Rps26 ribosomal protein S26 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rps26provided by MGI
Official Full Name: ribosomal protein S26provided by MGI
Primary source: MGI:MGI:1351628
See related: Ensembl:ENSMUSG00000025362 AllianceGenome:MGI:1351628
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: A structural constituent of ribosome. Predicted to be involved in cytoplasmic translation and negative regulation of RNA splicing. Part of cytosolic small ribosomal subunit. Is active in synapse. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 10. Orthologous to human RPS26 (ribosomal protein S26). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in liver E14.5 (RPKM 610.3), liver E14 (RPKM 580.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 D3; 10 77.11 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (128460398..128462375, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (128624529..128626506, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Specific knockout of Rps26 in mouse oocytes resulted in retarded follicle development from pre-antral follicles to antral follicles, while the chromatin configurations of the oocytes were arrested at the transition from the non-surrounded nucleolus (NSN) to surrounded nucleolus (SN)-type
Title: Loss of oocyte Rps26 in mice arrests oocyte growth and causes premature ovarian failure.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA binding	ISO Inferred from Sequence Orthology more info
enables structural constituent of ribosome	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of ribosome	IDA Inferred from Direct Assay more info	PubMed
enables structural constituent of ribosome	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cytoplasmic translation	ISO Inferred from Sequence Orthology more info
involved_in cytoplasmic translation	ISS Inferred from Sequence or Structural Similarity more info
involved_in cytoplasmic translation	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of RNA splicing	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of RNA splicing	ISO Inferred from Sequence Orthology more info
involved_in translation at postsynapse	NAS Non-traceable Author Statement more info	PubMed
involved_in translation at presynapse	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	NAS Non-traceable Author Statement more info	PubMed
located_in cytoplasmic side of rough endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	TAS Traceable Author Statement more info
part_of cytosolic small ribosomal subunit	IBA Inferred from Biological aspect of Ancestor more info
part_of cytosolic small ribosomal subunit	IDA Inferred from Direct Assay more info	PubMed
part_of cytosolic small ribosomal subunit	ISO Inferred from Sequence Orthology more info
part_of cytosolic small ribosomal subunit	ISS Inferred from Sequence or Structural Similarity more info
part_of cytosolic small ribosomal subunit	NAS Non-traceable Author Statement more info	PubMed
is_active_in postsynapse	NAS Non-traceable Author Statement more info	PubMed
is_active_in presynapse	NAS Non-traceable Author Statement more info	PubMed
located_in ribosome	ISO Inferred from Sequence Orthology more info
located_in ribosome	ISS Inferred from Sequence or Structural Similarity more info
is_active_in ribosome	NAS Non-traceable Author Statement more info	PubMed
is_active_in synapse	EXP Inferred from Experiment more info	PubMed
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: small ribosomal subunit protein eS26

Names: 40S ribosomal protein S26

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.