Gins3 GINS complex subunit 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gins3provided by MGI
Official Full Name: GINS complex subunit 3provided by MGI
Primary source: MGI:MGI:1926083
See related: Ensembl:ENSMUSG00000031669 AllianceGenome:MGI:1926083
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Psf3; 2700085M18Rik
Summary: Predicted to be involved in DNA unwinding involved in DNA replication and mitotic DNA replication initiation. Predicted to be located in nucleoplasm. Predicted to be part of CMG complex and GINS complex. Is expressed in cerebral cortex ventricular layer and cortical plate. Orthologous to human GINS3 (GINS complex subunit 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in CNS E11.5 (RPKM 5.4), liver E14 (RPKM 3.9) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 D1; 8 47.12 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (96360187..96371687)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (95633559..95645059)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hypomorphic GINS3 variants alter DNA replication and cause Meier-Gorlin syndrome.
Title: Hypomorphic GINS3 variants alter DNA replication and cause Meier-Gorlin syndrome.
expression of mammalian GINS is regulated by 17beta-Estradiol-stimulated estrogen receptor alpha, and PSF3 acts as a gene responsive to transcription factor E2F1
Title: A combined computational and experimental study on the structure-regulation relationships of putative mammalian DNA replication initiator GINS.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI616142 (e-PCR)
- UniSTS:179796

NoName (e-PCR)
- UniSTS:235973

BE103022 (e-PCR)
- UniSTS:244733

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA replication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in DNA unwinding involved in DNA replication	ISO Inferred from Sequence Orthology more info
involved_in DNA unwinding involved in DNA replication	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within cellular senescence	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryo development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic DNA replication initiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of CMG complex	ISO Inferred from Sequence Orthology more info
part_of CMG complex	ISS Inferred from Sequence or Structural Similarity more info
part_of GINS complex	IBA Inferred from Biological aspect of Ancestor more info
part_of GINS complex	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: DNA replication complex GINS protein PSF3

Names: GINS complex subunit 3 (Psf3 homolog)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_030198.3 → NP_084474.1 DNA replication complex GINS protein PSF3

See identical proteins and their annotated locations for NP_084474.1

Status: PROVISIONAL

Source sequence(s)

AC113951

Consensus CDS

CCDS22564.1

UniProtKB/Swiss-Prot

Q9CY94

Related

ENSMUSP00000034094.9, ENSMUST00000034094.11

Conserved Domains (1) summary

cd11713
Location:83 → 192

GINS_A_psf3; Alpha-helical domain of GINS complex protein Psf3 (partner of Sld5 3)