Rcn2 reticulocalbin 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rcn2provided by MGI
Official Full Name: reticulocalbin 2provided by MGI
Primary source: MGI:MGI:1349765
See related: Ensembl:ENSMUSG00000032320 AllianceGenome:MGI:1349765
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tcbp49
Summary: Predicted to enable calcium ion binding activity. Predicted to be located in nucleolus. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including axial skeleton; brain ventricular layer; cranium; extraembryonic endoderm; and thyroid cartilage. Orthologous to human RCN2 (reticulocalbin 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 45.9), limb E14.5 (RPKM 44.7) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 B; 9 30.13 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (55949129..55966367)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (56041845..56059083)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Excessive mechanical loading promotes osteoarthritis development by upregulating Rcn2.
Title: Excessive mechanical loading promotes osteoarthritis development by upregulating Rcn2.
RCN2 promotes Nasopharyngeal carcinoma progression by curbing Calcium flow and Mitochondrial apoptosis.
Title: RCN2 promotes Nasopharyngeal carcinoma progression by curbing Calcium flow and Mitochondrial apoptosis.
Reticulocalbin 2 as a Potential Biomarker and Therapeutic Target for Atherosclerosis.
Title: Reticulocalbin 2 as a Potential Biomarker and Therapeutic Target for Atherosclerosis.
Rcn2 regulates blood pressure and contributes to hypertension through actions on endothelial NO synthase.
Title: Loss of reticulocalbin 2 lowers blood pressure and restrains ANG II-induced hypertension in vivo.
Ath29 is confirmed to be a major atherosclerosis susceptibility locus affecting both early and advanced lesion formation in mice, and Rcn2 is identified as a novel regulator of cytokine expression.
Title: Characterization of Ath29, a major mouse atherosclerosis susceptibility locus, and identification of Rcn2 as a novel regulator of cytokine expression.
RCAN2 was highly expressed in scattered neurons, in both the nucleus and the cytoplasm. RCAN2 is the only member of the RCAN family that was detected in glial cells.
Title: Differential expression of members of the RCAN family of calcineurin regulators suggests selective functions for these proteins in the brain.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH124755 (e-PCR)
- UniSTS:161577

RH136604 (e-PCR)
- UniSTS:210584

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum lumen	IEA Inferred from Electronic Annotation more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: reticulocalbin-2

Names: taipoxin-associated calcium binding protein 49

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001278274.1 → NP_001265203.1 reticulocalbin-2 isoform 2 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate 3' structure which results in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AC158999, AK077734

UniProtKB/TrEMBL

Q8BP39

Related

ENSMUSP00000120953.2, ENSMUST00000147842.2

Conserved Domains (2) summary

cd15899
Location:32 → 61

EFh_CREC; EF-hand motif [structural motif]

cl25354
Location:32 → 87

EFh_CREC; EF-hand, calcium binding motif, found in CREC-EF hand family
NM_011992.2 → NP_036122.2 reticulocalbin-2 isoform 1 precursor

See identical proteins and their annotated locations for NP_036122.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC158999, AK077486, BB316373, BB638743

Consensus CDS

CCDS23206.1

UniProtKB/Swiss-Prot

A2RT07, O70341, Q8BP92

UniProtKB/TrEMBL

Q3TE95

Related

ENSMUSP00000109915.3, ENSMUST00000114276.3

Conserved Domains (3) summary

cd00051
Location:68 → 124

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

pfam13499
Location:194 → 259

EF-hand_7; EF-hand domain pair

cl08302
Location:240 → 293

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...