has the same N- and C- termini compared to isoform a.
      Source sequence(s)
      AK168816, AK171323, BY230131
      Consensus CDS
      CCDS48425.1
      UniProtKB/Swiss-Prot
      Q3UZA1
      Related
      ENSMUSP00000095082.4, ENSMUST00000097474.9
      Conserved Domains (2) summary
      pfam05177
      Location:201 → 285
      RCSD; RCSD region
      pfam15255
      Location:51 → 136
      CAP-ZIP_m; WASH complex subunit CAP-Z interacting, central region

    2. NM_178593.3 → NP_848708.2  capZ-interacting protein isoform a

      See identical proteins and their annotated locations for NP_848708.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform a).
      Source sequence(s)
      AK133961, AK168816, BY230131
      Consensus CDS
      CCDS48426.1
      UniProtKB/Swiss-Prot
      Q3TAD8, Q3TBC2, Q3TGA5, Q3UZA1, Q8R3A0
      Related
      ENSMUSP00000043724.9, ENSMUST00000040357.11
      Conserved Domains (3) summary
      COG5271
      Location:200 → 376
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      pfam05177
      Location:231 → 315
      RCSD; RCSD region
      pfam15255
      Location:90 → 171
      CAP-ZIP_m; WASH complex subunit CAP-Z interacting, central region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      165476503..165537632 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006496784.2 → XP_006496847.1  capZ-interacting protein isoform X4

      Conserved Domains (3) summary
      COG5271
      Location:185 → 361
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      pfam05177
      Location:216 → 300
      RCSD; RCSD region
      pfam15255
      Location:66 → 151
      CAP-ZIP_m; WASH complex subunit CAP-Z interacting, central region

    2. XM_006496781.2 → XP_006496844.1  capZ-interacting protein isoform X1

      Conserved Domains (3) summary
      COG5271
      Location:215 → 391
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      pfam05177
      Location:246 → 330
      RCSD; RCSD region
      pfam15255
      Location:96 → 181
      CAP-ZIP_m; WASH complex subunit CAP-Z interacting, central region

    3. XM_006496783.3 → XP_006496846.1  capZ-interacting protein isoform X3

      See identical proteins and their annotated locations for XP_006496846.1

      UniProtKB/Swiss-Prot
      Q3TAD8, Q3TBC2, Q3TGA5, Q3UZA1, Q8R3A0
      Conserved Domains (3) summary
      COG5271
      Location:200 → 376
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      pfam05177
      Location:231 → 315
      RCSD; RCSD region
      pfam15255
      Location:90 → 171
      CAP-ZIP_m; WASH complex subunit CAP-Z interacting, central region

    4. XM_011238794.2 → XP_011237096.1  capZ-interacting protein isoform X2

      See identical proteins and their annotated locations for XP_011237096.1

      Conserved Domains (3) summary
      COG5271
      Location:211 → 387
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      pfam05177
      Location:242 → 326
      RCSD; RCSD region
      pfam15255
      Location:92 → 177
      CAP-ZIP_m; WASH complex subunit CAP-Z interacting, central region
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UZA1.1 GenPept UniProtKB/Swiss-Prot:Q3UZA1

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