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    Cdc25a cell division cycle 25A [ Mus musculus (house mouse) ]

    Gene ID: 12530, updated on 3-Dec-2024

    Summary

    Official Symbol
    Cdc25aprovided by MGI
    Official Full Name
    cell division cycle 25Aprovided by MGI
    Primary source
    MGI:MGI:103198
    See related
    Ensembl:ENSMUSG00000032477 AllianceGenome:MGI:103198
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D9Ertd393e
    Summary
    Predicted to enable protein kinase binding activity; protein tyrosine phosphatase activity; and protein-folding chaperone binding activity. Predicted to be involved in several processes, including mitotic cell cycle phase transition; positive regulation of cell cycle G2/M phase transition; and positive regulation of cholangiocyte proliferation. Located in cytoplasm and nucleus. Is expressed in several structures, including adrenal gland; central nervous system; early embryo; gonad; and gut. Human ortholog(s) of this gene implicated in autosomal recessive polycystic kidney disease; cervical cancer; prostate cancer; and urinary bladder cancer. Orthologous to human CDC25A (cell division cycle 25A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 11.3), testis adult (RPKM 10.4) and 27 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Cdc25a in Genome Data Viewer
    Location:
    9 F2; 9 59.81 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (109704545..109722963)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (109875518..109893895)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9775 Neighboring gene STARR-seq mESC enhancer starr_25239 Neighboring gene cathelicidin antimicrobial peptide Neighboring gene STARR-positive B cell enhancer ABC_E31 Neighboring gene predicted gene, 39427 Neighboring gene microRNA 7089 Neighboring gene STARR-seq mESC enhancer starr_25247 Neighboring gene STARR-seq mESC enhancer starr_25250 Neighboring gene STARR-positive B cell enhancer ABC_E9336 Neighboring gene predicted gene 4644 Neighboring gene microtubule-associated protein 4 Neighboring gene 60S ribosomal protein L7 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables histone H2AXY142 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables non-membrane spanning protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphoprotein phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphoprotein phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein tyrosine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein tyrosine phosphatase activity, metal-dependent IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein-folding chaperone binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein-folding chaperone binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in G2/M transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in G2/M transition of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in G2/M transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to UV IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to UV ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of G2/M transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of G2/M transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of G2/M transition of mitotic cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of G2/MI transition of meiotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of cholangiocyte proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to radiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to radiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    M-phase inducer phosphatase 1
    Names
    dual specificity phosphatase Cdc25A
    NP_001397314.1
    NP_001397315.1
    NP_001397316.1
    NP_001397317.1
    NP_001397318.1
    NP_031684.3
    XP_006511993.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001410385.1NP_001397314.1  M-phase inducer phosphatase 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      CT573087
      UniProtKB/TrEMBL
      Q80VD9
    2. NM_001410386.1NP_001397315.1  M-phase inducer phosphatase 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      CT573087
      UniProtKB/TrEMBL
      Q80VD9
    3. NM_001410387.1NP_001397316.1  M-phase inducer phosphatase 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      CT573087
      UniProtKB/TrEMBL
      Q80VD9
    4. NM_001410388.1NP_001397317.1  M-phase inducer phosphatase 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      CT573087
    5. NM_001410389.1NP_001397318.1  M-phase inducer phosphatase 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      CT573087
    6. NM_007658.4NP_031684.3  M-phase inducer phosphatase 1 isoform 1

      See identical proteins and their annotated locations for NP_031684.3

      Status: VALIDATED

      Source sequence(s)
      CT573087
      Consensus CDS
      CCDS23559.1
      UniProtKB/Swiss-Prot
      E9PVD0, P48964
      UniProtKB/TrEMBL
      Q80VD9
      Related
      ENSMUSP00000091882.4, ENSMUST00000094324.8
      Conserved Domains (2) summary
      cd01530
      Location:347464
      Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
      pfam06617
      Location:85318
      M-inducer_phosp; M-phase inducer phosphatase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      109704545..109722963
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006511930.5XP_006511993.1  M-phase inducer phosphatase 1 isoform X2

      UniProtKB/TrEMBL
      Q80VD9
      Conserved Domains (2) summary
      cd01530
      Location:354471
      Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
      pfam06617
      Location:85325
      M-inducer_phosp; M-phase inducer phosphatase